Ion Channels Involved in Cell Volume Regulation: Effects on Migration, Proliferation, and Programmed Cell Death in Non Adherent EAT Cells and Adherent ELA Cells

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

  • Else Kay Hoffmann
This mini review outlines studies of cell volume regulation in two closely related mammalian cell lines: nonadherent Ehrlich ascites tumour cells (EATC) and adherent Ehrlich Lettre ascites (ELA) cells. Focus is on the regulatory volume decrease (RVD) that occurs after cell swelling, the volume regulatory ion channels involved, and the mechanisms (cellular signalling pathways) that regulate these channels. Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation, and programmed cell death.
OriginalsprogEngelsk
TidsskriftCellular Physiology and Biochemistry
Vol/bind28
Udgave nummer6
Sider (fra-til)1061-78
Antal sider18
ISSN1015-8987
DOI
StatusUdgivet - 2011

ID: 36069906