Metabolic Regulation Lab – Cell Biology and Physiology

Metabolic Regulation Lab

Welcome to the Metabolic Regulation Lab website! Here, you can find information about our ongoing research, recent publications, present and former lab members, available student projects and how to contact us.

We study adipocytes (fat cells) and adipose tissue. In recent years, our focus has been on the molecular control of differentiation, activation and metabolism of brown adipocytes. Our interest in brown adipose tissue biology derives from the striking ability of brown adipocytes to counteract obesity and insulin resistance in experimental animals and the observation that active brown fat is present in many adult humans. Ongoing projects revolve around metabolic regulation and signal transduction. Our aim is to uncover novel regulatory mechanisms through which brown adipose tissue can be exploited therapeutically.

We use a variety of experimental models such as human and mouse cells, including primary cell cultures, and mice. In addition to cell cultures, we apply e.g. large-scale gene expression profiling, RT-qPCR, immunoblotting, ELISA, enzyme activity and metabolite measurements, real-time cellular respiration (Seahorse XF96 Flux Analyzer), siRNA/shRNA-mediated gene silencing, siRNA screens, compound screens and viral overexpression.

If you are interested in learning more about our research and the projects that we offer, please study our website or contact us for more information.