Welcome to the Sine Lo Svenningsen Group
Our research interests centers on bacterial gene regulation. The components and interaction partners of gene regulatory networks are being identified at a breakneck pace in genome-wide studies in many model organisms. In the post-genomic era, a central challenge is to understand the processes that govern the dynamics of such networks. We are interested in all aspects of gene regulatory network analysis, from dissecting detailed molecular mechanisms of regulation to determining the logic and dynamic behavior of the network as a whole. In the group, we study either synthetic networks, or existing networks that control behaviors where timing and network dynamics are expected to be particularly critical. This is true, for example, of the networks regulating bacterial cell-cell communication (quorum sensing), bacterial stress responses, or bacteriophage developmental decisions. On most projects, we collaborate with biophysicists to develop theoretical models that help us answer fundamental physiological or mechanistic questions in a quantitative manner.
Our group has close ties to the rest of the Biomolecular regulation group and we are part of the Centre for Bacterial Stress Survival and Persistence, a Centre of Excellence funded by the Danish National Research Foundation and the Novo Nordisk Foundation, which is headed by Professor Kenn Gerdes. The overall aim of the BASP Centre is to understand the survival mechanisms that bacteria employ in response to environmental stresses. We are particularly interested in exploring two aspects of bacterial survival strategies, namely the rapid transcriptional and translational reprogramming that occurs in E. coli in response to starvation, and how phenotypic heterogeneity within a population of stressed cells may influence their survival.
Contact Sine if you are interested in our work – we always welcome applications to join the lab. You can read more about current research projects here.
You are allways wellcome to submit applications for postdoc, PhD or Master projects. If you are interested in joining the group please contact me by mail or phone.
How do bacteria survive?
A collaboration between the Svenningsen lab and scientists from the Niels Bohr Institute just published a beautiful study in PNAS explaining how bacteria survive virus (bacteriophage) infections by using the outermost layer of bacteria as a shield.