Conservative route to genome compaction in a miniature annelid

Research output: Contribution to journalJournal articleResearchpeer-review

Documents

  • José M. Martín-Durán
  • Bruno C. Vellutini
  • Ferdinand Marlétaz
  • Viviana Cetrangolo
  • Nevena Cvetesic
  • Daniel Thiel
  • Simon Henriet
  • Xavier Grau-Bové
  • Allan M. Carrillo-Baltodano
  • Wenjia Gu
  • Alexandra Kerbl
  • Yamile Marquez
  • Nicolas Bekkouche
  • Daniel Chourrout
  • Jose Luis Gómez-Skarmeta
  • Manuel Irimia
  • Boris Lenhard
  • Worsaae, Katrine
  • Andreas Hejnol

The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact 73.8-megabase genome of Dimorphilus gyrociliatus, a meiobenthic segmented worm. The D. gyrociliatus genome retains traits classically associated with larger and slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental toolkit and traces of ancestral bilaterian linkage. Unlike some other animals with small genomes, the analysis of the D. gyrociliatus epigenome revealed canonical features of genome regulation, excluding the presence of operons and trans-splicing. Instead, the gene-dense D. gyrociliatus genome presents a divergent Myc pathway, a key physiological regulator of growth, proliferation and genome stability in animals. Altogether, our results uncover a conservative route to genome compaction in annelids, reminiscent of that observed in the vertebrate Takifugu rubripes.

Original languageEnglish
JournalNature Ecology and Evolution
Volume5
Issue number2
Pages (from-to)231-242
ISSN2397-334X
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Correction: Conservative route to genome compaction in a miniature annelid DOI: 10.1038/s41559-020-01366-z

ID: 252679447