Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis
Research output: Contribution to journal › Journal article › Research › peer-review
Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.
Original language | English |
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Journal | HLA |
Volume | 28 |
Issue number | 4 |
Pages (from-to) | 245-50 |
Number of pages | 5 |
ISSN | 2059-2302 |
Publication status | Published - 1986 |
Bibliographical note
Keywords: Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Denmark; Female; HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; HLA-DR5 Antigen; Histocompatibility Antigens Class II; Humans; Infant; Male
ID: 10638392