The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster

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The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. / Cannell, Elizabeth; Dornan, Anthony J.; Halberg, Kenneth Agerlin; Terhzaz, Selim; Dow, Julian A.T.; Davies, Shireen-A.

I: Peptides, Bind 80, 2016, s. 96-107.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Cannell, E, Dornan, AJ, Halberg, KA, Terhzaz, S, Dow, JAT & Davies, S-A 2016, 'The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster', Peptides, bind 80, s. 96-107. https://doi.org/10.1016/j.peptides.2016.02.004

APA

Cannell, E., Dornan, A. J., Halberg, K. A., Terhzaz, S., Dow, J. A. T., & Davies, S-A. (2016). The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, 96-107. https://doi.org/10.1016/j.peptides.2016.02.004

Vancouver

Cannell E, Dornan AJ, Halberg KA, Terhzaz S, Dow JAT, Davies S-A. The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides. 2016;80:96-107. https://doi.org/10.1016/j.peptides.2016.02.004

Author

Cannell, Elizabeth ; Dornan, Anthony J. ; Halberg, Kenneth Agerlin ; Terhzaz, Selim ; Dow, Julian A.T. ; Davies, Shireen-A. / The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. I: Peptides. 2016 ; Bind 80. s. 96-107.

Bibtex

@article{e1f07ce77bad4448864d4af7cc8d81a3,
title = "The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster",
abstract = "Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, and are under neuroendocrine control by multiple neuropeptides secreted by identified neurons. Here, we demonstrate roles for CRF-like diuretic hormone 44 (DH44) and Drosophila melanogaster kinin (Drome-kinin, DK) in desiccation and starvation tolerance. Gene expression and labelled DH44 ligand binding data, as well as highly selective knockdowns and/or neuronal ablations of DH44 in neurons of the pars intercerebralis and DH44 receptor (DH44-R2) in Malpighian tubule principal cells, indicate that suppression of DH44 signalling improves desiccation tolerance of the intact fly. Drome-kinin receptor, encoded by the leucokinin receptor gene, LKR, is expressed in DH44 neurons as well as in stellate cells of the Malpighian tubules. LKR knockdown in DH44-expressing neurons reduces Malpighian tubule-specific LKR, suggesting interactions between DH44 and LK signalling pathways. Finally, although a role for DK in desiccation tolerance was not defined, we demonstrate a novel role for Malpighian tubule cell-specific LKR in starvation tolerance. Starvation increases gene expression of epithelial LKR. Also, Malpighian tubule stellate cell-specific knockdown of LKR significantly reduced starvation tolerance, demonstrating a role for neuropeptide signalling during starvation stress.",
keywords = "Faculty of Science, Neuropeptides, Drosohila, DH44, Kinin",
author = "Elizabeth Cannell and Dornan, {Anthony J.} and Halberg, {Kenneth Agerlin} and Selim Terhzaz and Dow, {Julian A.T.} and Shireen-A Davies",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
doi = "10.1016/j.peptides.2016.02.004",
language = "English",
volume = "80",
pages = "96--107",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster

AU - Cannell, Elizabeth

AU - Dornan, Anthony J.

AU - Halberg, Kenneth Agerlin

AU - Terhzaz, Selim

AU - Dow, Julian A.T.

AU - Davies, Shireen-A

N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, and are under neuroendocrine control by multiple neuropeptides secreted by identified neurons. Here, we demonstrate roles for CRF-like diuretic hormone 44 (DH44) and Drosophila melanogaster kinin (Drome-kinin, DK) in desiccation and starvation tolerance. Gene expression and labelled DH44 ligand binding data, as well as highly selective knockdowns and/or neuronal ablations of DH44 in neurons of the pars intercerebralis and DH44 receptor (DH44-R2) in Malpighian tubule principal cells, indicate that suppression of DH44 signalling improves desiccation tolerance of the intact fly. Drome-kinin receptor, encoded by the leucokinin receptor gene, LKR, is expressed in DH44 neurons as well as in stellate cells of the Malpighian tubules. LKR knockdown in DH44-expressing neurons reduces Malpighian tubule-specific LKR, suggesting interactions between DH44 and LK signalling pathways. Finally, although a role for DK in desiccation tolerance was not defined, we demonstrate a novel role for Malpighian tubule cell-specific LKR in starvation tolerance. Starvation increases gene expression of epithelial LKR. Also, Malpighian tubule stellate cell-specific knockdown of LKR significantly reduced starvation tolerance, demonstrating a role for neuropeptide signalling during starvation stress.

AB - Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, and are under neuroendocrine control by multiple neuropeptides secreted by identified neurons. Here, we demonstrate roles for CRF-like diuretic hormone 44 (DH44) and Drosophila melanogaster kinin (Drome-kinin, DK) in desiccation and starvation tolerance. Gene expression and labelled DH44 ligand binding data, as well as highly selective knockdowns and/or neuronal ablations of DH44 in neurons of the pars intercerebralis and DH44 receptor (DH44-R2) in Malpighian tubule principal cells, indicate that suppression of DH44 signalling improves desiccation tolerance of the intact fly. Drome-kinin receptor, encoded by the leucokinin receptor gene, LKR, is expressed in DH44 neurons as well as in stellate cells of the Malpighian tubules. LKR knockdown in DH44-expressing neurons reduces Malpighian tubule-specific LKR, suggesting interactions between DH44 and LK signalling pathways. Finally, although a role for DK in desiccation tolerance was not defined, we demonstrate a novel role for Malpighian tubule cell-specific LKR in starvation tolerance. Starvation increases gene expression of epithelial LKR. Also, Malpighian tubule stellate cell-specific knockdown of LKR significantly reduced starvation tolerance, demonstrating a role for neuropeptide signalling during starvation stress.

KW - Faculty of Science

KW - Neuropeptides

KW - Drosohila

KW - DH44

KW - Kinin

U2 - 10.1016/j.peptides.2016.02.004

DO - 10.1016/j.peptides.2016.02.004

M3 - Journal article

C2 - 26896569

VL - 80

SP - 96

EP - 107

JO - Peptides

JF - Peptides

SN - 0196-9781

ER -

ID: 161009248