Publications from

Total publications from unit:



Amie J. McClellan, Sophie Heiden Laugesen and Lars Ellgaard. (2019) Cellular functions and molecular mechanisms of non-lysine ubiquitination Open Biology 9(9).


Lau D Nielsen, Mads M. Foged, Anastasia Albert, Andreas B. Bertelsen, Cecilie L Søltoft, Samuel D. Robinson, Steen Vang Petersen, Anthony W. Purcell, Baldomero M. Olivera, Raymond S. Norton, Terje Vas (2019) The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework The Journal of Biological Chemistry 294(22):8745-8759.



Lars Ellgaard, Carolyn S. Sevier and Neil J. Bulleid. (2018) How are proteins reduced in the endoplasmic reticulum? Trends in Biochemical Sciences 43(1):32-43.


Helena Safavi-Hemami, Mads Møller Foged and Lars Ellgaard. (2018) Evolutionary Adaptations to Cysteine-rich Peptide Folding Book chapter in False Matthias J. Feige. (eds.) Royal Society of Chemistry, p. 99-128.


Henrik O'Brien, Shingo Kanemura, Masaki Okumura, Robert P. Baskin, Pradip K. Bandyopadhyay, Baldomero M. Olivera, Lars Ellgaard, Kenji Inaba and Helena Safavi-Hemami. (2018) Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins International Journal of Molecular Sciences 19(11).



Lars Ellgaard, Nicholas McCaul, Anna Chatsisvili and Ineke Braakman. (2016) Co- and post-translational protein folding in the ER Traffic (Malden) 17(6):615-638.


Helena Safavi-Hemami, Qing Li, Ronneshia L. Jackson, Albert S. Song, Wouter Krogh Boomsma, Pradip K. Bandyopadhyay, Christian W. Gruber, Anthony W. Purcell, Mark Yandell, Baldomero M. Olivera and Lars  (2016) Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides Proceedings of the National Academy of Sciences of the United States of America 113(12):3227-3232.


Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea Cecilie Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard and Paul J. Lehner. (2016) Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens Nature Communications 7.


Wouter Krogh Boomsma, Sofie Vincents Nielsen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen and Lars Ellgaard. (2016) Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases PeerJ 4.



Helena Safavi-Hemami, Joanna Gajewiak, Santhosh Karanth, Samuel D. Robinson, Beatrix Ueberheide, Adam D. Douglass, Amnon Schlegel, Julita S. Imperial, Maren Watkins, Pradip K. Bandyopadhyay, Mark Yand (2015) Specialized insulin is used for chemical warfare by fish-hunting cone snails Proceedings of the National Academy of Sciences of the United States of America 112(6):1743-1748.



Henning Gram Hansen, Cecilie Lützen Søltoft, Jonas Damgård Schmidt, Julia Birk, Christian Appenzeller-Herzog and Lars Ellgaard. (2014) Biochemical evidence that regulation of Ero1ß activity in human cells does not involve the isoform-specific cysteine 262 Bioscience Reports 34(2).


Michael Henrik Hagemann-Jensen, Franziska Katharina Uhlenbrock, Stephanie Kehlet, Lars Andresen, Charlotte Gabel-Jensen, Lars Ellgaard, Bente Gammelgaard and Søren Skov. (2014) The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D The Journal of Biological Chemistry 289:31576-31590.


Thomas Ramming, Henning Gram Hansen, Kazuhiro Nagata, Lars Ellgaard and Christian Appenzeller-Herzog. (2014) GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum Free Radical Biology & Medicine 70:106-116.



Emily M. Lynes, Michael Bui, Megan C. Yap, Matthew D. Benson, Bobbie Schneider, Lars Ellgaard, Luc G. Berthiaume and Thomas Simmen. (2012) Palmitoylated TMX and calnexin target to the mitochondria-associated membrane E M B O Journal 31(2):457-470.


Esben G Poulsen, Cornelia Steinhauer, Michael Lees, Anne-Marie Lauridsen, Lars Ellgaard and Rasmus Hartmann-Petersen. (2012) HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin P L o S One 7(11).


Franziska Kriegenburg, Lars Ellgaard and Rasmus Hartmann-Petersen. (2012) Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation F E B S Journal 279(4):532-542.


Henning Gram Hansen, Jonas Damgård Schmidt, Cecilie Lützen Søltoft, Thomas Ramming, Henrik Marcus Geertz-Hansen, Brian Christensen, Esben Skipper Sørensen, Agnieszka Juncker, Christian Andreas Appenzeller and L (2012) Hyperactivity of the Ero1a oxidase elicits endoplasmic reticulum stress but no broad antioxidant response Journal of Biological Chemistry 287(47):39513-39523.


Lea Cecilie Christensen, Njal Winther Jensen, Andrea Lages Lino Vala, Jurate Kamarauskaite, Linda Christina Johansson, Jakob R. Winther, Kay Hofmann, Kaare Teilum and Lars Ellgaard. (2012) The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region Journal of Biological Chemistry 287(31):26388-26399.



Jan Riemer, Henning G Hansen, C. Appenzeller-Herzog, Christian Appenzeller-Herzog, Linda Johansson and Lars Ellgaard. (2011) Identification of the PDI-family member ERp90 as an interaction partner of ERFAD P L o S One 6(2).


Louise Madsen, Franziska Kriegenburg, Andrea Lages Lino Vala, Diana Best, Søren Prag, Kay Hofmann, Michael Seeger, Ian R Adams and Rasmus Hartmann-Petersen. (2011) The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins P L o S One 6(9).


Neil J Bulleid and Lars Ellgaard. (2011) Multiple ways to make disulfides Trends in Biochemical Sciences 36(9):485-92.



Christian Appenzeller-Herzog, Jan Riemer, Ester Zito, King-Tung Chin, David Ron, Martin Spiess and Lars Ellgaard. (2010) Disulphide production by Ero1a-PDI relay is rapid and effectively regulated EMBO Journal 29(19):3318-29.


Doris Roth, Emily Lynes, Jan Riemer, Henning Gram Hansen, Nils Althaus, Thomas Simmen and Lars Ellgaard. (2010) A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4 Biochemical Journal 425(1):195-205.


Ryan Chao, Linda Nevin, Pooja Agarwal, Jan Riemer, Xiaoyang Bai, Allen Delaney, Matthew Akana, Nelson JimenezLopez, Tanya Bardakjian, Adele Schneider, Nicolas Chassaing, Daniel F Schorderet, Davi (2010) A male with unilateral microphthalmia reveals a role for TMX3 in eye development PLoS ONE 5(5):e10565.



Jan Riemer, Christian Appenzeller-Herzog, Linda Johansson, Bernd Bodenmiller, Rasmus Hartmann-Petersen and Lars Ellgaard. (2009) A luminal flavoprotein in endoplasmic reticulum-associated degradation Proceedings of the National Academy of Science of the United States of America 106(35):14831-6.



Christian Appenzeller-Herzog and Lars Ellgaard. (2008) In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms Antioxidants & Redox Signaling 10(1):55-64.


Christian Appenzeller-Herzog, Jan Riemer, Brian Christensen, Esben B. Sørensen and Lars Ellgaard. (2008) A novel disulphide switch mechanism in Ero1 balances ER oxidation in human cells EMBO Journal 27:2977–2987.



Christian Appenzeller-Herzog and Lars Ellgaard. (2007) The human PDI family: Versatility packed into a single fold. BBA General Subjects.


Johannes Haugstetter, Maurer Michael, Thomas Blicher, Martin Pagac, Gerhard Wider and Lars Ellgaard. (2007) Structure-function analysis of the ER oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain Journal of Biological Chemistry 280(46):33859-33867.


Mario Schelhaas, Johan Malmström, Lucas Pelkmans, Johannes Haugstetter, Lars Ellgaard, Kay Grünewald and Ari Helenius. (2007) Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell 131(3):516-29.



M. S. Kulp, E. M. Frickel, Lars Ellgaard and J. S. Weismann. (2006) Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. Journal of Biological Chemistry 281(2):876-84..

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