Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
Research output: Contribution to journal › Review › Research › peer-review
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.
Original language | English |
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Journal | Nature Methods |
Volume | 17 |
Issue number | 5 |
Pages (from-to) | 471-479 |
Number of pages | 9 |
ISSN | 1548-7091 |
DOIs | |
Publication status | Published - 2020 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510557/pdf/nihms-1679494.pdf
Accepted author manuscript
ID: 239855966