Cervicovaginal microbiome dynamics after taking oral probiotics

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cervicovaginal microbiome dynamics after taking oral probiotics. / Chen, Chen; Hao, Lilan; Zhang, Zhe; Tian, Liu; Zhang, Xiaowei; Zhu, Jie; Jie, Zhuye; Tong, Xin; Xiao, Liang; Zhang, Tao; Jin, Xin; Xu, Xun; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Jia, Huijue.

In: Journal of Genetics and Genomics, Vol. 48, No. 8, 2021, p. 716-726.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chen, C, Hao, L, Zhang, Z, Tian, L, Zhang, X, Zhu, J, Jie, Z, Tong, X, Xiao, L, Zhang, T, Jin, X, Xu, X, Yang, H, Wang, J, Kristiansen, K & Jia, H 2021, 'Cervicovaginal microbiome dynamics after taking oral probiotics', Journal of Genetics and Genomics, vol. 48, no. 8, pp. 716-726. https://doi.org/10.1016/j.jgg.2021.03.019

APA

Chen, C., Hao, L., Zhang, Z., Tian, L., Zhang, X., Zhu, J., Jie, Z., Tong, X., Xiao, L., Zhang, T., Jin, X., Xu, X., Yang, H., Wang, J., Kristiansen, K., & Jia, H. (2021). Cervicovaginal microbiome dynamics after taking oral probiotics. Journal of Genetics and Genomics, 48(8), 716-726. https://doi.org/10.1016/j.jgg.2021.03.019

Vancouver

Chen C, Hao L, Zhang Z, Tian L, Zhang X, Zhu J et al. Cervicovaginal microbiome dynamics after taking oral probiotics. Journal of Genetics and Genomics. 2021;48(8):716-726. https://doi.org/10.1016/j.jgg.2021.03.019

Author

Chen, Chen ; Hao, Lilan ; Zhang, Zhe ; Tian, Liu ; Zhang, Xiaowei ; Zhu, Jie ; Jie, Zhuye ; Tong, Xin ; Xiao, Liang ; Zhang, Tao ; Jin, Xin ; Xu, Xun ; Yang, Huanming ; Wang, Jian ; Kristiansen, Karsten ; Jia, Huijue. / Cervicovaginal microbiome dynamics after taking oral probiotics. In: Journal of Genetics and Genomics. 2021 ; Vol. 48, No. 8. pp. 716-726.

Bibtex

@article{0e0fe645c74c42aab8eec353e069bbae,

title = "Cervicovaginal microbiome dynamics after taking oral probiotics",

abstract = "The vaginal microbiota is less complex than the gut microbiota, and the colonization of Lactobacillus in the female vagina is considered to be critical for reproductive health. Oral probiotics have been suggested as promising means to modulate vaginal homeostasis in the general population. In this study, 60 Chinese women were followed for over a year before, during, and after treatment with the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support a colonization route of the probiotics from the oral cavity to the intestinal tract and then to the vagina. Our analyses enable the classification of the cervicovaginal microbiome into a stable state and a state of dysbiosis. The microbiome in the stable group steadily maintained a relatively high abundance of Lactobacilli over 1 year, which was not affected by probiotic intake, whereas in the dysbiosis group, the microbiota was more diverse and changed markedly over time. Data from a subset of the dysbiosis group suggests this subgroup possibly benefited from supplementation with the probiotics, indicating that probiotics supplementation can be prescribed for women in a subclinical microbiome setting of dysbiosis, providing opportunities for targeted and personalized microbiome reconstitution.",

keywords = "Cervicovaginal microbiome, Oral probiotics, Shotgun metagenomic data",

author = "Chen Chen and Lilan Hao and Zhe Zhang and Liu Tian and Xiaowei Zhang and Jie Zhu and Zhuye Jie and Xin Tong and Liang Xiao and Tao Zhang and Xin Jin and Xun Xu and Huanming Yang and Jian Wang and Karsten Kristiansen and Huijue Jia",

note = "Publisher Copyright: {\textcopyright} 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China",

year = "2021",

doi = "10.1016/j.jgg.2021.03.019",

language = "English",

volume = "48",

pages = "716--726",

journal = "Journal of Genetics and Genomics",

issn = "1673-8527",

publisher = "Elsevier",

number = "8",

}

RIS

TY - JOUR

T1 - Cervicovaginal microbiome dynamics after taking oral probiotics

AU - Chen, Chen

AU - Hao, Lilan

AU - Zhang, Zhe

AU - Tian, Liu

AU - Zhang, Xiaowei

AU - Zhu, Jie

AU - Jie, Zhuye

AU - Tong, Xin

AU - Xiao, Liang

AU - Zhang, Tao

AU - Jin, Xin

AU - Xu, Xun

AU - Yang, Huanming

AU - Wang, Jian

AU - Kristiansen, Karsten

AU - Jia, Huijue

PY - 2021

Y1 - 2021

N2 - The vaginal microbiota is less complex than the gut microbiota, and the colonization of Lactobacillus in the female vagina is considered to be critical for reproductive health. Oral probiotics have been suggested as promising means to modulate vaginal homeostasis in the general population. In this study, 60 Chinese women were followed for over a year before, during, and after treatment with the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support a colonization route of the probiotics from the oral cavity to the intestinal tract and then to the vagina. Our analyses enable the classification of the cervicovaginal microbiome into a stable state and a state of dysbiosis. The microbiome in the stable group steadily maintained a relatively high abundance of Lactobacilli over 1 year, which was not affected by probiotic intake, whereas in the dysbiosis group, the microbiota was more diverse and changed markedly over time. Data from a subset of the dysbiosis group suggests this subgroup possibly benefited from supplementation with the probiotics, indicating that probiotics supplementation can be prescribed for women in a subclinical microbiome setting of dysbiosis, providing opportunities for targeted and personalized microbiome reconstitution.

AB - The vaginal microbiota is less complex than the gut microbiota, and the colonization of Lactobacillus in the female vagina is considered to be critical for reproductive health. Oral probiotics have been suggested as promising means to modulate vaginal homeostasis in the general population. In this study, 60 Chinese women were followed for over a year before, during, and after treatment with the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support a colonization route of the probiotics from the oral cavity to the intestinal tract and then to the vagina. Our analyses enable the classification of the cervicovaginal microbiome into a stable state and a state of dysbiosis. The microbiome in the stable group steadily maintained a relatively high abundance of Lactobacilli over 1 year, which was not affected by probiotic intake, whereas in the dysbiosis group, the microbiota was more diverse and changed markedly over time. Data from a subset of the dysbiosis group suggests this subgroup possibly benefited from supplementation with the probiotics, indicating that probiotics supplementation can be prescribed for women in a subclinical microbiome setting of dysbiosis, providing opportunities for targeted and personalized microbiome reconstitution.

KW - Cervicovaginal microbiome

KW - Oral probiotics

KW - Shotgun metagenomic data

U2 - 10.1016/j.jgg.2021.03.019

DO - 10.1016/j.jgg.2021.03.019

M3 - Journal article

C2 - 34391676

AN - SCOPUS:85112421838

VL - 48

SP - 716

EP - 726

JO - Journal of Genetics and Genomics

JF - Journal of Genetics and Genomics

SN - 1673-8527

IS - 8

ER -

ID: 279133771

Department of Biology