Bacteriophage control of microbial biofilms - Vibrio anguillarum in aquaculture settings

Main area:Marine biology
 
Target group:Biology, Biochemistry
 
Educational level:Masters, Bachelor
 
Project description:

Vibrio anguillarum is a marine pathogenic bacterium causing vibriosis, which contributes to significant mortalities in fish and shellfish aquaculture worldwide, with a fatal hemorrhagic septicemia and responsible for severe economic losses in marine aquaculture industry, especially during the larval stage, where the immune system is not fully developed.

V. anguillarum is part of the natural free-living, planktonic microbiota in marine environments. However, the mode of infection for V. anguillarum most likely involves attachment to and colonization of host epithelial cells, followed by penetration of the tissues.

In the current project we investigate to potential of bacteriophages to control V. anguillarum biofilms in various experimental settings in the lab. The work will explore different mechanisms of bacterial protection from bacteriophage attack, including aggregration and quorum sensing communication between bacteria.

 
Methods used:microbiological and molecular biological methodology
 
Keywords:biofilm, pathogens, viruses, microbial interactions, disease
 
Supervisor(s):  Mathias Middelboe
 
Email:mmiddelboe@bio.ku.dk