Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2
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- Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2
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The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
| Original language | English |
|---|---|
| Article number | 585358 |
| Journal | Frontiers in Medicine |
| Volume | 8 |
| Number of pages | 7 |
| ISSN | 2296-858X |
| DOIs | |
| Publication status | Published - 2021 |
- evolution, human to human transmission, intra-host variation, population bottleneck, SARS-CoV-2
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