The research projects of the Biomolecular Regulation group address fundamental regulatory and mechanistic aspects of gene expression. In collaboration with biophysicists at the Niels Bohr Institute, we combine molecular-to-population scale mathematical modeling and experimental testing to obtain an integrated and quantitative understanding of dynamic biological systems.
A common interest among the group members is the role of RNA molecules as regulators and mediators of protein synthesis. Current projects within this area includes the identification of intramolecular determinants of mRNA half-life, determination of codon-specific translation rates, unraveling of the mechanisms underlying translational fidelity during stress, coupling between mRNA pseudoknot strengths and programmed frameshifting, and quantitaive comparisons of the impact of different regulatory mechanisms on the dynamic behaivor of gene regulatory networks.
To address these problems we employ a wide range of experimental techniques from the “toothpicks-and-logic” approach of classical microbial genetics to single molecule techniques, proteomics, and nanotechnology.
How do bacteria survive?
A collaboration between the Svenningsen lab and scientists from the Niels Bohr Institute just published a beautiful study in PNAS explaining how bacteria survive virus (bacteriophage) infections by using the outermost layer of bacteria as a shield.