Mathias Middelboe

Mathias Middelboe

Professor


  1. 2023
  2. Published

    Hydrostatic pressure induces transformations in the organic matter and microbial community composition of marine snow particles

    Stief, P., Schauberger, C., Becker, K. W., Elvert, M., Balmonte, J. P., Franco-Cisterna, B., Middelboe, Mathias & Glud, R. N., 2023, In: Communications Earth and Environment. 4, 1, 14 p., 377.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Staying below the Radar: Unraveling a New Family of Ubiquitous “Cryptic” Non-Tailed Temperate Vibriophages and Implications for Their Bacterial Hosts

    Kalatzis, P. G., Mauritzen, Jesper Juel, Winther-Have, Caroline Sophie W, Michniewski, S., Millard, A., Tsertou, M. I., Katharios, P. & Middelboe, Mathias, 2023, In: International Journal of Molecular Sciences. 24, 4, 23 p., 3937.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Strain-specific quorum-sensing responses determine virulence properties in Vibrio anguillarum

    Mauritzen, Jesper Juel, Søndberg, E., Kalatzis, Panagiotis, Roager, L., Gram, L., Svenningsen, Sine Lo & Middelboe, Mathias, 2023, In: Environmental Microbiology. 25, 7, 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. 2022
  6. Published

    In Vitro Evolution of Specific Phages Infecting the Fish Pathogen Flavobacterium psychrophilum

    Castillo, D., Højsting, A. R., Roosvall, A., Smyrlis, G., Jørgensen, J. & Middelboe, Mathias, 2022, In: PHAGE: Therapy, Applications, and Research. 3, 1, p. 28-37 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    On Single-Cell Enzyme Assays in Marine Microbial Ecology and Biogeochemistry

    Traving, Sachia Jo, Balmonte, J. P., Seale, D., Arnosti, C., Glud, R. N., Hallam, S. J. & Middelboe, Mathias, 2022, In: Frontiers in Marine Science. 9, 9 p., 846656.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Prevalence of genetically similar Flavobacterium columnare phages across aquaculture environments reveals a strong potential for pathogen control

    Runtuvuori-Salmela, A., Kunttu, H. M. T., Laanto, E., Almeida, G. M. F., Mäkelä, K., Middelboe, Mathias & Sundberg, L., 2022, In: Environmental Microbiology. 24, 5, p. 2404-2420 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Reversible mutations in gliding motility and virulence genes: A flexible and efficient phage defence mechanism in Flavobacterium psychrophilum

    Jørgensen, J., Sundell, K., Castillo, D., Dramshøj, L. S., Jørgensen, N. B., Madsen, S. B., Landor, L., Wiklund, T., Donati, V. L., Madsen, L., Dalsgaard, I. & Middelboe, Mathias, 2022, In: Environmental Microbiology. 24, 10, p. 4915-4930

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    The Gut Microbiota of Healthy and Flavobacterium psychrophilum-Infected Rainbow Trout Fry Is Shaped by Antibiotics and Phage Therapies

    Donati, V. L., Madsen, L., Middelboe, Mathias, Strube, M. L. & Dalsgaard, I., 2022, In: Frontiers in Microbiology. 13, 21 p., 771296.

    Research output: Contribution to journalJournal articlepeer-review

  11. 2021
  12. Published

    Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System

    Kunttu, H. M. T., Runtuvuori-Salmela, A., Sundell, K., Wiklund, T., Middelboe, Mathias, Landor, L., Ashrafi, R., Hoikkala, V. & Sundberg, L., 2021, In: Applied and Environmental Microbiology. 87, 16, 19 p., e00812-21 .

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Comparative Genomic Analyses of Flavobacterium psychrophilum Isolates Reveals New Putative Genetic Determinants of Virulence Traits

    Castillo, D., Donati, V. L., Jørgensen, J., Sundell, K., Dalsgaard, I., Madsen, L., Wiklund, T. & Middelboe, Mathias, 2021, In: Microorganisms. 9, 8, 15 p., 1658.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Comparison of Delivery Methods in Phage Therapy against Flavobacterium columnare Infections in Rainbow Trout

    Kunttu, H. M. T., Runtuvuori-Salmela, A., Middelboe, Mathias, Clark, J. & Sundberg, L. R., 2021, In: Antibiotics. 10, 8, 19 p., 914.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Dynamics of Baltic Sea phages driven by environmental changes

    Hoetzinger, M., Nilsson, E., Arabi, R., Osbeck, C. M. G., Pontiller, B., Hutinet, G., Bayfield, O. W., Traving, S., Kisand, V., Lundin, D., Pinhassi, J., Middelboe, Mathias & Holmfeldt, K., 2021, In: Environmental Microbiology. 23, 8, p. 4576-4594 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Genome-informed approach to identify genetic determinants of Flavobacterium psychrophilum phage susceptibility

    Castillo, D., Jørgensen, J., Sundell, K., Madsen, L., Dalsgaard, I., Wiklund, T. & Middelboe, Mathias, 2021, In: Environmental Microbiology. 23, 8, p. 4185-4199 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Genomic Analysis of Pasteurella atlantica Provides Insight on Its Virulence Factors and Phylogeny and Highlights the Potential of Reverse Vaccinology in Aquaculture

    Ellul, R. M., Kalatzis, Panagiotis, Frantzen, C., Haugland, G. T., Gulla, S., Colquhoun, D. J., Middelboe, Mathias, Wergeland, H. I. & Rønneseth, A., 2021, In: Microorganisms. 9, 6, 22 p., 1215.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Interactions between Rainbow Trout Eyed Eggs and Flavobacterium spp. Using a Bath Challenge Model: Preliminary Evaluation of Bacteriophages as Pathogen Control Agents

    Donati, V. L., Dalsgaard, I., Runtuvuori-Salmela, A., Kunttu, H., Jørgensen, J., Castillo, D., Sundberg, L., Middelboe, Mathias & Madsen, L., 2021, In: Microorganisms. 9, 5, 31 p., 971.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Interactions between the Prophage 919TP and Its Vibrio cholerae Host: Implications of gmd Mutation for Phage Resistance, Cell Auto-Aggregation, and Motility

    Li, N., Zeng, Y., Hu, B., Zhu, T., Svenningsen, Sine Lo, Middelboe, Mathias & Tan, D., 2021, In: Viruses. 13, 12, 15 p., 2342.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Phage-Mediated Control of Flavobacterium psychrophilum in Aquaculture: In vivo Experiments to Compare Delivery Methods

    Donati, V. L., Dalsgaard, I., Sundell, K., Castillo, D., Er-Rafik, M., Clark, J., Wiklund, T., Middelboe, Mathias & Madsen, L., 2021, In: Frontiers in Microbiology. 12, 16 p., 628309.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Spatial variability of prokaryotic and viral abundances in the Kermadec and Atacama Trench regions

    Schauberger, C., Middelboe, Mathias, Larsen, M., Peoples, L. M., Bartlett, D. H., Kirpekar, F., Rowden, A. A., Wenzhöfer, F., Thamdrup, B. & Glud, R. N., 2021, In: Limnology and Oceanography. 66, 6, p. 2095-2109 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. 2020
  23. Published

    Bacteriophages: Emerging Applications in Medicine, Food, and Biotechnology

    Sohail, H. A., Coffey, A., Debrowska, K., Meyer, I. M., Middelboe, Mathias, Sohail, M. & Clokie, M. R. J., 2020, In: PHAGE: Therapy, Applications, and Research. 1, 2, p. 75-82 8 p.

    Research output: Contribution to journalConference articlepeer-review

  24. Published

    Bacteriophages as Biocontrol Agents for Flavobacterium psychrophilum Biofilms and Rainbow Trout Infections

    Sundell, K., Landor, L., Castillo, D., Middelboe, Mathias & Wiklund, T., 2020, In: PHAGE: Therapy, Applications, and Research. 1, 4, p. 198-204 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Beyond Cholera: Characterization of zot-Encoding Filamentous Phages in the Marine Fish Pathogen Vibrio anguillarum

    Mauritzen, Jesper Juel, Castillo, D., Tan, D., Svenningsen, Sine Lo & Middelboe, Mathias, 2020, In: Viruses. 12, 7, 17 p., 730.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    High cell densities favor lysogeny: induction of an H20 prophage is repressed by quorum sensing and enhances biofilm formation in Vibrio anguillarum

    Tan, D., Hansen, Mads Frederik, de Carvalho, L. N., Røder, Henriette Lyng, Burmølle, Mette, Middelboe, Mathias & Svenningsen, Sine Lo, 2020, In: The ISME Journal. 14, 7, p. 1731-1742 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Sharp contrasts between freshwater and marine microbial enzymatic capabilities, community composition, and DOM pools in a NE Greenland fjord

    Balmonte, J. P., Hasler-Sheetal, H., Glud, R. N., Andersen, Thorbjørn Joest, Sejr, M. K., Middelboe, Mathias, Teske, A. & Arnosti, C., 2020, In: Limnology and Oceanography. 65, 1, p. 77-95 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. 2019
  29. Published

    P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

    Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Big Impact of the Tiny: Bacteriophage–Bacteria Interactions in Biofilms

    Hansen, Mads Frederik, Svenningsen, Sine Lo, Røder, Henriette Lyng, Middelboe, Mathias & Burmølle, Mette, 2019, In: Trends in Microbiology. 27, 9, p. 739-752 14 p.

    Research output: Contribution to journalReviewpeer-review

  31. Published

    Biological transformation of Arctic dissolved organic matter in a NE Greenland fjord

    Paulsen, M. L., Müller, O., Larsen, A., Møller, E. F., Middelboe, Mathias, Sejr, M. K. & Stedmon, C., 2019, In: Limnology and Oceanography. 64, 3, p. 1014-1033

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Combining probiotic Phaeobacter inhibens DSM17395 and broad-host-range vibriophage KVP40 against fish pathogenic vibrios

    Rasmussen, B. B., Kalatzis, Panagiotis, Middelboe, Mathias & Gram, L., 2019, In: Aquaculture. 513, 7 p., 734415.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Complete Genome Sequence of Vibrio anguillarum Nontailed Bacteriophage NO16

    Kalatzis, Panagiotis, Carstens, A. B., Katharios, P., Castillo, D., Hansen, L. H. & Middelboe, Mathias, 2019, In: Microbiology resource announcements. 8, 15, p. 1-2 e00020-19.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Effects of allochthonous dissolved organic matter input on microbial composition and nitrogen-cycling genes at two contrasting estuarine sites

    Happel, E. M., Markussen, T. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Middelboe, Mathias, Kisand, V. & Riemann, Lasse, 2019, In: F E M S Microbiology Ecology. 95, 9, 10 p., fiz123.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Large Phenotypic and Genetic Diversity of Prophages Induced from the Fish Pathogen Vibrio anguillarum

    Castillo, D., Andersen, N., Kalatzis, Panagiotis & Middelboe, Mathias, 2019, In: Viruses. 11, 11, 15 p., 983.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Phage defense mechanisms and their genomic and phenotypic implications in the fish pathogen Vibrio anguillarum

    Castillo, D., Rørbo, N., Jørgensen, J., Lange, J., Tan, D., Kalatzis, Panagiotis, Svenningsen, Sine Lo & Middelboe, Mathias, 2019, In: FEMS Microbiology Ecology. 95, 3, fiz004.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Phenotypic and Genetic Predictors of Pathogenicity and Virulence in Flavobacterium psychrophilum

    Sundell, K., Landor, L., Nicolas, P., Jørgensen, J., Castillo, D., Middelboe, Mathias, Dalsgaard, I., Donati, V. L., Madsen, L. & Wiklund, T., 2019, In: Frontiers in Microbiology. 10, 14 p., 1711.

    Research output: Contribution to journalJournal articlepeer-review

  38. 2018
  39. Published

    Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy

    Kalatzis, Panagiotis, Castillo Bermúdez, D. E., Katharios, P. & Middelboe, Mathias, 2018, In: Antibiotics. 7, 1, 23 p., 15.

    Research output: Contribution to journalReviewpeer-review

  40. Published

    Coupling biogeochemical process rates and metagenomic blueprints of coastal bacterial assemblages in the context of environmental change

    Markussen, T. M., Happel, E. M., Teikari, J. E., Huchaiah, V., Alneberg, J., Andersson, A. F., Sivonen, K., Riemann, Lasse, Middelboe, Mathias & Kisand, V., 2018, In: Environmental Microbiology. 20, 8, p. 3083-3099

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Draft Genome Sequences of Six Vibrio diazotrophicus Strains Isolated from Deep Subsurface Sediments of the Baltic Sea

    Castillo, D., Vandieken, V., Engelen, B., Engelhardt, T. & Middelboe, Mathias, 2018, In: Genome Announcements. 6, 10, p. 1-2 e00081-18.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Exploring the Effect of Phage Therapy in Preventing Vibrio anguillarum Infections in Cod and Turbot Larvae

    Rørbo, N. I., Rønneseth, A., Kalatzis, Panagiotis, Rasmussen, B. B., Engell-Sørensen, K., Kleppen, H. P., Wergeland, H. I., Gram, L. & Middelboe, Mathias, 2018, In: Antibiotics. 7, 2, 15 p., 42.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Widespread distribution of prophage-encoded virulence factors in marine Vibrio communities

    Castillo, D., Kauffman, K., Hussain, F., Kalatzis, Panagiotis, Rørbo, N., Polz, M. F. & Middelboe, Mathias, 2018, In: Scientific Reports. 8, p. 1-9 9973.

    Research output: Contribution to journalJournal articlepeer-review

  44. 2017
  45. Published

    Isolation and characterization of a N4-like lytic bacteriophage infecting Vibrio splendidus, a pathogen of fish and bivalves

    Katharios, P., Kalatzis, Panagiotis, Kokkari, C., Sarropoulou, E. & Middelboe, Mathias, 28 Dec 2017, In: PLoS ONE. 12, 12, 14 p., e0190083.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Marine viruses: key players in marine ecosystems

    Middelboe, Mathias & Brussaard, C. P. D., Oct 2017, In: Viruses. 9, 10, 6 p., 302.

    Research output: Contribution to journalEditorial

  47. Published

    Stumbling across the same phage: comparative genomics of widespread temperate phages infecting the fish pathogen Vibrio anguillarum

    Kalatzis, Panagiotis, Rørbo, N. I., Castillo Bermúdez, D. E., Mauritzen, Jesper Juel, Jørgensen, J., Kokkari, C., Zhang, F., Katharios, P. & Middelboe, Mathias, 20 May 2017, In: Viruses. 9, 5, 19 p., 122.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Comparative genome analyses of Vibrio anguillarum strains reveal a link with pathogenicity traits

    Castillo Bermúdez, D. E., Alvise, P. D., Xu, R., Zhang, F., Middelboe, Mathias & Gram, L., 28 Feb 2017, In: mSystems. 2, 1, 14 p., e00001-17.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Carbon bioavailability in a high arctic fjord influenced by glacial meltwater, NE Greenland

    Paulsen, M. L., Nielsen, S. E. B., Müller, O., Møller, E. F., Stedmon, C. A., Juul-Pedersen, T., Markager, S., Sejr, M. K., Delgado Huertas, A., Larsen, A. & Middelboe, Mathias, 2017, In: Frontiers in Marine Science. 4, 19 p., 176.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis

    Sonnenschein, E. C., Nielsen, K. F., D'Alvise, P., Porsby, C. H., Melchiorsen, J., Heilmann, J., Kalatzis, Panagiotis, López-Pérez, M., Bunk, B., Spröer, C., Middelboe, Mathias & Gram, L., 2017, In: The ISME Journal. 11, p. 569-583 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. 2016
  52. Published

    Benthic carbon mineralization in hadal trenches: assessment by in situ O2 microprofile measurements

    Wenzhöfer, F., Oguri, K., Middelboe, Mathias, Turnewitsch, R., Toyofuku, T., Kitazato, H. & Glud, R. N., 2016, In: Deep-Sea Research. Part 1: Oceanographic Research Papers. 116, p. 276-286 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Comparative genome analysis provides Insights into the pathogenicity of Flavobacterium psychrophilum

    Castillo Bermúdez, D. E., Christiansen, R. H., Dalsgaard, I., Madsen, L., Espejo, R. & Middelboe, Mathias, 2016, In: P L o S One. 11, 4, 18 p., e0152515.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    Effect of bacteriophages on the growth of Favobacterium psychrophilum and development of phage-resistant strains

    Christiansen, R. H., Madsen, L., Dalsgaard, I., Castillo Bermúdez, D. E., Kalatzis, P. G. & Middelboe, Mathias, 2016, In: Microbial Ecology. 71, 4, p. 845-859 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Genomic diversity of bacteriophages infecting the fish pathogen Flavobacterium psychrophilum

    Castillo Bermúdez, D. E. & Middelboe, Mathias, 2016, In: F E M S Microbiology Letters. 363, 24, 6 p., fnw272.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Predation and selection for antibiotic resistance in natural environments

    Leisner, Jørgen, Jørgensen, Niels O. G. & Middelboe, Mathias, 2016, In: Evolutionary Applications (Online). 9, 3, p. 427-434 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Quantification of viral and prokaryotic production rates in benthic ecosystems: a methods comparison

    Rastelli, E., Dell'Anno, A., Corinaldesi, C., Middelboe, Mathias, Noble, R. T. & Danovaro, R., 2016, In: Frontiers in Microbiology. 7, 11 p., 1501.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Re-examination of the relationship between marine virus and microbial cell abundances

    Wigington, C. H., Sonderegger, D., Brussaard, C. P. D., Buchan, A., Finke, J. F., Fuhrman, J. A., Lennon, J. T., Middelboe, Mathias, Suttle, C. A., Wilson, W. H., Wommack, K. E., Wilhelm, S. W. & Weitz, J. S., 2016, In: Nature Microbiology. 1, 8 p., 15024 .

    Research output: Contribution to journalJournal articlepeer-review

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