The research projects of the Biomolecular Regulation group address fundamental regulatory and mechanistic aspects of gene expression.  In collaboration with biophysicists at the Niels Bohr Institute, we combine molecular-to-population scale mathematical modeling and experimental testing to obtain an integrated and quantitative understanding of dynamic biological systems.

A common interest among the group members is the role of RNA molecules as regulators and mediators of protein synthesis.  Current projects within this area includes the identification of intramolecular determinants of mRNA half-life, determination of codon-specific translation rates, unraveling of the mechanisms underlying translational fidelity during stress,  coupling between mRNA pseudoknot strengths and programmed frameshifting, and quantitaive comparisons of the impact of different regulatory mechanisms on the dynamic behaivor of gene regulatory networks.

To address these problems we employ a wide range of experimental techniques from the “toothpicks-and-logic” approach of classical microbial genetics to single molecule techniques, proteomics, and nanotechnology.

For students

We offer a range of different phd projects, often in collaboration with international academic coworkers or industrial domestic partners. As a phd student you are accepted into the phd school at the Faculty of Science and become part of the phd program in Protein Science. Please apply directly with the individual principal investigators.

More details

Research in BRG

The research in the Biomolecular Regulation Group focus on interactions in bacterial systems.

More details