New publication in Microbiome – Section of Microbiology - University of Copenhagen

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06. januar 2017

New publication in Microbiome

New publication from Section of Microbiology in Microbiome


The developing hypopharyngeal microbiota in early life

Microbiome (2016) 4:70

Martin Steen Mortensen, Asker Daniel Brejnrod, Michael Roggenbuck, Waleed Abu Al-Soud, Christina Balle, Karen Angeliki Krogfelt, Jakob Stokholm, Jonathan Thorsen, Johannes Waage, Morten Arendt Rasmussen, Hans Bisgaard and Søren Johannes Sørensen

In this stydy we found that healthy infant airways are colonized by a core microbiota, which contains the majority of the hypopharyngeal microbiota. Our findings demonstrate that there is an overall time-dependent development of the hypopharyngeal microbiota, i.e., the decrease of Staphylococcus and increase of genera normally present in the airways, e.g., Streptococcus, Moraxella, and Haemophilus, leading to the formation of a microbiota community which can be separated into specific pneumotypes. Furthermore, we found that having siblings had the most significant impact on which pneumotype an infant would present, as it was seen that infants with siblings were less likely to harbor a hypopharyngeal microbiota dominated by Staphylococcus.

Our findings indicate that formation and development patterns of the hypopharyngeal microbiota share similarities with gut microbiota. We report that the very early colonization of the hypopharynx is of important for hypopharyngeal microbiota development. Furthermore, as others have shown that airway microbiota composition is related to development of asthmatic disease, indicating that the very early microbiota might influence the risk of asthma later in life.

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