Biomolecular Sciences – Biologisk Institut - Københavns Universitet

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Section for Biomolecular Sciences

Research in proteins from protein design over structure and dynamics to their roles in cellular regulation and their synthesis and degradation.

MAIN RESEARCH AREAS

1) Structure, folding and dynamics of proteins

  • Intrinsically Disordered Proteins
  • The relationship between dynamics and function of proteins incl. enzymes
  • Methods to integrate NMR and computation
  • Protein structure in biological processes and signalling

2) Protein Biology

  • Protein misfolding
  • Cellular responses to protein misfolding
  • Degradation of misfolded and intrinsically disordered proteins via the ubiquitinproteasome system
  • Proteins in transcriptional networks

3) Protein Design and Enzymology

  • Development of new tools in protein design and redesign
  • Basic properties of proteins such as charge interactions and enzyme specificity
  • Computational models and expression, purification and characterization
  • Smart screening systems

4) Biomolecular Regulation

  • Regulatory and mechanistic aspects of gene expression
  • Dynamic biological systems
  • Molecular-to population scale mathematical modeling and experimental testing
  • RNA molecules as regulators and mediators of protein synthesis

Research facilities and methods include high-field NMR facilities (600, 750 and 800 MHz spectrometers), a broad range of equipment for protein chemistry and biophysical protein characterization, including CD and fluorescence spectroscopy, micro-calorimetry and dynamic light scattering, as well as mammalian cell culture and molecular biology facilities and cell biological techniques employed in a range of model systems incl. mammalian cells, yeast and plants.