De Novo Pathway-Based Classification of Breast Cancer Subtypes
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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De Novo Pathway-Based Classification of Breast Cancer Subtypes. / List, Markus; Alcaraz, Nicolas; Batra, Richa.
Protein-Protein Interaction Networks: Methods and Protocols. red. / Stefan Canzar; Francisca Rojas Ringeling. Humana Press, 2020. s. 201-213 (Methods in Molecular Biology, Bind 2074).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - De Novo Pathway-Based Classification of Breast Cancer Subtypes
AU - List, Markus
AU - Alcaraz, Nicolas
AU - Batra, Richa
PY - 2020
Y1 - 2020
N2 - Breast cancer is a heterogeneous disease for which various clinically relevant subtypes have been reported. These subtypes are characterized by molecular differences which direct treatment selection. The state of the art for breast cancer subtyping utilizes histochemistry or gene expression to measure a few selected markers. However, classification based on molecular pathways (rather than individual markers) is a more robust way to classify breast cancer samples into known subtypes. Here, we present PathClass, a web application that allows its users to predict breast cancer subtypes using various traditional as well as advanced methods. This includes methods based on classical gene expression panels as well as de novo pathway-based predictors. Users can predict labels for datasets in the Gene Expression Omnibus or upload their own expression profiling data. Availability: https://pathclass.compbio.sdu.dk/.
AB - Breast cancer is a heterogeneous disease for which various clinically relevant subtypes have been reported. These subtypes are characterized by molecular differences which direct treatment selection. The state of the art for breast cancer subtyping utilizes histochemistry or gene expression to measure a few selected markers. However, classification based on molecular pathways (rather than individual markers) is a more robust way to classify breast cancer samples into known subtypes. Here, we present PathClass, a web application that allows its users to predict breast cancer subtypes using various traditional as well as advanced methods. This includes methods based on classical gene expression panels as well as de novo pathway-based predictors. Users can predict labels for datasets in the Gene Expression Omnibus or upload their own expression profiling data. Availability: https://pathclass.compbio.sdu.dk/.
KW - Breast cancer
KW - Classification
KW - De novo pathways
KW - Disease subtyping
U2 - 10.1007/978-1-4939-9873-9_15
DO - 10.1007/978-1-4939-9873-9_15
M3 - Book chapter
C2 - 31583640
AN - SCOPUS:85072911207
SN - 978-1-4939-9872-2
T3 - Methods in Molecular Biology
SP - 201
EP - 213
BT - Protein-Protein Interaction Networks
A2 - Canzar, Stefan
A2 - Ringeling, Francisca Rojas
PB - Humana Press
ER -
ID: 230742706