Functions of TopBP1 in preserving genome integrity during mitosis

Research output: Contribution to journalReviewpeer-review

TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
Volume113
Pages (from-to)57-64
Number of pages8
ISSN1084-9521
DOIs
Publication statusPublished - 2021

    Research areas

  • Anaphase Bridges, Homologous recombination, MDC1, MiDAS, Mitosis, SLX4, TopBP1

ID: 249857994