Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis

Research output: Contribution to journal › Review › Research › peer-review

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Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis. / von Eyben, Finn E.; Kristiansen, Karsten; Kapp, Daniel S.; Hu, Rong; Preda, Ovidiu; Nogales, Francisco F.

In: International Journal of Molecular Sciences, Vol. 24, No. 4, 4148, 2023.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

von Eyben, FE, Kristiansen, K, Kapp, DS, Hu, R, Preda, O & Nogales, FF 2023, 'Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis', International Journal of Molecular Sciences, vol. 24, no. 4, 4148. https://doi.org/10.3390/ijms24044148

APA

von Eyben, F. E., Kristiansen, K., Kapp, D. S., Hu, R., Preda, O., & Nogales, F. F. (2023). Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis. International Journal of Molecular Sciences, 24(4), [4148]. https://doi.org/10.3390/ijms24044148

Vancouver

von Eyben FE, Kristiansen K, Kapp DS, Hu R, Preda O, Nogales FF. Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis. International Journal of Molecular Sciences. 2023;24(4). 4148. https://doi.org/10.3390/ijms24044148

Author

von Eyben, Finn E. ; Kristiansen, Karsten ; Kapp, Daniel S. ; Hu, Rong ; Preda, Ovidiu ; Nogales, Francisco F. / Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis. In: International Journal of Molecular Sciences. 2023 ; Vol. 24, No. 4.

Bibtex

@article{3376141f36ec4922afa53c9debf86655,
title = "Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis",
abstract = "In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17, KLF4, and MYC, and embryonal carcinoma (EC) has four upregulated genes, OCT4/POU5F1, SOX2, LIN28, and NANOG. The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation of the driver genes are important for TGCT and for oncology in general.",
keywords = "differentiation, epigenetics, LIN28, NANOG, POU5F1, SOX2, testis cancer",
author = "{von Eyben}, {Finn E.} and Karsten Kristiansen and Kapp, {Daniel S.} and Rong Hu and Ovidiu Preda and Nogales, {Francisco F.}",
note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
doi = "10.3390/ijms24044148",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis

AU - von Eyben, Finn E.

AU - Kristiansen, Karsten

AU - Kapp, Daniel S.

AU - Hu, Rong

AU - Preda, Ovidiu

AU - Nogales, Francisco F.

N1 - Publisher Copyright: © 2023 by the authors.

PY - 2023

Y1 - 2023

N2 - In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17, KLF4, and MYC, and embryonal carcinoma (EC) has four upregulated genes, OCT4/POU5F1, SOX2, LIN28, and NANOG. The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation of the driver genes are important for TGCT and for oncology in general.

AB - In testicular germ cell tumor type II (TGCT), a seminoma subtype expresses an induced pluripotent stem cell (iPSC) panel with four upregulated genes, OCT4/POU5F1, SOX17, KLF4, and MYC, and embryonal carcinoma (EC) has four upregulated genes, OCT4/POU5F1, SOX2, LIN28, and NANOG. The EC panel can reprogram cells into iPSC, and both iPSC and EC can differentiate into teratoma. This review summarizes the literature on epigenetic regulation of the genes. Epigenetic mechanisms, such as methylations of cytosines on the DNA string and methylations and acetylations of histone 3 lysines, regulate expression of these driver genes between the TGCT subtypes. In TGCT, the driver genes contribute to well-known clinical characteristics and the driver genes are also important for aggressive subtypes of many other malignancies. In conclusion, epigenetic regulation of the driver genes are important for TGCT and for oncology in general.

KW - differentiation

KW - epigenetics

KW - LIN28

KW - NANOG

KW - POU5F1

KW - SOX2

KW - testis cancer

U2 - 10.3390/ijms24044148

DO - 10.3390/ijms24044148

M3 - Review

C2 - 36835562

AN - SCOPUS:85149050886

VL - 24

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 4

M1 - 4148

ER -

ID: 338528997