Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

Research output: Contribution to journal › Journal article › Research › peer-review

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Developmental trajectory of the healthy human gut microbiota during the first 5 years of life. / Roswall, Josefine; Olsson, Lisa M.; Kovatcheva-Datchary, Petia; Nilsson, Staffan; Tremaroli, Valentina; Simon, Marie-Christine; Kiilerich, Pia; Akrami, Rozita; Kramer, Manuela; Uhlen, Mathias; Gummesson, Anders; Kristiansen, Karsten; Dahlgren, Jovanna; Bäckhed, Fredrik.

In: Cell Host & Microbe, Vol. 29, No. 5, 2021, p. 765-776.e3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Roswall, J, Olsson, LM, Kovatcheva-Datchary, P, Nilsson, S, Tremaroli, V, Simon, M-C, Kiilerich, P, Akrami, R, Kramer, M, Uhlen, M, Gummesson, A, Kristiansen, K, Dahlgren, J & Bäckhed, F 2021, 'Developmental trajectory of the healthy human gut microbiota during the first 5 years of life', Cell Host & Microbe, vol. 29, no. 5, pp. 765-776.e3. https://doi.org/10.1016/j.chom.2021.02.021

APA

Roswall, J., Olsson, L. M., Kovatcheva-Datchary, P., Nilsson, S., Tremaroli, V., Simon, M-C., Kiilerich, P., Akrami, R., Kramer, M., Uhlen, M., Gummesson, A., Kristiansen, K., Dahlgren, J., & Bäckhed, F. (2021). Developmental trajectory of the healthy human gut microbiota during the first 5 years of life. Cell Host & Microbe, 29(5), 765-776.e3. https://doi.org/10.1016/j.chom.2021.02.021

Vancouver

Roswall J, Olsson LM, Kovatcheva-Datchary P, Nilsson S, Tremaroli V, Simon M-C et al. Developmental trajectory of the healthy human gut microbiota during the first 5 years of life. Cell Host & Microbe. 2021;29(5):765-776.e3. https://doi.org/10.1016/j.chom.2021.02.021

Author

Roswall, Josefine ; Olsson, Lisa M. ; Kovatcheva-Datchary, Petia ; Nilsson, Staffan ; Tremaroli, Valentina ; Simon, Marie-Christine ; Kiilerich, Pia ; Akrami, Rozita ; Kramer, Manuela ; Uhlen, Mathias ; Gummesson, Anders ; Kristiansen, Karsten ; Dahlgren, Jovanna ; Bäckhed, Fredrik. / Developmental trajectory of the healthy human gut microbiota during the first 5 years of life. In: Cell Host & Microbe. 2021 ; Vol. 29, No. 5. pp. 765-776.e3.

Bibtex

@article{56220435b7644d9599c1f7b373780ee4,
title = "Developmental trajectory of the healthy human gut microbiota during the first 5 years of life",
abstract = "The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.",
keywords = "INTESTINAL MICROBIOTA, REFERENCE VALUES, AGE, WEIGHT, BIRTH, OBESITY, TRANSMISSION, SEQUENCES, COMMUNITY, INFANTS",
author = "Josefine Roswall and Olsson, {Lisa M.} and Petia Kovatcheva-Datchary and Staffan Nilsson and Valentina Tremaroli and Marie-Christine Simon and Pia Kiilerich and Rozita Akrami and Manuela Kramer and Mathias Uhlen and Anders Gummesson and Karsten Kristiansen and Jovanna Dahlgren and Fredrik B{\"a}ckhed",
year = "2021",
doi = "10.1016/j.chom.2021.02.021",
language = "English",
volume = "29",
pages = "765--776.e3",
journal = "Cell Host & Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

AU - Roswall, Josefine

AU - Olsson, Lisa M.

AU - Kovatcheva-Datchary, Petia

AU - Nilsson, Staffan

AU - Tremaroli, Valentina

AU - Simon, Marie-Christine

AU - Kiilerich, Pia

AU - Akrami, Rozita

AU - Kramer, Manuela

AU - Uhlen, Mathias

AU - Gummesson, Anders

AU - Kristiansen, Karsten

AU - Dahlgren, Jovanna

AU - Bäckhed, Fredrik

PY - 2021

Y1 - 2021

N2 - The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.

AB - The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria are incorporated into the gut microbiota is still relatively unknown. Here, we analyze the microbiota from 471 Swedish children followed from birth to 5 years of age, collecting samples after 4 and 12 months and at 3 and 5 years of age as well as from their mothers at birth using 16S rRNA gene profiling. We also compare their microbiota to an adult Swedish population. Genera follow 4 different colonization patterns during establishment where Methanobrevibacter and Christensenellaceae colonize late and do not reached adult levels at 5 years. These late colonizers correlate with increased alpha diversity in both children and adults. By following the children through age-specific community types, we observe that children have individual dynamics in the gut microbiota development trajectory.

KW - INTESTINAL MICROBIOTA

KW - REFERENCE VALUES

KW - AGE

KW - WEIGHT

KW - BIRTH

KW - OBESITY

KW - TRANSMISSION

KW - SEQUENCES

KW - COMMUNITY

KW - INFANTS

U2 - 10.1016/j.chom.2021.02.021

DO - 10.1016/j.chom.2021.02.021

M3 - Journal article

C2 - 33794185

VL - 29

SP - 765-776.e3

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 5

ER -

ID: 272125856