A transomic cohort as a reference point for promoting a healthy human gut microbiome
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- A transomic cohort as a reference point for promoting a healthy human gut microbiome
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More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 100039 |
| Tidsskrift | Medicine in Microecology |
| Vol/bind | 8 |
| Antal sider | 10 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
This study was funded by the Guangdong Key Areas R&D Projects, China (No. 2019B020229003). The authors are very grateful to colleagues at BGI-Shenzhen and China National Genebank (CNGB), Shenzhen, for sample collection, DNA extraction, library construction, sequencing, and discussions. We thank Dr. Qiang Sun (University of Toronto), our colleagues Chen Chen and Yanmei Ju, Jinghua Wu, and Zhe Zhang for their helpful comments.
Funding Information:
This study was funded by the Guangdong Key Areas R&D Projects , China (No. 2019B020229003 ). The authors are very grateful to colleagues at BGI-Shenzhen and China National Genebank (CNGB), Shenzhen, for sample collection, DNA extraction, library construction, sequencing, and discussions. We thank Dr. Qiang Sun (University of Toronto), our colleagues Chen Chen and Yanmei Ju, Jinghua Wu, and Zhe Zhang for their helpful comments.
Publisher Copyright:
© 2021
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