The aim of our research is to understand RNA based mechanisms involved in the control of cellular processes, in particular those that are related to disease and affects the efficiency of cell based production systems. Moreover, we want to contribute to the further development of RNA based therapies that utilize our knowledge of RNA based mechanisms.

Our Research

Over the last years, our group has contributed to the further development of methods for detection of RNA modifications and for probing RNA structure. Historically, these methods have been restricted to the analysis of one RNA molecule at the time, but by adapting the experiments for modern sequencing technology and developing novel computational tools, we have increased the throughput of such experiments by several orders of magnitude to make transcriptome wide analysis possible. Our methods give us a unique possibility to identify RNA structural and regulatory changes inside cells. 
See our publications.  

Resources

m7G-MaP-seq: our method for mapping of N7-methyl-guanosine RNA modifications. Publication. Tools.

RNA-seq protocol: Publication. Tools.

RNAprobR: R-package for analysis of Reverse Transcription termination data, including RNA structure probing data. Publication. Tools. R-package.

Staff

Jeppe Vinther, PhD, Associate Professor, Groupleader.
Research topics: All aspects of RNA regulation, including RNA structure, modification and oxidation as well RNA antisense methods for gene regulation.


Anya Sherwood, PhD, Postdoc VintherLab
Research topics: RNA modification and oxidation.


Annaleigh Orth Fehler, MSc, PhD student, VintherLab
Research topics: RNA structure, Bacillus Subtilis gene regulation


Klara Marie Andersen, MSc student, VintherLab
Research topics: HCV, RNA modification


Amal Al-Chaer, Lab Technician, VintherLab