Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation

Research output: Contribution to journal › Letter › Research › peer-review

Standard

Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. / Zhao, Shancen; Zheng, Pingping; Dong, Shanshan; Zhan, Xiangjiang; Wu, Qi; Guo, Xiaosen; Hu, Yibo; He, Weiming; Zhang, Shanning; Fan, Wei; Zhu, Lifeng; Li, Dong; Zhang, Xuemei; Chen, Quan; Zhang, Hemin; Zhang, Zhihe; Jin, Xuelin; Zhang, Jinguo; Yang, Huanming; Wang, Jian; Wang, Jun; Wei, Fuwen.

In: Nature Genetics, Vol. 45, No. 1, 2013, p. 67-71.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Zhao, S, Zheng, P, Dong, S, Zhan, X, Wu, Q, Guo, X, Hu, Y, He, W, Zhang, S, Fan, W, Zhu, L, Li, D, Zhang, X, Chen, Q, Zhang, H, Zhang, Z, Jin, X, Zhang, J, Yang, H, Wang, J, Wang, J & Wei, F 2013, 'Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation', Nature Genetics, vol. 45, no. 1, pp. 67-71. https://doi.org/10.1038/ng.2494

APA

Zhao, S., Zheng, P., Dong, S., Zhan, X., Wu, Q., Guo, X., Hu, Y., He, W., Zhang, S., Fan, W., Zhu, L., Li, D., Zhang, X., Chen, Q., Zhang, H., Zhang, Z., Jin, X., Zhang, J., Yang, H., ... Wei, F. (2013). Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. Nature Genetics, 45(1), 67-71. https://doi.org/10.1038/ng.2494

Vancouver

Zhao S, Zheng P, Dong S, Zhan X, Wu Q, Guo X et al. Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. Nature Genetics. 2013;45(1):67-71. https://doi.org/10.1038/ng.2494

Author

Zhao, Shancen ; Zheng, Pingping ; Dong, Shanshan ; Zhan, Xiangjiang ; Wu, Qi ; Guo, Xiaosen ; Hu, Yibo ; He, Weiming ; Zhang, Shanning ; Fan, Wei ; Zhu, Lifeng ; Li, Dong ; Zhang, Xuemei ; Chen, Quan ; Zhang, Hemin ; Zhang, Zhihe ; Jin, Xuelin ; Zhang, Jinguo ; Yang, Huanming ; Wang, Jian ; Wang, Jun ; Wei, Fuwen. / Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation. In: Nature Genetics. 2013 ; Vol. 45, No. 1. pp. 67-71.

Bibtex

@article{a7083796db88448aa4de35b77fcf137f,
title = "Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation",
abstract = "The panda lineage dates back to the late Miocene and ultimately leads to only one extant species, the giant panda (Ailuropoda melanoleuca). Although global climate change and anthropogenic disturbances are recognized to shape animal population demography their contribution to panda population dynamics remains largely unknown. We sequenced the whole genomes of 34 pandas at an average 4.7-fold coverage and used this data set together with the previously deep-sequenced panda genome to reconstruct a continuous demographic history of pandas from their origin to the present. We identify two population expansions, two bottlenecks and two divergences. Evidence indicated that, whereas global changes in climate were the primary drivers of population fluctuation for millions of years, human activities likely underlie recent population divergence and serious decline. We identified three distinct panda populations that show genetic adaptation to their environments. However, in all three populations, anthropogenic activities have negatively affected pandas for 3,000 years.",
author = "Shancen Zhao and Pingping Zheng and Shanshan Dong and Xiangjiang Zhan and Qi Wu and Xiaosen Guo and Yibo Hu and Weiming He and Shanning Zhang and Wei Fan and Lifeng Zhu and Dong Li and Xuemei Zhang and Quan Chen and Hemin Zhang and Zhihe Zhang and Xuelin Jin and Jinguo Zhang and Huanming Yang and Jian Wang and Jun Wang and Fuwen Wei",
year = "2013",
doi = "10.1038/ng.2494",
language = "English",
volume = "45",
pages = "67--71",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation

AU - Zhao, Shancen

AU - Zheng, Pingping

AU - Dong, Shanshan

AU - Zhan, Xiangjiang

AU - Wu, Qi

AU - Guo, Xiaosen

AU - Hu, Yibo

AU - He, Weiming

AU - Zhang, Shanning

AU - Fan, Wei

AU - Zhu, Lifeng

AU - Li, Dong

AU - Zhang, Xuemei

AU - Chen, Quan

AU - Zhang, Hemin

AU - Zhang, Zhihe

AU - Jin, Xuelin

AU - Zhang, Jinguo

AU - Yang, Huanming

AU - Wang, Jian

AU - Wang, Jun

AU - Wei, Fuwen

PY - 2013

Y1 - 2013

N2 - The panda lineage dates back to the late Miocene and ultimately leads to only one extant species, the giant panda (Ailuropoda melanoleuca). Although global climate change and anthropogenic disturbances are recognized to shape animal population demography their contribution to panda population dynamics remains largely unknown. We sequenced the whole genomes of 34 pandas at an average 4.7-fold coverage and used this data set together with the previously deep-sequenced panda genome to reconstruct a continuous demographic history of pandas from their origin to the present. We identify two population expansions, two bottlenecks and two divergences. Evidence indicated that, whereas global changes in climate were the primary drivers of population fluctuation for millions of years, human activities likely underlie recent population divergence and serious decline. We identified three distinct panda populations that show genetic adaptation to their environments. However, in all three populations, anthropogenic activities have negatively affected pandas for 3,000 years.

AB - The panda lineage dates back to the late Miocene and ultimately leads to only one extant species, the giant panda (Ailuropoda melanoleuca). Although global climate change and anthropogenic disturbances are recognized to shape animal population demography their contribution to panda population dynamics remains largely unknown. We sequenced the whole genomes of 34 pandas at an average 4.7-fold coverage and used this data set together with the previously deep-sequenced panda genome to reconstruct a continuous demographic history of pandas from their origin to the present. We identify two population expansions, two bottlenecks and two divergences. Evidence indicated that, whereas global changes in climate were the primary drivers of population fluctuation for millions of years, human activities likely underlie recent population divergence and serious decline. We identified three distinct panda populations that show genetic adaptation to their environments. However, in all three populations, anthropogenic activities have negatively affected pandas for 3,000 years.

U2 - 10.1038/ng.2494

DO - 10.1038/ng.2494

M3 - Letter

C2 - 23242367

VL - 45

SP - 67

EP - 71

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 1

ER -

ID: 46094290