Staff – Department of Biology - University of Copenhagen

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BIO - English > Staff

Rasmus Hartmann-Petersen

Rasmus Hartmann-Petersen

Associate Professor

Teaching

I teach on the following courses:

Gene technology (lectures, seminars, practicals), Protein Chemistry and Enzymology (lectures, practicals), Protein Science (lectures, seminars).

I supervise students on projects related to:

Protein chemistry, Molecular Biology, Cell Biology & Yeast Genetics.

Fields of interest

Intracellular protein degradation, the 26S proteasome, the ubiquitin system, cellular redox control, protein folding, molecular chaperones.

Current research

Our research activity is primarily centred on intracellular protein degradation via the ubiquitin-proteasome pathway. The ubiquitin-proteasome system (link to Bookshelf) is highly conserved and is the major pathway for intracellular proteolysis in all eukaryotic cells. Accordingly, ubiquitin-dependent protein degradation plays a pivotal role in the turnover of key regulatory proteins involved in a series of cellular processes, including cell cycle control, signal transduction, DNA repair, vesicle transport and protein folding. Expectedly, malfunctions in this cellular system are connected with a variety of diseases such as cancer and viral infections as well as neurodegenerative diseases like Parkinson's disease and Alzheimer's syndrome.

In our studies we utilise human tissue culture cells and the fission yeast Schizosaccharomyces pombe as model organisms. As the ubiquitin-proteasome system is remarkably well conserved we tend to use yeast for answering basic cell biological questions as this allows for swifter molecular biological manipulations without limiting the overall scope of the projects. However, when yeast cannot be utilised we use human cells in tissue culture.
Primarily our approach to gaining insight into the molecular mechanisms of intracellular protein degradation is focused on determining novel protein-protein interactions between components of the system. To this end we utilise a variety of genetic, biochemical and molecular biological techniques including, chemical cross-linking, surface plasmon resonance, co-precipitation of fusion proteins, yeast two-hybrid analyses and cDNA suppressor screens. For reviews which are focused on our research interests please see Madsen et al., 2009 (link to PubMed) and Hartmann-Petersen & Gordon, 2004 (link to PubMed).

For further information, please visit the departments homepage.

Selected publications

  1. Published

    Ubxd1 is a novel co-factor of the human p97 ATPase.

    Madsen, L., Andersen, K. M., Prag, S., Moos, T., Semple, C. A., Seeger, M. & Hartmann-Petersen, R. 2008 In : International Journal of Biochemistry & Cell Biology. 40, 12, p. 2927-42 15 p.

    Research output: Research - peer-reviewJournal article

  2. Published

    Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor.

    Jørgensen, J. P., Lauridsen, A-M., Kristensen, P., Dissing, K., Johnsen, A. H., Hendil, K. B. & Hartmann-Petersen, R. 2006 In : Journal of Molecular Biology. 360, 5, p. 1043-52 9 p.

    Research output: Research - peer-reviewJournal article

  3. Published

    The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes.

    Hartmann-Petersen, R., Wallace, M., Hofmann, K., Koch, G., Johnsen, A. H., Hendil, K. B. & Gordon, C. 2004 In : Current Biology. 14, 9, p. 824-8 4 p.

    Research output: Research - peer-reviewJournal article

  4. Published

    Transferring substrates to the 26S proteasome.

    Hartmann-Petersen, R., Seeger, M. & Gordon, C. 2003 In : TIBS -Trends in Biochemical Sciences. Regular ed.. 28, 1, p. 26-31 5 p.

    Research output: Research - peer-reviewJournal article

Selected activities

  1. Current Protein and Peptide Science (Journal)

    Hartmann-Petersen, R. (Editor)
    4 Mar 2005 → …

    Activity: CommunicationEditor of Research journal

  2. Current Proteomics (Journal)

    Hartmann-Petersen, R. (Editor)
    24 Sep 2007 → …

    Activity: CommunicationEditor of Research journal

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