Ecological succession in the vaginal microbiota during pregnancy and birth

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Ecological succession in the vaginal microbiota during pregnancy and birth. / Rasmussen, M. A.; Thorsen, J.; Dominguez-Bello, M. G.; Blaser, M. J.; Mortensen, M. S.; Brejnrod, A. D.; Shah, S. A.; Hjelmsø, M. H.; Lehtimäki, J.; Trivedi, U.; Bisgaard, H.; Sørensen, S. J.; Stokholm, J.

I: The ISME Journal, Bind 14, Nr. 9, 2020, s. 2325-2335.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, MA, Thorsen, J, Dominguez-Bello, MG, Blaser, MJ, Mortensen, MS, Brejnrod, AD, Shah, SA, Hjelmsø, MH, Lehtimäki, J, Trivedi, U, Bisgaard, H, Sørensen, SJ & Stokholm, J 2020, 'Ecological succession in the vaginal microbiota during pregnancy and birth', The ISME Journal, bind 14, nr. 9, s. 2325-2335. https://doi.org/10.1038/s41396-020-0686-3

APA

Rasmussen, M. A., Thorsen, J., Dominguez-Bello, M. G., Blaser, M. J., Mortensen, M. S., Brejnrod, A. D., Shah, S. A., Hjelmsø, M. H., Lehtimäki, J., Trivedi, U., Bisgaard, H., Sørensen, S. J., & Stokholm, J. (2020). Ecological succession in the vaginal microbiota during pregnancy and birth. The ISME Journal, 14(9), 2325-2335. https://doi.org/10.1038/s41396-020-0686-3

Vancouver

Rasmussen MA, Thorsen J, Dominguez-Bello MG, Blaser MJ, Mortensen MS, Brejnrod AD o.a. Ecological succession in the vaginal microbiota during pregnancy and birth. The ISME Journal. 2020;14(9):2325-2335. https://doi.org/10.1038/s41396-020-0686-3

Author

Rasmussen, M. A. ; Thorsen, J. ; Dominguez-Bello, M. G. ; Blaser, M. J. ; Mortensen, M. S. ; Brejnrod, A. D. ; Shah, S. A. ; Hjelmsø, M. H. ; Lehtimäki, J. ; Trivedi, U. ; Bisgaard, H. ; Sørensen, S. J. ; Stokholm, J. / Ecological succession in the vaginal microbiota during pregnancy and birth. I: The ISME Journal. 2020 ; Bind 14, Nr. 9. s. 2325-2335.

Bibtex

@article{a0b8063713074afdb5bd027cf0894e50,
title = "Ecological succession in the vaginal microbiota during pregnancy and birth",
abstract = "The mother's vaginal microbiota represents the first microbes to which a child is exposed when delivered vaginally. However, little is known about the composition and development of the vaginal microbiota during pregnancy and birth. Here, we analyzed the vaginal microbiota of 57 women in pregnancy week 24, 36 and at birth after rupture of membranes but before delivery, and further compared the composition with that of the gut and airways of the 1-week-old child. The vaginal community structure had dramatic changes in bacterial diversity and taxonomic distribution, yet carried an individual-specific signature. The relative abundance of most bacterial taxa increased stepwise from week 24 of pregnancy until birth, with a gradual decline of Lactobacillus. Mother-to-child vertical transfer, as suggested by sharing, was modest, with the strongest transfer being for Clostridiales followed by Lactobacillales and Enterobacteriales. In conclusion, late gestation is associated with an increase in maternal vaginal microbiota diversity, and vaginal bacteria at birth only modestly predict the composition of the neonatal microbiota.",
author = "Rasmussen, {M. A.} and J. Thorsen and Dominguez-Bello, {M. G.} and Blaser, {M. J.} and Mortensen, {M. S.} and Brejnrod, {A. D.} and Shah, {S. A.} and Hjelms{\o}, {M. H.} and J. Lehtim{\"a}ki and U. Trivedi and H. Bisgaard and S{\o}rensen, {S. J.} and J. Stokholm",
year = "2020",
doi = "10.1038/s41396-020-0686-3",
language = "English",
volume = "14",
pages = "2325--2335",
journal = "I S M E Journal",
issn = "1751-7362",
publisher = "nature publishing group",
number = "9",

}

RIS

TY - JOUR

T1 - Ecological succession in the vaginal microbiota during pregnancy and birth

AU - Rasmussen, M. A.

AU - Thorsen, J.

AU - Dominguez-Bello, M. G.

AU - Blaser, M. J.

AU - Mortensen, M. S.

AU - Brejnrod, A. D.

AU - Shah, S. A.

AU - Hjelmsø, M. H.

AU - Lehtimäki, J.

AU - Trivedi, U.

AU - Bisgaard, H.

AU - Sørensen, S. J.

AU - Stokholm, J.

PY - 2020

Y1 - 2020

N2 - The mother's vaginal microbiota represents the first microbes to which a child is exposed when delivered vaginally. However, little is known about the composition and development of the vaginal microbiota during pregnancy and birth. Here, we analyzed the vaginal microbiota of 57 women in pregnancy week 24, 36 and at birth after rupture of membranes but before delivery, and further compared the composition with that of the gut and airways of the 1-week-old child. The vaginal community structure had dramatic changes in bacterial diversity and taxonomic distribution, yet carried an individual-specific signature. The relative abundance of most bacterial taxa increased stepwise from week 24 of pregnancy until birth, with a gradual decline of Lactobacillus. Mother-to-child vertical transfer, as suggested by sharing, was modest, with the strongest transfer being for Clostridiales followed by Lactobacillales and Enterobacteriales. In conclusion, late gestation is associated with an increase in maternal vaginal microbiota diversity, and vaginal bacteria at birth only modestly predict the composition of the neonatal microbiota.

AB - The mother's vaginal microbiota represents the first microbes to which a child is exposed when delivered vaginally. However, little is known about the composition and development of the vaginal microbiota during pregnancy and birth. Here, we analyzed the vaginal microbiota of 57 women in pregnancy week 24, 36 and at birth after rupture of membranes but before delivery, and further compared the composition with that of the gut and airways of the 1-week-old child. The vaginal community structure had dramatic changes in bacterial diversity and taxonomic distribution, yet carried an individual-specific signature. The relative abundance of most bacterial taxa increased stepwise from week 24 of pregnancy until birth, with a gradual decline of Lactobacillus. Mother-to-child vertical transfer, as suggested by sharing, was modest, with the strongest transfer being for Clostridiales followed by Lactobacillales and Enterobacteriales. In conclusion, late gestation is associated with an increase in maternal vaginal microbiota diversity, and vaginal bacteria at birth only modestly predict the composition of the neonatal microbiota.

U2 - 10.1038/s41396-020-0686-3

DO - 10.1038/s41396-020-0686-3

M3 - Journal article

C2 - 32488167

VL - 14

SP - 2325

EP - 2335

JO - I S M E Journal

JF - I S M E Journal

SN - 1751-7362

IS - 9

ER -

ID: 242994139