The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

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DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.

Original languageEnglish
Article number107849
JournalCell Reports
Volume32
Issue number1
Number of pages25
ISSN2211-1247
DOIs
Publication statusPublished - 2020

    Research areas

  • D-loop dissociation, DNA helicase, FANCD2, FANCJ, FANCM, Fanconi anemia, homologous recombination, interstrand DNA crosslink repair, RAD51, sister-chromatid exchange

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