Cervicovaginal microbiome dynamics after taking oral probiotics

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

The vaginal microbiota is less complex than the gut microbiota, and the colonization of Lactobacillus in the female vagina is considered to be critical for reproductive health. Oral probiotics have been suggested as promising means to modulate vaginal homeostasis in the general population. In this study, 60 Chinese women were followed for over a year before, during, and after treatment with the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support a colonization route of the probiotics from the oral cavity to the intestinal tract and then to the vagina. Our analyses enable the classification of the cervicovaginal microbiome into a stable state and a state of dysbiosis. The microbiome in the stable group steadily maintained a relatively high abundance of Lactobacilli over 1 year, which was not affected by probiotic intake, whereas in the dysbiosis group, the microbiota was more diverse and changed markedly over time. Data from a subset of the dysbiosis group suggests this subgroup possibly benefited from supplementation with the probiotics, indicating that probiotics supplementation can be prescribed for women in a subclinical microbiome setting of dysbiosis, providing opportunities for targeted and personalized microbiome reconstitution.

OriginalsprogEngelsk
TidsskriftJournal of Genetics and Genomics
Vol/bind48
Udgave nummer8
Sider (fra-til)716-726
Antal sider11
ISSN1673-8527
DOI
StatusUdgivet - 2021

Bibliografisk note

Funding Information:
We are very grateful to colleagues at BGI-Shenzhen for sample collection, and discussions, and China National Genebank (CNGB) Shenzhen for DNA extraction, library construction, and sequencing.

Publisher Copyright:
© 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China

ID: 279133771