Salmon gut microbiota correlates with disease infection status: potential for monitoring health in farmed animals

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Salmon gut microbiota correlates with disease infection status : potential for monitoring health in farmed animals. / Bozzi, Davide; Rasmussen, Jacob Agerbo; Carøe, Christian; Sveier, Harald; Nordøy, Kristian; Gilbert, M Thomas P; Limborg, Morten T.

In: BMC Animal Microbiome, Vol. 3, 30, 2021.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bozzi, D, Rasmussen, JA, Carøe, C, Sveier, H, Nordøy, K, Gilbert, MTP & Limborg, MT 2021, 'Salmon gut microbiota correlates with disease infection status: potential for monitoring health in farmed animals', BMC Animal Microbiome, vol. 3, 30. https://doi.org/10.1186/s42523-021-00096-2

APA

Bozzi, D., Rasmussen, J. A., Carøe, C., Sveier, H., Nordøy, K., Gilbert, M. T. P., & Limborg, M. T. (2021). Salmon gut microbiota correlates with disease infection status: potential for monitoring health in farmed animals. BMC Animal Microbiome, 3, [30]. https://doi.org/10.1186/s42523-021-00096-2

Vancouver

Bozzi D, Rasmussen JA, Carøe C, Sveier H, Nordøy K, Gilbert MTP et al. Salmon gut microbiota correlates with disease infection status: potential for monitoring health in farmed animals. BMC Animal Microbiome. 2021;3. 30. https://doi.org/10.1186/s42523-021-00096-2

Author

Bozzi, Davide ; Rasmussen, Jacob Agerbo ; Carøe, Christian ; Sveier, Harald ; Nordøy, Kristian ; Gilbert, M Thomas P ; Limborg, Morten T. / Salmon gut microbiota correlates with disease infection status : potential for monitoring health in farmed animals. In: BMC Animal Microbiome. 2021 ; Vol. 3.

Bibtex

@article{18fa85fbdfd3454fab8ad9b6fac8d3c2,
title = "Salmon gut microbiota correlates with disease infection status: potential for monitoring health in farmed animals",
abstract = "BackgroundInfectious diseases cause significant production losses in aquaculture every year. Since the gut microbiota plays an essential role in regulating the host immune system, health and physiology, altered gut microbiota compositions are often associated with a diseased status. However, few studies have examined the association between disease severity and degree of gut dysbiosis, especially when the gut is not the site of the primary infection. Moreover, there is a lack of knowledge on whether bath treatment with formalin, a disinfectant commonly used in aquaculture to treat external infections, might affect the gut microbiome as a consequence of formalin ingestion. Here we investigate, through 16S rRNA gene metabarcoding, changes in the distal gut microbiota composition of a captive-reared cohort of 80 Atlantic salmon (Salmo salar L.), in consequence of an external bacterial skin infection due to a natural outbreak and subsequent formalin treatment.ResultsWe identified Tenacibaculum dicentrarchi as the causative disease pathogen and we show that the distal gut of diseased salmon presented a different composition from that of healthy individuals. A new, yet undescribed, Mycoplasma genus characterized the gut of healthy salmon, while in the sick fish we observed an increase in terms of relative abundance of Aliivibrio sp., a strain regarded as opportunistic. We also noticed a positive correlation between fish weight and Mycoplasma sp. relative abundance, potentially indicating a beneficial effect for its host. Moreover, we observed that the gut microbiota of fish treated with formalin was more similar to those of sick fish than healthy ones.ConclusionsWe conclude that external Tenacibaculum infections have the potential of indirectly affecting the host gut microbiota. As such, treatment optimization procedures should account for that. Formalin treatment is not an optimal solution from a holistic perspective, since we observe an altered gut microbiota in the treated fish. We suggest its coupling with a probiotic treatment aimed at re-establishing a healthy community. Lastly, we have observed a positive correlation of Mycoplasma sp. with salmon health and weight, therefore we encourage further investigations towards its potential utilization as a biomarker for monitoring health in salmon and potentially other farmed fish species.",
author = "Davide Bozzi and Rasmussen, {Jacob Agerbo} and Christian Car{\o}e and Harald Sveier and Kristian Nord{\o}y and Gilbert, {M Thomas P} and Limborg, {Morten T.}",
year = "2021",
doi = "10.1186/s42523-021-00096-2",
language = "English",
volume = "3",
journal = "BMC Animal Microbiome",
issn = "2524-4671",

}

RIS

TY - JOUR

T1 - Salmon gut microbiota correlates with disease infection status

T2 - potential for monitoring health in farmed animals

AU - Bozzi, Davide

AU - Rasmussen, Jacob Agerbo

AU - Carøe, Christian

AU - Sveier, Harald

AU - Nordøy, Kristian

AU - Gilbert, M Thomas P

AU - Limborg, Morten T.

PY - 2021

Y1 - 2021

N2 - BackgroundInfectious diseases cause significant production losses in aquaculture every year. Since the gut microbiota plays an essential role in regulating the host immune system, health and physiology, altered gut microbiota compositions are often associated with a diseased status. However, few studies have examined the association between disease severity and degree of gut dysbiosis, especially when the gut is not the site of the primary infection. Moreover, there is a lack of knowledge on whether bath treatment with formalin, a disinfectant commonly used in aquaculture to treat external infections, might affect the gut microbiome as a consequence of formalin ingestion. Here we investigate, through 16S rRNA gene metabarcoding, changes in the distal gut microbiota composition of a captive-reared cohort of 80 Atlantic salmon (Salmo salar L.), in consequence of an external bacterial skin infection due to a natural outbreak and subsequent formalin treatment.ResultsWe identified Tenacibaculum dicentrarchi as the causative disease pathogen and we show that the distal gut of diseased salmon presented a different composition from that of healthy individuals. A new, yet undescribed, Mycoplasma genus characterized the gut of healthy salmon, while in the sick fish we observed an increase in terms of relative abundance of Aliivibrio sp., a strain regarded as opportunistic. We also noticed a positive correlation between fish weight and Mycoplasma sp. relative abundance, potentially indicating a beneficial effect for its host. Moreover, we observed that the gut microbiota of fish treated with formalin was more similar to those of sick fish than healthy ones.ConclusionsWe conclude that external Tenacibaculum infections have the potential of indirectly affecting the host gut microbiota. As such, treatment optimization procedures should account for that. Formalin treatment is not an optimal solution from a holistic perspective, since we observe an altered gut microbiota in the treated fish. We suggest its coupling with a probiotic treatment aimed at re-establishing a healthy community. Lastly, we have observed a positive correlation of Mycoplasma sp. with salmon health and weight, therefore we encourage further investigations towards its potential utilization as a biomarker for monitoring health in salmon and potentially other farmed fish species.

AB - BackgroundInfectious diseases cause significant production losses in aquaculture every year. Since the gut microbiota plays an essential role in regulating the host immune system, health and physiology, altered gut microbiota compositions are often associated with a diseased status. However, few studies have examined the association between disease severity and degree of gut dysbiosis, especially when the gut is not the site of the primary infection. Moreover, there is a lack of knowledge on whether bath treatment with formalin, a disinfectant commonly used in aquaculture to treat external infections, might affect the gut microbiome as a consequence of formalin ingestion. Here we investigate, through 16S rRNA gene metabarcoding, changes in the distal gut microbiota composition of a captive-reared cohort of 80 Atlantic salmon (Salmo salar L.), in consequence of an external bacterial skin infection due to a natural outbreak and subsequent formalin treatment.ResultsWe identified Tenacibaculum dicentrarchi as the causative disease pathogen and we show that the distal gut of diseased salmon presented a different composition from that of healthy individuals. A new, yet undescribed, Mycoplasma genus characterized the gut of healthy salmon, while in the sick fish we observed an increase in terms of relative abundance of Aliivibrio sp., a strain regarded as opportunistic. We also noticed a positive correlation between fish weight and Mycoplasma sp. relative abundance, potentially indicating a beneficial effect for its host. Moreover, we observed that the gut microbiota of fish treated with formalin was more similar to those of sick fish than healthy ones.ConclusionsWe conclude that external Tenacibaculum infections have the potential of indirectly affecting the host gut microbiota. As such, treatment optimization procedures should account for that. Formalin treatment is not an optimal solution from a holistic perspective, since we observe an altered gut microbiota in the treated fish. We suggest its coupling with a probiotic treatment aimed at re-establishing a healthy community. Lastly, we have observed a positive correlation of Mycoplasma sp. with salmon health and weight, therefore we encourage further investigations towards its potential utilization as a biomarker for monitoring health in salmon and potentially other farmed fish species.

U2 - 10.1186/s42523-021-00096-2

DO - 10.1186/s42523-021-00096-2

M3 - Journal article

C2 - 33879261

VL - 3

JO - BMC Animal Microbiome

JF - BMC Animal Microbiome

SN - 2524-4671

M1 - 30

ER -

ID: 260304901