Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa

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Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa. / Sangula, Abraham K; Belsham, Graham; Muwanika, Vincent B; Heller, Rasmus; Balinda, Sheila N; Masembe, Charles; Siegismund, Hans Redlef.

In: BMC Evolutionary Biology, Vol. 10, No. 1, 30.11.2010, p. 371.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sangula, AK, Belsham, G, Muwanika, VB, Heller, R, Balinda, SN, Masembe, C & Siegismund, HR 2010, 'Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa', BMC Evolutionary Biology, vol. 10, no. 1, pp. 371. https://doi.org/10.1186/1471-2148-10-371

APA

Sangula, A. K., Belsham, G., Muwanika, V. B., Heller, R., Balinda, S. N., Masembe, C., & Siegismund, H. R. (2010). Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa. BMC Evolutionary Biology, 10(1), 371. https://doi.org/10.1186/1471-2148-10-371

Vancouver

Sangula AK, Belsham G, Muwanika VB, Heller R, Balinda SN, Masembe C et al. Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa. BMC Evolutionary Biology. 2010 Nov 30;10(1):371. https://doi.org/10.1186/1471-2148-10-371

Author

Sangula, Abraham K ; Belsham, Graham ; Muwanika, Vincent B ; Heller, Rasmus ; Balinda, Sheila N ; Masembe, Charles ; Siegismund, Hans Redlef. / Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa. In: BMC Evolutionary Biology. 2010 ; Vol. 10, No. 1. pp. 371.

Bibtex

@article{2897b76f07f646ea837e4e5300596f8d,
title = "Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa",
abstract = "ABSTRACT: BACKGROUND: In East Africa, foot-and-mouth disease virus serotype SAT 1 is responsible for occasional severe outbreaks in livestock and is known to be maintained within the buffalo populations. Little is known about the evolutionary forces underlying its epidemiology in the region. To enhance our appreciation of the epidemiological status of serotype SAT 1 virus in the region, we inferred its evolutionary and phylogeographic history by means of genealogy-based coalescent methods using 53 VP1 coding sequences covering a sampling period from 1948-2007. RESULTS: The VP1 coding sequence of 11 serotype SAT 1 FMD viruses from East Africa has been determined and compared with known sequences derived from other SAT 1 viruses from sub-Saharan Africa. Purifying (negative) selection and low substitution rates characterized the SAT 1 virus isolates in East Africa. Two virus groups with probable independent introductions from southern Africa were identified from a maximum clade credibility tree. One group was exclusive to Uganda while the other was present within Kenya and Tanzania. CONCLUSIONS: Our results provide a baseline characterization of the inter-regional spread of SAT 1 in sub-Saharan Africa and highlight the importance of a regional approach to trans-boundary animal disease control in order to monitor circulating strains and apply appropriate vaccines.",
author = "Sangula, {Abraham K} and Graham Belsham and Muwanika, {Vincent B} and Rasmus Heller and Balinda, {Sheila N} and Charles Masembe and Siegismund, {Hans Redlef}",
year = "2010",
month = nov,
day = "30",
doi = "10.1186/1471-2148-10-371",
language = "English",
volume = "10",
pages = "371",
journal = "B M C Evolutionary Biology",
issn = "1471-2148",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Evolutionary analysis of foot-and-mouth disease virus serotype SAT 1 isolates from East Africa suggests two independent introductions from southern Africa

AU - Sangula, Abraham K

AU - Belsham, Graham

AU - Muwanika, Vincent B

AU - Heller, Rasmus

AU - Balinda, Sheila N

AU - Masembe, Charles

AU - Siegismund, Hans Redlef

PY - 2010/11/30

Y1 - 2010/11/30

N2 - ABSTRACT: BACKGROUND: In East Africa, foot-and-mouth disease virus serotype SAT 1 is responsible for occasional severe outbreaks in livestock and is known to be maintained within the buffalo populations. Little is known about the evolutionary forces underlying its epidemiology in the region. To enhance our appreciation of the epidemiological status of serotype SAT 1 virus in the region, we inferred its evolutionary and phylogeographic history by means of genealogy-based coalescent methods using 53 VP1 coding sequences covering a sampling period from 1948-2007. RESULTS: The VP1 coding sequence of 11 serotype SAT 1 FMD viruses from East Africa has been determined and compared with known sequences derived from other SAT 1 viruses from sub-Saharan Africa. Purifying (negative) selection and low substitution rates characterized the SAT 1 virus isolates in East Africa. Two virus groups with probable independent introductions from southern Africa were identified from a maximum clade credibility tree. One group was exclusive to Uganda while the other was present within Kenya and Tanzania. CONCLUSIONS: Our results provide a baseline characterization of the inter-regional spread of SAT 1 in sub-Saharan Africa and highlight the importance of a regional approach to trans-boundary animal disease control in order to monitor circulating strains and apply appropriate vaccines.

AB - ABSTRACT: BACKGROUND: In East Africa, foot-and-mouth disease virus serotype SAT 1 is responsible for occasional severe outbreaks in livestock and is known to be maintained within the buffalo populations. Little is known about the evolutionary forces underlying its epidemiology in the region. To enhance our appreciation of the epidemiological status of serotype SAT 1 virus in the region, we inferred its evolutionary and phylogeographic history by means of genealogy-based coalescent methods using 53 VP1 coding sequences covering a sampling period from 1948-2007. RESULTS: The VP1 coding sequence of 11 serotype SAT 1 FMD viruses from East Africa has been determined and compared with known sequences derived from other SAT 1 viruses from sub-Saharan Africa. Purifying (negative) selection and low substitution rates characterized the SAT 1 virus isolates in East Africa. Two virus groups with probable independent introductions from southern Africa were identified from a maximum clade credibility tree. One group was exclusive to Uganda while the other was present within Kenya and Tanzania. CONCLUSIONS: Our results provide a baseline characterization of the inter-regional spread of SAT 1 in sub-Saharan Africa and highlight the importance of a regional approach to trans-boundary animal disease control in order to monitor circulating strains and apply appropriate vaccines.

U2 - 10.1186/1471-2148-10-371

DO - 10.1186/1471-2148-10-371

M3 - Journal article

C2 - 21118525

VL - 10

SP - 371

JO - B M C Evolutionary Biology

JF - B M C Evolutionary Biology

SN - 1471-2148

IS - 1

ER -

ID: 32148679