Des insulines pour orchestrer la croissance

Research output: Contribution to journalReviewpeer-review

Body size is an intrinsic property of living organisms that is intimately linked to the developmental program to produce fit individuals with proper proportions. Final size is the result of both genetic determinants and sophisticated mechanisms adapting size to available resources. Even though organs grow according to autonomous programs, some coordination mechanisms ensure that the different body parts adjust their growth with the rest of the body. In Drosophila, Dilp8, a hormone of the Insulin/Relaxin family is a key player in this inter-organs coordination and is required together with its receptor Lgr3 to limit developmental variability. Recently, the transcriptional co-activator Yki (homologue of YAP/TAZ factors in mammals) was shown to regulate dilp8 expression and contribute to the coordination of organ growth in Drosophila.

Translated title of the contributionSome insulins to orchestrate growth
Original languageFrench
JournalMedecine Sciences
Volume33
Issue number6-7
Pages (from-to)637-641
Number of pages5
ISSN0767-0974
DOIs
Publication statusPublished - 11 Oct 2017
Externally publishedYes

Bibliographical note

© 2017 médecine/sciences – Inserm.

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