Per Amstrup Pedersen

Per Amstrup Pedersen

Associate Professor

ORCID: 0000-0001-8648-9748

Publication year:
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  1. 2024
  2. Published

    Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases

    Guo, Zongxin, Orädd, F., Bågenholm, Viktoria, Grønberg, C., Ma, J. F., Ott, P., Wang, Y., Andersson, M., Pedersen, Per Amstrup, Wang, Kaituo & Gourdon, Pontus Emanuel, 2024, In: Nature Communications. 15, 1, 16 p., 2690.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling

    Ghiasi, S. M., Christensen, Nynne, Pedersen, Per Amstrup, Skovhøj, Emil Zeng & Novak, Ivana, 2024, In: Cellular Signalling. 117, 12 p., 111109.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    pXOOY: A dual-function vector for expression of membrane proteins in Saccharomyces cerevisiae and Xenopus laevis oocytes

    Vold, Victoria Amstrup, Glanville, S., Klærke, Dan Arne & Pedersen, Per Amstrup, 2023, In: PLoS ONE. 18, 2, 16 p., e0281868.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2022
  7. Published

    Isolation and Crystallization of the D156C Form of Optogenetic ChR2

    Zhang, L., Wang, Kaituo, Ning, S., Pedersen, Per Amstrup, Duelli, A. S. & Gourdon, Pontus Emanuel, 2022, In: Cells. 11, 5, 11 p., 895.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

    Merklinger, L., Bauer, J., Pedersen, Per Amstrup, Damgaard, R. B. & Morth, J. P., 2022, In: Life Science Alliance. 5, 8, 13 p., e202101309.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Production of an Active, Human Membrane Protein in Saccharomyces cerevisiae: Full-Length FICD

    Virolainen, M. S., Søltoft, C. L., Pedersen, Per Amstrup & Ellgaard, Lars, 2022, In: International Journal of Molecular Sciences. 23, 5, 17 p., 2458.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The role of water coordination in the pH-dependent gating of hAQP10

    Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2021
  12. Published

    Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins

    Preisler, Sarah Spruce, Wiuf, A. D., Friis, M., Kjaergaard, L., Hurd, M., Becares, E. R., Nurup, C. N., Bjoerkskov, F. B., Szathmáry, Z., Gourdon, Pontus Emanuel, Callø, Kirstine, Klærke, Dan Arne, Gotfryd, K. & Pedersen, Per Amstrup, 2021, In: Current research in structural biology. 3, p. 51-71 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations

    Pimpão, C., Wragg, D., Bonsignore, R., Aikman, B., Pedersen, Per Amstrup, Leoni, S., Soveral, G. & Casini, A., 2021, In: Metallomics. 13, 9, 11 p., mfab053.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Occipital Horn Syndrome as a Result of Splice Site Mutations in ATP7A. No Activity of ATP7A Splice Variants Missing Exon 10 or Exon 15

    Møller, L. B., Mogensen, M., Weaver, D. D. & Pedersen, Per Amstrup, 2021, In: Frontiers in Molecular Neuroscience. 14, 12 p., 532291.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Order and disorder - An integrative structure of the full-length human growth hormone receptor

    Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Yong, Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Overproduction of Human Zip (SLC39) Zinc Transporters in Saccharomyces cerevisiae for Biophysical Characterization

    Becares, E. R., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2021, In: Cells. 10, 2, 21 p., 213.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Recombinant production of membrane proteins in yeast

    Preisler, Sarah Spruce, Hansen, K. M., Nurup, C. N., Beich-Frandsen, M. & Pedersen, Per Amstrup, 2021, Methods in Enzymology. Pyle, A. M. & Christianson, D. W. (eds.). Academic Press, Vol. 660. p. 21-52 32 p. (Methods in Enzymology, Vol. 660).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  18. 2020
  19. Published

    Purification and initial characterization of Plasmodium falciparum K+ channels, PfKch1 and PfKch2 produced in Saccharomyces cerevisiae

    Molbaek, K., Tejada, M., Ricke, C. H., Scharff-Poulsen, P., Ellekvist, P., Helix-Nielsen, C., Kumar, N., Klærke, Dan Arne & Pedersen, Per Amstrup, 2020, In: Microbial Cell Factories. 19, 1, 183.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The rapid “teabag” method for high-end purification of membrane proteins

    Hering, J., Missel, Julie Winkel, Zhang, L., Gunnarsson, A., Castaldo, M., Pedersen, Per Amstrup, Ek, M., Gourdon, Pontus Emanuel & Snijder, H. J., 2020, In: Scientific Reports. 10, 11 p., 16167.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies

    Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. 2019
  23. Published

    Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism

    Muncanovic, D., Justesen, M. H., Preisler, Sarah Spruce & Pedersen, Per Amstrup, 2019, In: Scientific Reports. 9, 25 p., 12442.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Human aquaporin-5 facilitates hydrogen peroxide permeation affecting adaption to oxidative stress and cancer cell migration

    Rodrigues, C., Pimpão, C., Mósca, A. F., Coxixo, A. S., Lopes, D., Da Silva, I. V., Pedersen, Per Amstrup, Antunes, F. & Soveral, G., 2019, In: Cancers. 11, 7, 17 p., 932.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Purification of Functional Human TRP Channels Recombinantly Produced in Yeast

    Zhang, L., Wang, Kaituo, Klærke, Dan Arne, Callø, Kirstine, Lowrey, L., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2019, In: Cells. 8, 2, p. 1-20 148.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Structure of the human ClC-1 chloride channel

    Wang, Kaituo, Preisler, Sarah Spruce, Zhang, L., Cui, Y., Missel, Julie Winkel, Grønberg, C., Gotfryd, K., Lindahl, E., Andersson, M., Callø, Kirstine, Egea, P. F., Klærke, Dan Arne, Pusch, M., Pedersen, Per Amstrup, Zhou, Z. H. & Gourdon, Pontus Emanuel, 2019, In: PLOS Biology. 17, 4, p. 1-20 e3000218.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2018
  28. Published

    From channel proteins to industrial biomimetic membrane technology

    Pedersen, Per Amstrup, Bjørkskov, F. B., Alvisse, S. & Hélix-Nielsen, C., 2018, In: Faraday Discussions. 209, p. 287-301 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Human AQP5 facilitates hydrogen peroxide permeation and improves cell resistance to oxidative stress

    Rodrigues, C., Mósca, A. F., Lopes, D., Pedersen, Per Amstrup, Antunes, F. & Soveral, G., 2018, In: Free Radical Biology and Medicine. 120, Suppl. 1, p. S70 P-86.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. Published

    Human adipose glycerol flux is regulated by a pH gate in AQP10

    Gotfryd, K., Mósca, A. F., Missel, Julie Winkel, Truelsen, S. F., Wang, Kaituo, Spulber, M., Krabbe, S., Hélix-nielsen, C., Laforenza, U., Soveral, G., Pedersen, Per Amstrup & Gourdon, Pontus Emanuel, 2018, In: Nature Communications. 9, p. 1-11 4749.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Reconstitution and Electrophysiological Characterization of Ion Channels in Lipid Bilayers

    Klærke, Dan Arne, Tejada, M. D. L. A., Christensen, V. G., Lassen, M., Pedersen, Per Amstrup & Callø, Kirstine, 2018, In: Current Protocols in Pharmacology. 81, 1, p. e37 17 p., e37.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2017
  33. Published

    Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization

    Bjørkskov, F. B., Krabbe, S., Nurup, C. N., Missel, Julie Winkel, Spulber, M., Bomholt, J., Molbaek, K., Helix-Nielsen, C., Gotfryd, K., Gourdon, Pontus Emanuel & Pedersen, Per Amstrup, 4 Dec 2017, In: Scientific Reports. 7, 21 p., 16899.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease

    Skjørringe, T., Pedersen, Per Amstrup, Thorborg, S. S., Nissen, P., Gourdon, Pontus Emanuel & Møller, L. B., 7 Apr 2017, In: Scientific Reports. 7, 18 p., 757.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Single-Channel Recordings of K+ Channels Expressed in Saccharomyces Cerevisiae

    Tejada, M. D. L. A., Molbaek, K., Cazimi, H., Ellekvist, P., Callø, Kirstine, Nielsen, C. H., Pedersen, Per Amstrup & Klærke, Dan Arne, 2017, In: Biophysical Journal. 112, 3, Suppl. 1, p. 406A 1 p., 2002-Pos Board B322.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  36. 2015
  37. Published

    High yield purification of full-length functional hERG K+ channels produced in Saccharomyces cerevisiae

    Hansen, K. M., Scharff-Poulsen, P., Hélix-Nielsen, C., Klærke, Dan Arne & Pedersen, Per Amstrup, 2015, In: Microbial Cell Factories. 14, 16 p., 15.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2014
  39. Published

    Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle

    Biensø, R. S., Knudsen, Jakob Grunnet, Brandt, N., Pedersen, Per Amstrup & Pilegaard, Henriette, 2014, In: Pflügers Archiv - European Journal of Physiology. 466, 8, p. 1647-1657 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Role of vesicular nucleotide transporter VNUT (SLC17A9) in release of ATP from AR42J cells and mouse pancreatic acinar cells

    Haanes, Kristian Agmund, Kowal, J. M., Arpino, G., Lange, S. C., Moriyama, Y., Pedersen, Per Amstrup & Novak, Ivana, 2014, In: Purinergic Signalling. 10, 3, p. 431-440 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    mTOR ensures increased release and reduced uptake of the organic osmolyte taurine under hypoosmotic conditions in mouse fibroblasts

    Lambert, Ian Henry, Jensen, J. V. & Pedersen, Per Amstrup, 2014, In: American Journal of Physiology: Cell Physiology. 306, 11, p. C1028-C1040 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. 2013
  43. Published

    Saccharomyces cerevisiae-based platform for rapid production and evaluation of Eukaryotic Nutrient transporters and transceptors for biochemical studies and crystallography

    Scharff-Poulsen, P. & Pedersen, Per Amstrup, 2013, In: PLoS ONE. 8, 10, 12 p., e76851.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    In vivo studies of aquaporins 3 and 10 in human stratum corneum

    Jungersted, J., Bomholt, J., Bajraktari, N., Hansen, J. S., Klærke, Dan Arne, Pedersen, Per Amstrup, Hedfalk, K., Nielsen, K. H., Agner, T. & Hélix-Nielsen, C., 2013, In: Archives of Dermatological Research. 305, 8, p. 699-704 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Recombinant Production of Human Aquaporin-1 to an Exceptional High Membrane Density in Saccharomyces cerevisiae

    Bomholt, J., Hélix-Nielsen, C., Scharff-Poulsen, P. & Pedersen, Per Amstrup, 2013, In: P L o S One. 8, 2, 9 p., e56431.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2011
  47. Published

    Role of PGC-1{alpha} in exercise and fasting induced adaptations in mouse liver

    Haase, T. N., Jørgensen, S. R., Leick, L., Biensø, R. S., Kiilerich, K., Johansen, S., Nielsen, M. M., Wojtaszewski, Jørgen F P, Hidalgo, J., Pedersen, Per Amstrup & Pilegaard, Henriette, 2011, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301, 5, p. R1501-R1509 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. 2010
  49. Published

    Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle

    Kiilerich, K., Gudmundsson, M., Birk, Jesper Bratz, Lundby, C., Taudorf, S., Plomgaard, Peter Stendahl, Saltin, B., Pedersen, Per Amstrup, Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: Diabetes. 59, 1, p. 26-32 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    PGC-1{alpha} increases PDH content but does not change acute PDH regulation in mouse skeletal muscle

    Kiilerich, K., Adser, H., Jakobsen, A. H., Pedersen, Per Amstrup, Hardie, D. G., Wojtaszewski, Jørgen F P & Pilegaard, Henriette, 2010, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 299, 5, p. R1350-R1359 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2006
  52. Published

    Heterologous Expression of Membrane and Soluble Proteins Derepresses GCN4 mRNA Translation in the Yeast Saccharomyces cerevisiae

    Steffensen, L. & Pedersen, Per Amstrup, 2006, In: Eukaryotic Cell. 5, 2, p. 248-261

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2005
  54. Published

    Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs

    Teilmann, S. C., Byskov, A. G., Pedersen, Per Amstrup, Wheatley, D. N., Pazour, G. J. & Christensen, Søren Tvorup, 2005, In: Molecular Reproduction and Development. 71, 4, p. 444-452

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Oprensning af sjældent forekommende membranproteiner

    Pedersen, Per Amstrup, 2005, Proteiner: oprensning og karakterisering. Kielberg, V. & Rasmussen, L. (eds.). 3. ed. København: Gyldendal, p. 67-76

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  56. Published

    Rekombinant fremstillede proteiner

    Pedersen, Per Amstrup, 2005, Proteiner: oprensning og karakterisering. Kielberg, V. & Rasmussen, L. (eds.). 3. ed. København: Gyldendal, p. 77-86

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  57. 2004
  58. Published

    Identification and partial characterization of Taastrup virus: a newly identified member species of the Monomegavirales

    Bock, J. O., Lundsgaard, T., Pedersen, Per Amstrup & Christensen, L. S., 2004, In: Virology. 319, p. 49-59

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. 2003
  60. Published

    Cloning, expression, purification and crystallization of the N-domain from the alpha(2) subunit of the membrane-spanning Na,K-ATPase protein

    Haue, L., Pedersen, Per Amstrup, Jorgensen, P. L. & Håkansson, K. O., Jul 2003, In: Acta crystallographica Section D: Structural biology . 59, Pt 7, p. 1259-61 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Amino Acids in the TM4-TM5 loop of Na,K-ATPase Are Important for Biosynthesis

    Jørgensen, J. R., Houghton-Larsen, J., Jacobsen, M. D. & Pedersen, Per Amstrup, 2003, In: Annals of the New York Academy of Sciences. 986, p. 369-377

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Cloning and characterisation of a glucoamylase gene (GlaM) from dimorphic zygomycete Mucor circinelloides

    Houghton-Larsen, J. & Pedersen, Per Amstrup, 2003, In: Applied Microbiology and Biotechnology. 62, 2-3, p. 210-217

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Functional expression of rat adenosine A1 receptor in the dimorphic zygomycete Mucor circinelloides

    Houghton-Larsen, J. & Pedersen, Per Amstrup, 2003, In: Appl. Microbiol. Biotechnol.. 63, p. 64-67

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Overexpression of SERCA1a Ca2+-ATPase in Yeast

    Falson, P., Lenoir, G., Menguy, T., Corre, F., Montigny, C., Pedersen, Per Amstrup, Thinès, D. & le Maire, M., 2003, In: Ann. N. Y. Acad. Sci.. 986, p. 312-314

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Responses at the Translational Level to Heterologous Expression of the Na,K-ATPase

    Steffensen, L. & Pedersen, Per Amstrup, 2003, In: Annals of the New York Academy of Sciences. 986, p. 539-540

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. 2002
  67. Published

    Importance of Na,K-ATPase Residueβ-1Arg544 in the Segment Arg544-ASP567 for High-Affinity Binding of ATP, ADP, or MgATP

    Jacobsen, M. D., Pedersen, Per Amstrup & Jorgensen, P. L., 2002, In: Biochemistry. 41, p. 1451-1456

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Overproduction in yeast and rapid and efficient purification of the rabbit SERCA1a Ca2+-ATPase

    Lenoir, G., Menguy, T., Corre, F., Montigny, C., Pedersen, Per Amstrup, Thinès, D., le Maire, M. & Falson, P., 2002, In: BBA General Subjects. 1560, p. 67-83

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 12553