A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases

Research output: Contribution to journalJournal articlepeer-review

Standard

A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases. / Liu, Xiaomin; Tang, Shanmei; Zhong, Huanzi; Tong, Xin; Jie, Zhuye; Ding, Qiuxia; Wang, Dan; Guo, Ruidong; Xiao, Liang; Xu, Xun; Yang, Huanming; Wang, Jian; Zong, Yang; Liu, Weibin; Liu, Xiao; Zhang, Yong; Brix, Susanne; Kristiansen, Karsten; Hou, Yong; Jia, Huijue; Zhang, Tao.

In: Cell Discovery, Vol. 7, 9, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Liu, X, Tang, S, Zhong, H, Tong, X, Jie, Z, Ding, Q, Wang, D, Guo, R, Xiao, L, Xu, X, Yang, H, Wang, J, Zong, Y, Liu, W, Liu, X, Zhang, Y, Brix, S, Kristiansen, K, Hou, Y, Jia, H & Zhang, T 2021, 'A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases', Cell Discovery, vol. 7, 9. https://doi.org/10.1038/s41421-020-00239-w

APA

Liu, X., Tang, S., Zhong, H., Tong, X., Jie, Z., Ding, Q., Wang, D., Guo, R., Xiao, L., Xu, X., Yang, H., Wang, J., Zong, Y., Liu, W., Liu, X., Zhang, Y., Brix, S., Kristiansen, K., Hou, Y., ... Zhang, T. (2021). A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases. Cell Discovery, 7, [9]. https://doi.org/10.1038/s41421-020-00239-w

Vancouver

Liu X, Tang S, Zhong H, Tong X, Jie Z, Ding Q et al. A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases. Cell Discovery. 2021;7. 9. https://doi.org/10.1038/s41421-020-00239-w

Author

Liu, Xiaomin ; Tang, Shanmei ; Zhong, Huanzi ; Tong, Xin ; Jie, Zhuye ; Ding, Qiuxia ; Wang, Dan ; Guo, Ruidong ; Xiao, Liang ; Xu, Xun ; Yang, Huanming ; Wang, Jian ; Zong, Yang ; Liu, Weibin ; Liu, Xiao ; Zhang, Yong ; Brix, Susanne ; Kristiansen, Karsten ; Hou, Yong ; Jia, Huijue ; Zhang, Tao. / A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases. In: Cell Discovery. 2021 ; Vol. 7.

Bibtex

@article{991a210e0d3d4366a0c5c9c438e0fa32,
title = "A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases",
abstract = "The gut microbiome has been established as a key environmental factor to health. Genetic influences on the gut microbiome have been reported, yet, doubts remain as to the significance of genetic associations. Here, we provide shotgun data for whole genome and whole metagenome from a Chinese cohort, identifying no <20% genetic contribution to the gut microbiota. Using common variants-, rare variants-, and copy number variations-based association analyses, we identified abundant signals associated with the gut microbiome especially in metabolic, neurological, and immunological functions. The controversial concept of enterotypes may have a genetic attribute, with the top two loci explaining 11% of the Prevotella–Bacteroides variances. Stratification according to gender led to the identification of differential associations in males and females. Our two-stage metagenome genome-wide association studies on a total of 1295 individuals unequivocally illustrates that neither microbiome nor GWAS studies could overlook one another in our quest for a better understanding of human health and diseases.",
author = "Xiaomin Liu and Shanmei Tang and Huanzi Zhong and Xin Tong and Zhuye Jie and Qiuxia Ding and Dan Wang and Ruidong Guo and Liang Xiao and Xun Xu and Huanming Yang and Jian Wang and Yang Zong and Weibin Liu and Xiao Liu and Yong Zhang and Susanne Brix and Karsten Kristiansen and Yong Hou and Huijue Jia and Tao Zhang",
year = "2021",
doi = "10.1038/s41421-020-00239-w",
language = "English",
volume = "7",
journal = "Cell Discovery",
issn = "2056-5968",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases

AU - Liu, Xiaomin

AU - Tang, Shanmei

AU - Zhong, Huanzi

AU - Tong, Xin

AU - Jie, Zhuye

AU - Ding, Qiuxia

AU - Wang, Dan

AU - Guo, Ruidong

AU - Xiao, Liang

AU - Xu, Xun

AU - Yang, Huanming

AU - Wang, Jian

AU - Zong, Yang

AU - Liu, Weibin

AU - Liu, Xiao

AU - Zhang, Yong

AU - Brix, Susanne

AU - Kristiansen, Karsten

AU - Hou, Yong

AU - Jia, Huijue

AU - Zhang, Tao

PY - 2021

Y1 - 2021

N2 - The gut microbiome has been established as a key environmental factor to health. Genetic influences on the gut microbiome have been reported, yet, doubts remain as to the significance of genetic associations. Here, we provide shotgun data for whole genome and whole metagenome from a Chinese cohort, identifying no <20% genetic contribution to the gut microbiota. Using common variants-, rare variants-, and copy number variations-based association analyses, we identified abundant signals associated with the gut microbiome especially in metabolic, neurological, and immunological functions. The controversial concept of enterotypes may have a genetic attribute, with the top two loci explaining 11% of the Prevotella–Bacteroides variances. Stratification according to gender led to the identification of differential associations in males and females. Our two-stage metagenome genome-wide association studies on a total of 1295 individuals unequivocally illustrates that neither microbiome nor GWAS studies could overlook one another in our quest for a better understanding of human health and diseases.

AB - The gut microbiome has been established as a key environmental factor to health. Genetic influences on the gut microbiome have been reported, yet, doubts remain as to the significance of genetic associations. Here, we provide shotgun data for whole genome and whole metagenome from a Chinese cohort, identifying no <20% genetic contribution to the gut microbiota. Using common variants-, rare variants-, and copy number variations-based association analyses, we identified abundant signals associated with the gut microbiome especially in metabolic, neurological, and immunological functions. The controversial concept of enterotypes may have a genetic attribute, with the top two loci explaining 11% of the Prevotella–Bacteroides variances. Stratification according to gender led to the identification of differential associations in males and females. Our two-stage metagenome genome-wide association studies on a total of 1295 individuals unequivocally illustrates that neither microbiome nor GWAS studies could overlook one another in our quest for a better understanding of human health and diseases.

U2 - 10.1038/s41421-020-00239-w

DO - 10.1038/s41421-020-00239-w

M3 - Journal article

C2 - 33563976

AN - SCOPUS:85100782799

VL - 7

JO - Cell Discovery

JF - Cell Discovery

SN - 2056-5968

M1 - 9

ER -

ID: 257540034