HIV and metabolic syndrome in an Ethiopian population

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HIV and metabolic syndrome in an Ethiopian population. / Møller, Sanne Pagh; Amare, Hiwot; Christensen, Dirk Lund; Yilma, Daniel; Abdissa, Alemseged; Friis, Henrik; Faurholt-Jepsen, Daniel; Olsen, Mette Frahm.

I: Annals of Human Biology, Bind 47, Nr. 5, 20.07.2020, s. 457-464.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Møller, SP, Amare, H, Christensen, DL, Yilma, D, Abdissa, A, Friis, H, Faurholt-Jepsen, D & Olsen, MF 2020, 'HIV and metabolic syndrome in an Ethiopian population', Annals of Human Biology, bind 47, nr. 5, s. 457-464. https://doi.org/10.1080/03014460.2020.1781929

APA

Møller, S. P., Amare, H., Christensen, D. L., Yilma, D., Abdissa, A., Friis, H., Faurholt-Jepsen, D., & Olsen, M. F. (2020). HIV and metabolic syndrome in an Ethiopian population. Annals of Human Biology, 47(5), 457-464. https://doi.org/10.1080/03014460.2020.1781929

Vancouver

Møller SP, Amare H, Christensen DL, Yilma D, Abdissa A, Friis H o.a. HIV and metabolic syndrome in an Ethiopian population. Annals of Human Biology. 2020 jul. 20;47(5): 457-464. https://doi.org/10.1080/03014460.2020.1781929

Author

Møller, Sanne Pagh ; Amare, Hiwot ; Christensen, Dirk Lund ; Yilma, Daniel ; Abdissa, Alemseged ; Friis, Henrik ; Faurholt-Jepsen, Daniel ; Olsen, Mette Frahm. / HIV and metabolic syndrome in an Ethiopian population. I: Annals of Human Biology. 2020 ; Bind 47, Nr. 5. s. 457-464.

Bibtex

@article{5afd87975a0147d1ad1daa306457c93f,
title = "HIV and metabolic syndrome in an Ethiopian population",
abstract = "Background: The global prevalence of metabolic syndrome (MS) is increasing due to lifestyle changes. Studies have found that MS is associated with human immunodeficiency virus (HIV) and antiretroviral treatment (ART), but controversies still exist on associations between HIV and MS.Aims: To assess associations between HIV and MS among ART-na{\"i}ve HIV positive individuals compared to HIV negative individuals.Subjects and methods: A cross-sectional study among ART-na{\"i}ve HIV positive and HIV negative individuals recruited from HIV treatment and testing facilities in Ethiopia. Information was collected on components of MS: waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure and fasting plasma glucose (FPG). Data were analysed using logistic and linear regression stratified by sex and adjusted for age, wealth and education.Results: Data from 329 HIV positive and 100 HIV negative individuals were included. HIV positive status was associated with higher odds of MS in women (OR: 3.56, 95%CI: 1.25; 10.15) (n = 292), but not in men (OR: 0.98, 95%CI: 0.22; 4.30) (n = 137), interaction: p= .11. Associations between HIV and components of MS were strongest for HDL-C among women and for FPG among men. The most prevalent components of MS in HIV positive individuals were elevated triglycerides, reduced HDL-C and elevated FPG.Conclusions: HIV was associated with MS among ART-na{\"i}ve women, suggesting that MS should be evaluated before initiating ART and monitored during treatment to identify those at risk of developing diabetes and cardiovascular disease (CVD).",
keywords = "Faculty of Science, HIV, ART-na{\"i}ve, Metabolic syndrome, Sub-Saharan Africa, Ethiopia",
author = "M{\o}ller, {Sanne Pagh} and Hiwot Amare and Christensen, {Dirk Lund} and Daniel Yilma and Alemseged Abdissa and Henrik Friis and Daniel Faurholt-Jepsen and Olsen, {Mette Frahm}",
note = "CURIS 2020 NEXS 215",
year = "2020",
month = jul,
day = "20",
doi = "10.1080/03014460.2020.1781929",
language = "English",
volume = "47",
pages = " 457--464",
journal = "Annals of Human Biology",
issn = "0301-4460",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - HIV and metabolic syndrome in an Ethiopian population

AU - Møller, Sanne Pagh

AU - Amare, Hiwot

AU - Christensen, Dirk Lund

AU - Yilma, Daniel

AU - Abdissa, Alemseged

AU - Friis, Henrik

AU - Faurholt-Jepsen, Daniel

AU - Olsen, Mette Frahm

N1 - CURIS 2020 NEXS 215

PY - 2020/7/20

Y1 - 2020/7/20

N2 - Background: The global prevalence of metabolic syndrome (MS) is increasing due to lifestyle changes. Studies have found that MS is associated with human immunodeficiency virus (HIV) and antiretroviral treatment (ART), but controversies still exist on associations between HIV and MS.Aims: To assess associations between HIV and MS among ART-naïve HIV positive individuals compared to HIV negative individuals.Subjects and methods: A cross-sectional study among ART-naïve HIV positive and HIV negative individuals recruited from HIV treatment and testing facilities in Ethiopia. Information was collected on components of MS: waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure and fasting plasma glucose (FPG). Data were analysed using logistic and linear regression stratified by sex and adjusted for age, wealth and education.Results: Data from 329 HIV positive and 100 HIV negative individuals were included. HIV positive status was associated with higher odds of MS in women (OR: 3.56, 95%CI: 1.25; 10.15) (n = 292), but not in men (OR: 0.98, 95%CI: 0.22; 4.30) (n = 137), interaction: p= .11. Associations between HIV and components of MS were strongest for HDL-C among women and for FPG among men. The most prevalent components of MS in HIV positive individuals were elevated triglycerides, reduced HDL-C and elevated FPG.Conclusions: HIV was associated with MS among ART-naïve women, suggesting that MS should be evaluated before initiating ART and monitored during treatment to identify those at risk of developing diabetes and cardiovascular disease (CVD).

AB - Background: The global prevalence of metabolic syndrome (MS) is increasing due to lifestyle changes. Studies have found that MS is associated with human immunodeficiency virus (HIV) and antiretroviral treatment (ART), but controversies still exist on associations between HIV and MS.Aims: To assess associations between HIV and MS among ART-naïve HIV positive individuals compared to HIV negative individuals.Subjects and methods: A cross-sectional study among ART-naïve HIV positive and HIV negative individuals recruited from HIV treatment and testing facilities in Ethiopia. Information was collected on components of MS: waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure and fasting plasma glucose (FPG). Data were analysed using logistic and linear regression stratified by sex and adjusted for age, wealth and education.Results: Data from 329 HIV positive and 100 HIV negative individuals were included. HIV positive status was associated with higher odds of MS in women (OR: 3.56, 95%CI: 1.25; 10.15) (n = 292), but not in men (OR: 0.98, 95%CI: 0.22; 4.30) (n = 137), interaction: p= .11. Associations between HIV and components of MS were strongest for HDL-C among women and for FPG among men. The most prevalent components of MS in HIV positive individuals were elevated triglycerides, reduced HDL-C and elevated FPG.Conclusions: HIV was associated with MS among ART-naïve women, suggesting that MS should be evaluated before initiating ART and monitored during treatment to identify those at risk of developing diabetes and cardiovascular disease (CVD).

KW - Faculty of Science

KW - HIV

KW - ART-naïve

KW - Metabolic syndrome

KW - Sub-Saharan Africa

KW - Ethiopia

U2 - 10.1080/03014460.2020.1781929

DO - 10.1080/03014460.2020.1781929

M3 - Journal article

C2 - 32683894

VL - 47

SP - 457

EP - 464

JO - Annals of Human Biology

JF - Annals of Human Biology

SN - 0301-4460

IS - 5

ER -

ID: 245228914