Coordination of organ growth: principles and outstanding questions from the world of insects

Research output: Contribution to journalReviewpeer-review

In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

Original languageEnglish
JournalTrends in Cell Biology
Volume23
Issue number7
Pages (from-to)336-44
Number of pages9
ISSN0962-8924
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Bibliographical note

Copyright © 2013 Elsevier Ltd. All rights reserved.

    Research areas

  • Animals, Drosophila/growth & development, Drosophila Proteins/metabolism, Ecdysone/metabolism, Fat Body/growth & development, Imaginal Discs/growth & development, Larva/growth & development, Models, Biological, Signal Transduction/physiology

ID: 212683019