Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites

Research output: Contribution to journalJournal articlepeer-review

Standard

Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites. / Jie, Zhuye; Liang, Suisha; Ding, Qiuxia; Li, Fei; Sun, Xiaohuan; Lin, Yuxiang; Chen, Peishan; Cai, Kaiye; Zhou, Hongcheng; Lu, Haorong; Wang, Xiaohan; Zhang, Tao; Xiao, Liang; Yang, Huanming; Wang, Jian; Hou, Yong; Kristiansen, Karsten; Jia, Huijue; Xu, Xun.

In: Medicine in Microecology, Vol. 9, 100037, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Jie, Z, Liang, S, Ding, Q, Li, F, Sun, X, Lin, Y, Chen, P, Cai, K, Zhou, H, Lu, H, Wang, X, Zhang, T, Xiao, L, Yang, H, Wang, J, Hou, Y, Kristiansen, K, Jia, H & Xu, X 2021, 'Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites', Medicine in Microecology, vol. 9, 100037. https://doi.org/10.1016/j.medmic.2021.100037

APA

Jie, Z., Liang, S., Ding, Q., Li, F., Sun, X., Lin, Y., Chen, P., Cai, K., Zhou, H., Lu, H., Wang, X., Zhang, T., Xiao, L., Yang, H., Wang, J., Hou, Y., Kristiansen, K., Jia, H., & Xu, X. (2021). Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites. Medicine in Microecology, 9, [100037]. https://doi.org/10.1016/j.medmic.2021.100037

Vancouver

Jie Z, Liang S, Ding Q, Li F, Sun X, Lin Y et al. Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites. Medicine in Microecology. 2021;9. 100037. https://doi.org/10.1016/j.medmic.2021.100037

Author

Jie, Zhuye ; Liang, Suisha ; Ding, Qiuxia ; Li, Fei ; Sun, Xiaohuan ; Lin, Yuxiang ; Chen, Peishan ; Cai, Kaiye ; Zhou, Hongcheng ; Lu, Haorong ; Wang, Xiaohan ; Zhang, Tao ; Xiao, Liang ; Yang, Huanming ; Wang, Jian ; Hou, Yong ; Kristiansen, Karsten ; Jia, Huijue ; Xu, Xun. / Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites. In: Medicine in Microecology. 2021 ; Vol. 9.

Bibtex

@article{bc92fa16a4c14a5898896e28899cb29b,
title = "Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites",
abstract = "Most of the disease studies for the gut microbiome have collected cases and control samples from the elderly or the middle-aged. Despite general interest in microbiome health, it is not known how microbial biomarkers from metagenome-wide association studies (MWAS) would perform in a cohort of young individuals, who would be largely free of chronic diseases, as well as medication. Here we analyze high-depth fecal metagenomic shotgun sequencing for 2183 healthy adults with clinical parameters, diet, lifestyle, and metabolite measurements. We provide the first set of large-scale evidence for gut microbiome dysbiosis in hyperuricemia, which relates to meat intake. We build a cardiometabolic disease risk model based on gut microbes for initial screening in a young population and confirm the validity using external cohorts. Fecal bacteria that have been reported to be enriched in colorectal cancer (CRC) are found to correlate with methylhistidines, branched-chain amino acids (BCAA), aromatic amino acids and glutamic acid in these young individuals, which were validated by an additional cohort of 1404 individuals. Our comprehensive data suggest that the gut microbiome could show trends towards diseases years before onset, and the results lay the foundation for the design of larger screens for cardiometabolic diseases and CRC with clinically meaningful cutoffs.",
keywords = "Disease, Gut microbiome, Multi-omic, Shotgun sequencing, Uric acid, Young individuals",
author = "Zhuye Jie and Suisha Liang and Qiuxia Ding and Fei Li and Xiaohuan Sun and Yuxiang Lin and Peishan Chen and Kaiye Cai and Hongcheng Zhou and Haorong Lu and Xiaohan Wang and Tao Zhang and Liang Xiao and Huanming Yang and Jian Wang and Yong Hou and Karsten Kristiansen and Huijue Jia and Xun Xu",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
doi = "10.1016/j.medmic.2021.100037",
language = "English",
volume = "9",
journal = "Medicine in Microecology",
issn = "2590-0978",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites

AU - Jie, Zhuye

AU - Liang, Suisha

AU - Ding, Qiuxia

AU - Li, Fei

AU - Sun, Xiaohuan

AU - Lin, Yuxiang

AU - Chen, Peishan

AU - Cai, Kaiye

AU - Zhou, Hongcheng

AU - Lu, Haorong

AU - Wang, Xiaohan

AU - Zhang, Tao

AU - Xiao, Liang

AU - Yang, Huanming

AU - Wang, Jian

AU - Hou, Yong

AU - Kristiansen, Karsten

AU - Jia, Huijue

AU - Xu, Xun

N1 - Publisher Copyright: © 2021 The Author(s)

PY - 2021

Y1 - 2021

N2 - Most of the disease studies for the gut microbiome have collected cases and control samples from the elderly or the middle-aged. Despite general interest in microbiome health, it is not known how microbial biomarkers from metagenome-wide association studies (MWAS) would perform in a cohort of young individuals, who would be largely free of chronic diseases, as well as medication. Here we analyze high-depth fecal metagenomic shotgun sequencing for 2183 healthy adults with clinical parameters, diet, lifestyle, and metabolite measurements. We provide the first set of large-scale evidence for gut microbiome dysbiosis in hyperuricemia, which relates to meat intake. We build a cardiometabolic disease risk model based on gut microbes for initial screening in a young population and confirm the validity using external cohorts. Fecal bacteria that have been reported to be enriched in colorectal cancer (CRC) are found to correlate with methylhistidines, branched-chain amino acids (BCAA), aromatic amino acids and glutamic acid in these young individuals, which were validated by an additional cohort of 1404 individuals. Our comprehensive data suggest that the gut microbiome could show trends towards diseases years before onset, and the results lay the foundation for the design of larger screens for cardiometabolic diseases and CRC with clinically meaningful cutoffs.

AB - Most of the disease studies for the gut microbiome have collected cases and control samples from the elderly or the middle-aged. Despite general interest in microbiome health, it is not known how microbial biomarkers from metagenome-wide association studies (MWAS) would perform in a cohort of young individuals, who would be largely free of chronic diseases, as well as medication. Here we analyze high-depth fecal metagenomic shotgun sequencing for 2183 healthy adults with clinical parameters, diet, lifestyle, and metabolite measurements. We provide the first set of large-scale evidence for gut microbiome dysbiosis in hyperuricemia, which relates to meat intake. We build a cardiometabolic disease risk model based on gut microbes for initial screening in a young population and confirm the validity using external cohorts. Fecal bacteria that have been reported to be enriched in colorectal cancer (CRC) are found to correlate with methylhistidines, branched-chain amino acids (BCAA), aromatic amino acids and glutamic acid in these young individuals, which were validated by an additional cohort of 1404 individuals. Our comprehensive data suggest that the gut microbiome could show trends towards diseases years before onset, and the results lay the foundation for the design of larger screens for cardiometabolic diseases and CRC with clinically meaningful cutoffs.

KW - Disease

KW - Gut microbiome

KW - Multi-omic

KW - Shotgun sequencing

KW - Uric acid

KW - Young individuals

U2 - 10.1016/j.medmic.2021.100037

DO - 10.1016/j.medmic.2021.100037

M3 - Journal article

AN - SCOPUS:85120612677

VL - 9

JO - Medicine in Microecology

JF - Medicine in Microecology

SN - 2590-0978

M1 - 100037

ER -

ID: 288656032