Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response

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Standard

Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response. / Tu, Kimberly C.; Long, Tao; Svenningsen, Sine Lo; Wingreen, Ned S.; Bassler, Bonnie L.

I: Molecular Cell, Bind 37, Nr. 4, 26.02.2010, s. 567-579.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tu, KC, Long, T, Svenningsen, SL, Wingreen, NS & Bassler, BL 2010, 'Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response', Molecular Cell, bind 37, nr. 4, s. 567-579. https://doi.org/10.1016/j.molcel.2010.01.022

APA

Tu, K. C., Long, T., Svenningsen, S. L., Wingreen, N. S., & Bassler, B. L. (2010). Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response. Molecular Cell, 37(4), 567-579. https://doi.org/10.1016/j.molcel.2010.01.022

Vancouver

Tu KC, Long T, Svenningsen SL, Wingreen NS, Bassler BL. Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response. Molecular Cell. 2010 feb. 26;37(4):567-579. https://doi.org/10.1016/j.molcel.2010.01.022

Author

Tu, Kimberly C. ; Long, Tao ; Svenningsen, Sine Lo ; Wingreen, Ned S. ; Bassler, Bonnie L. / Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response. I: Molecular Cell. 2010 ; Bind 37, Nr. 4. s. 567-579.

Bibtex

@article{79191db03892479a825fd53e7155b9e9,
title = "Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response",
abstract = "Quorum sensing (QS) bacteria assess population density through secretion and detection of molecules called autoinducers (AIs). We identify and characterize two Vibrio harveyi negative feedback loops that facilitate precise transitions between low-cell-density (LCD) and high-cell-density (HCD) states. The QS central regulator LuxO autorepresses its own transcription and the Qrr small regulatory RNAs (sRNAs) posttranscriptionally repress luxO. Disrupting feedback increases the concentration of AIs required for cells to transit from LCD to HCD QS modes. Thus, the two cooperative negative feedback loops determine the point at which V. harveyi has reached a quorum and control the range of AIs over which the transition occurs. Negative feedback regulation also constrains the range of QS output – by preventing sRNA levels from becoming too high and preventing luxO mRNA levels from reaching zero. We suggest that sRNA-mediated feedback regulation is a network design feature that permits fine-tuning of gene regulation and maintenance of homeostasis.",
author = "Tu, {Kimberly C.} and Tao Long and Svenningsen, {Sine Lo} and Wingreen, {Ned S.} and Bassler, {Bonnie L.}",
year = "2010",
month = feb,
day = "26",
doi = "10.1016/j.molcel.2010.01.022",
language = "English",
volume = "37",
pages = "567--579",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi qourum-sensing response

AU - Tu, Kimberly C.

AU - Long, Tao

AU - Svenningsen, Sine Lo

AU - Wingreen, Ned S.

AU - Bassler, Bonnie L.

PY - 2010/2/26

Y1 - 2010/2/26

N2 - Quorum sensing (QS) bacteria assess population density through secretion and detection of molecules called autoinducers (AIs). We identify and characterize two Vibrio harveyi negative feedback loops that facilitate precise transitions between low-cell-density (LCD) and high-cell-density (HCD) states. The QS central regulator LuxO autorepresses its own transcription and the Qrr small regulatory RNAs (sRNAs) posttranscriptionally repress luxO. Disrupting feedback increases the concentration of AIs required for cells to transit from LCD to HCD QS modes. Thus, the two cooperative negative feedback loops determine the point at which V. harveyi has reached a quorum and control the range of AIs over which the transition occurs. Negative feedback regulation also constrains the range of QS output – by preventing sRNA levels from becoming too high and preventing luxO mRNA levels from reaching zero. We suggest that sRNA-mediated feedback regulation is a network design feature that permits fine-tuning of gene regulation and maintenance of homeostasis.

AB - Quorum sensing (QS) bacteria assess population density through secretion and detection of molecules called autoinducers (AIs). We identify and characterize two Vibrio harveyi negative feedback loops that facilitate precise transitions between low-cell-density (LCD) and high-cell-density (HCD) states. The QS central regulator LuxO autorepresses its own transcription and the Qrr small regulatory RNAs (sRNAs) posttranscriptionally repress luxO. Disrupting feedback increases the concentration of AIs required for cells to transit from LCD to HCD QS modes. Thus, the two cooperative negative feedback loops determine the point at which V. harveyi has reached a quorum and control the range of AIs over which the transition occurs. Negative feedback regulation also constrains the range of QS output – by preventing sRNA levels from becoming too high and preventing luxO mRNA levels from reaching zero. We suggest that sRNA-mediated feedback regulation is a network design feature that permits fine-tuning of gene regulation and maintenance of homeostasis.

U2 - 10.1016/j.molcel.2010.01.022

DO - 10.1016/j.molcel.2010.01.022

M3 - Journal article

C2 - 20188674

VL - 37

SP - 567

EP - 579

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 4

ER -

ID: 33762437