Membrane potential plays a dual role for chloride transport across toad skin

Research output: Contribution to journalJournal articlepeer-review

The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.
Original languageEnglish
JournalBBA General Subjects
Volume728
Issue number3
Pages (from-to)455-9
Number of pages5
ISSN0304-4165
Publication statusPublished - 9 Mar 1983

    Research areas

  • Animals, Biological Transport, Active, Bufo bufo, Cell Membrane, Chlorides, Computers, Epithelium, Kinetics, Membrane Potentials, Skin Physiological Phenomena

ID: 103932136