Lone Rønnov-Jessen

Lone Rønnov-Jessen

Associate Professor


  1. 2024
  2. Published

    Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer

    Bagger, M. M., Sjölund, J., Kim, Jiyoung, Kohler, Katharina Theresa, Villadsen, René, Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Pietras, K., Rønnov-Jessen, Lone & Petersen, Ole William, 2024, In: Breast Cancer Research. 26, 1, 19 p., 11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2022
  4. Published

    Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

    Kohler, Katharina Theresa, Goldhammer, N., Demharter, S., Pfisterer, U., Khodosevich, Konstantin, Rønnov-Jessen, Lone, Petersen, Ole William, Villadsen, René & Kim, Jiyoung, 2022, In: npj Breast Cancer. 8, 1, 12 p., 81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation

    Goldhammer, N., Kim, Jiyoung, Villadsen, René, Rønnov-Jessen, Lone & Petersen, Ole William, 2022, In: Communications Biology . 5, 1, 13 p., 219.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2021
  7. Published

    Desensitization of human breast progenitors by a transient exposure to pregnancy levels of estrogen

    Rønnov-Jessen, Lone, Kim, Jiyoung, Goldhammer, N., Klitgaard, M. C., Smicius, M., Bechmann, M. B., Villadsen, René & Petersen, Ole William, 2021, In: Scientific Reports. 11, 7 p., 17232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2020
  9. Published

    Fibroblasts direct differentiation of human breast epithelial progenitors

    Morsing, M., Kim, Jiyoung, Villadsen, René, Goldhammer, N., Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Petersen, Ole William & Rønnov-Jessen, Lone, 2020, In: Breast Cancer Research. 22, 16 p., 102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2019
  11. Published

    A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors

    Ísberg, Ó. G., Kim, Jiyoung, Fridriksdottir, A. J., Morsing, M., Timmermans-Wielenga, V., Rønnov-Jessen, Lone, Petersen, Ole William & Villadsen, René, 2019, In: Scientific Reports. 9, 11 p., 14843.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2018
  13. Published

    Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity

    Bagger, Sofie Morsing, Hopkinson, B. M., Pandey, D. P., Bak, M., Brydholm, A. V., Villadsen, René, Helin, K., Rønnov-Jessen, Lone, Petersen, Ole William & Kim, Jiyoung, 2018, In: Molecular Cancer. 17, 1, p. 1-6 6 p., 171.

    Research output: Contribution to journalComment/debateResearchpeer-review

  14. 2017
  15. Published

    Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype

    Hopkinson, B. M., Klitgaard, M. C., Petersen, Ole William, Villadsen, René, Rønnov-Jessen, Lone & Kim, Jiyoung, 7 Feb 2017, In: OncoTarget. 8, 6, p. 10580-10593 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Proof of region-specific multipotent progenitors in human breast epithelia

    Fridriksdottir, A. J., Villadsen, René, Morsing, M., Klitgaard, M. C., Kim, Jiyoung, Petersen, Ole William & Rønnov-Jessen, Lone, 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. E10102–E10111

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2016
  18. Published

    Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

    Morsing, M., Klitgaard, M. C., Jafari Kermani, Abbas, Villadsen, René, Kassem, Moustapha Saad El-Deen, Petersen, Ole William & Rønnov-Jessen, Lone, 2016, In: Breast Cancer Research (Online). 18, 11 p., 108.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2015
  20. Published

    Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture

    Fridriksdóttir, A. J. R., Kim, Jiyoung, Villadsen, René, Klitgaard, M. C., Hopkinson, B. M., Petersen, Ole William & Rønnov-Jessen, Lone, 2015, In: Nature Communications. 6, 12 p., 8786.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2012
  22. Published

    The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

    Lauritzen, G., Stock, C., Lemaire, J., Lund, S. F., Jensen, M. F., Damsgaard, B., Petersen, K. S., Wiwel, M., Rønnov-Jessen, Lone, Schwab, A. & Pedersen, Stine Helene Falsig, 2012, In: Cancer Letters. 317, 2, p. 172-183 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity

    Kim, Jiyoung, Villadsen, René, Sørlie, T., Fogh, L., Grønlund, S. Z., Fridriksdóttir, A. J. R., Kuhn, I., Rank, F., Wielenga, V. T., Solvang, H., Edwards, P. A. W., Børresen-Dale, A., Rønnov-Jessen, Lone, Bissell, M. J. & Petersen, Ole William, 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6124-6129 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2011
  25. Published

    Mammary gland stem cells: current status and future challenges

    Fridriksdottir, A. J. R., Petersen, Ole William & Rønnov-Jessen, Lone, 2011, In: International Journal of Developmental Biology. 55, 7-9, p. 719-29 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2010
  27. Published

    Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment

    De Neergaard, M., Kim, Jiyoung, Villadsen, René, Fridriksdóttir, A. J. R., Rank, F., Timmermans-Wielenga, V., Langerød, A., Børresen-Dale, A., Petersen, Ole William & Rønnov-Jessen, Lone, 2010, In: American Journal of Pathology. 176, 3, p. 1229-1240 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2009
  29. Published

    Breast cancer by proxy: can the microenvironment be both the cause and consequence?

    Rønnov-Jessen, Lone & Bissell, M. J., 2009, In: Trends in Molecular Medicine. 15, 1, p. 5-13 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2008
  31. Published

    Dissection of a stem cell hierarchy in the human breast

    Rubner Fridriksdottir, A. J., Villadsen, René, Kim, Jiyoung, Rønnov-Jessen, Lone & Petersen, Ole William, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. p. 412 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  32. Published

    Expression, regulation and function of epithelial-stromal interaction 1 (breast), EPSTI1

    Villadsen, R., Lind Nielsen, H., Rank, F., Petersen, O. W., Rønnov-Jessen, Lone & Neergaard, M. D., 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 5, p. 430-431 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  33. 2007
  34. Published

    Evidence for a stem cell hierarchy in the adult human breast

    Villadsen, René, Fridriksdottir, A. J., Rønnov-Jessen, Lone, Gudjonsson, T., Rank, F., LaBarge, M. A., Bissell, M. J. & Petersen, Ole William, 2007, In: Journal of Cell Biology. 177, 1, p. 87-101 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2004
  36. Published

    Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression

    Nielsen, H. L., Gudjonsson, T., Villadsen, René, Rønnov-Jessen, Lone & Petersen, Ole William, 2004, In: In Vitro Cellular & Developmental Biology - Animal. 39, 7, p. 297-303 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Immortalization protocols used in cell culture models of human breast morphogenesis

    Gudjonsson, T., Villadsen, René, Rønnov-Jessen, Lone & Petersen, O. W., 2004, In: Cellular and molecular life sciences : CMLS. 61, 19-20, p. 2523-34 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2003
  39. Published

    Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia

    Petersen, Ole William, Gudjonsson, T., Villadsen, René, Bissell, M. J. & Rønnov-Jessen, Lone, 2003, In: Cell Proliferation. 36 Suppl 1, p. 33-44 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Epithelial to Mesenchymal Transition in Human Breast Cancer Can Provide a Nonmalignant Stroma

    Petersen, Ole William, Nielsen, H. L., Gudjonsson, T., Villadsen, René, Rank, F. E., Niebuhr, E., Bisell, M. J. & Rønnov-Jessen, Lone, 2003, In: American Journal og Pathology. Vol. 162, p. 391-402

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Stamceller

    Rønnov-Jessen, Lone & Petersen, Ole William, 2003, In: Naturens Verden. Vol. 86, p. 24-29

    Research output: Contribution to journalJournal articleResearch

  42. Published

    To create the correct microenvironment: Three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia

    Gudjonsson, T., Rønnov-Jessen, Lone, Villadsen, René, Bissell, M. J. & Petersen, Ole William, 2003, In: Methods. Vol. 30, p. 247-255

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2002
  44. Published

    Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-β1-mediated conversion of fibroblasts to myofibroblasts

    Rønnov-Jessen, Lone, Villadsen, René, Edwards, J. C. & Petersen, Ole William, 2002, In: American Journal of Pathology. 161, 2, p. 471-480 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer

    Nielsen, H. L., Rønnov-Jessen, Lone, Villadsen, René & Petersen, Ole William, 2002, In: Genomics. 79, 5, p. 703-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties

    Gudjonsson, T., Villadsen, René, Nielsen, H. L., Rønnov-Jessen, Lone, Bissell, M. J. & Petersen, Ole William, 2002, In: Genes Dev. vol. 16(6), p. 693-706

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

    Gudjonsson, T., Rønnov-Jessen, Lone, Villadsen, René, Rank, F. E., Bissell, M. J. & Petersen, Ole William, 2002, In: Journal of Cell Science. 115, p. 39-50

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2001
  49. Published

    The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion

    Petersen, Ole William, Nielsen, H. L., Gudjonsson, T., Villadsen, René, Rønnov-Jessen, Lone & Bissell, M. J., 2001, In: Breast Cancer Research (Online Edition). 3, p. 213-217

    Research output: Contribution to journalReviewResearch

  50. 1999
  51. Published

    Human mammary luminal cells contain progenitors to myoepithelial cells.

    Péchoux, C., Gudjonsson, T., Rønnov-Jessen, Lone, Bissell, M. J. & Petersen, O. W., 1999, In: Dev. Biol.. 206, p. 88-99

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 1998
  53. Published

    Differentiation and cancer in the mammary gland: shedding light on an old dichotomy

    Petersen, Ole William, Rønnov-Jessen, Lone, Weaver, V. M. & Bissell, M. J., 1998, In: Advances in Cancer Research. 75, p. 135-61 26 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 1996
  55. Published

    A function for filamentous alpha-smooth muscle actin: Retardation of motility in human breast fibroblasts

    Rønnov-Jessen, Lone & Petersen, Ole William, 1996, In: Journal of Cell Biology. 134, 1, p. 67-80

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    ADP-ribosylation of actins in fibroblasts and myofibroblasts by botulinum C2 toxin: Influence on microfilament morphology and migratory behavior

    Rønnov-Jessen, Lone & Petersen, Ole William, 1996, In: Electrophoresis. 17, 11, p. 1776-1780

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Cellular changes involved in conversion of normal to malignant breast: The importance of the stromal reaction

    Rønnov-Jessen, Lone, Petersen, Ole William & Bissell, M. J., 1996, In: Physiological Reviews. 76, p. 69-125

    Research output: Contribution to journalReviewResearch

  58. Published

    Stromal reaction to invasive cancer: The cellular origin of the myofibroblast and implications for tumor development

    Rønnov-Jessen, Lone, 1996, In: Breast Journal. 2, p. 320-339

    Research output: Contribution to journalReviewResearch

  59. 1995
  60. Published
  61. Published

    The origin of myofibroblasts in breast cancer: Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells in conversion

    Rønnov-Jessen, Lone, Petersen, Ole William, Koteliansky, V. & Bissell, M. J., 1995, In: Journal of Clinical Investigation. 95, p. 859-873

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. 1993
  63. Published

    Effects of lymphocytes and fibroblasts on the growth of human mammary carcinoma cells studied in short-term primary cultures

    Ögmundsdöttir, H. M., Pétursdöttir, I., Gudmundsdöttir, I., Amundadöttir, L., Rønnov-Jessen, Lone & Petersen, O. W., 1993, In: In Vitro Cell Dev Biology. Vol 29A, p. 936-942

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published
  65. 1992
  66. Published

    A fibroblast-associated antigen: Characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells

    Rønnov-Jessen, Lone, Celis, J. E., van Deurs, B. & Petersen, Ole William, 1992, In: Journal of Histochemistry and Cytochemistry. 40, 4, p. 475-486

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Identification, paracrine generation and possible function of human breast carcinoma myofibroblasts in culture

    Rønnov-Jessen, Lone, van Deurs, B., Nielsen, M. & Petersen, Ole William, 1992, In: In Vitro Cellular & Developmental Biology - Animal. 28A, p. 273-283

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant breast epithelial cells

    Petersen, Ole William, Rønnov-Jessen, Lone, Howlett, A. & Bissell, M. J., 1992, In: Proceedings of the National Academy of Science of the United States of America. 89, p. 9064-9068

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. 1991
  70. Published
  71. 1990
  72. Published
  73. Published

    Smooth muscle differentiation in cultured human breast gland stromal cells

    Rønnov-Jessen, Lone, van Deurs, B., Celis, J. E. & Petersen, Ole William, 1990, In: Laboratory Investigation. 63, 4, p. 532-543

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4950