Protein sequence-function relationship studies by means of genetics and chemical biology

Main area:Protein chemistry
Target group:Biochemistry, Biology, Molecular Biomedicine
Educational level:Bachelor, Masters
Project description:

We are developing methods for geneticly assaying the stability of proteins in E. coli and yeast. These methods allow us to, in principle, determine the in vivo stability of any protein in vivo. We are using these methods to stabilize designed proteins.

At the same time we whish to combine chemically synthesized peptides in the analysis of protein stability in vitro.

Methods used:Molecular biology, fluorescence techniques, protein purification and characterization, ITC
Project home page: http://www1.bio.ku.dk/english/research/bms/research/pde/
Supervisor(s): Jakob Winther
Email:jrwinther@bio.ku.dk