Section for Molecular Integrative Physiology

The section includes researchers working on biomembranes, physical activity and adaptation, and various epithelia. The overall aim of the physiology section is to integrate the information from molecular level to complex organism level.

The preparations include various heterologous expression systems in yeast, oocytes, cell lines, as well as preparation from amphibia, genetically modified mice, rats and human subjects. Together, the physiology section utilizes a battery of techniques including molecular and protein biology, electrophysiology, bioimaging and computational models.

We are studying protein structure, function and regulation of P-type ATPases, ion channels, receptors and amino acid transporters at the molecular level. Projects include expression, purification and structural studies of membrane transporters, studies of their role in signal transduction and cell cycle regulation of the corresponding genes.

Physical activity and cellular adaptation
We are interested in understanding the effects of physical activity on cellular adaptations in skeletal muscle, adipose tissue and brain. The research focus on membrane transport and metabolism, and adaptive cellular responses are studied at the gene, protein and activity level using both human and animal models.

We are studying exocrine glands, gastrointestinal tract, kidney, respiratory tract and skin, and are interested in elucidating molecular and cellular mechanisms of ion and water transport and their integration in the physiology of the organism. Projects include study of various membrane transporters (CI- and K+ channels, H+ pumps, phosphate transporters, aquaporins), acid base transport, Ca2+ homeostasis, solute coupled water transport, and their regulation by various receptor signalling pathways.