Standard
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. / Guo, Guangwu; Gui, Yaoting; Gao, Shengjie; Tang, Aifa; Hu, Xueda; Huang, Yi; Jia, Wenlong; Li, Zesong; He, Minghui; Sun, Liang; Song, Pengfei; Sun, Xiaojuan; Zhao, Xiaokun; Yang, Sangming; Liang, Chaozhao; Wan, Shengqing; Zhou, Fangjian; Chen, Chao; Zhu, Jialou; Li, Xianxin; Jian, Minghan; Zhou, Liang; Ye, Rui; Huang, Peide; Chen, Jing; Jiang, Tao; Liu, Xiao; Wang, Yong; Zou, Jing; Jiang, Zhimao; Wu, Renhua; Wu, Song; Fan, Fan; Zhang, Zhongfu; Liu, Lin; Yang, Ruilin; Liu, Xingwang; Wu, Haibo; Yin, Weihua; Zhao, Xia; Liu, Yuchen; Peng, Huanhuan; Jiang, Binghua; Feng, Qingxin; Li, Cailing; Xie, Jun; Lu, Jingxiao; Kristiansen, Karsten; Li, Yingrui; Zhang, Xiuqing; Li, Songgang; Wang, Jian; Yang, Huanming; Cai, Zhiming; Wang, Jun.
In:
Nature Genetics, Vol. 44, No. 1, 2012, p. 17-19.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Guo, G, Gui, Y, Gao, S, Tang, A, Hu, X, Huang, Y, Jia, W, Li, Z, He, M, Sun, L, Song, P, Sun, X, Zhao, X, Yang, S, Liang, C, Wan, S, Zhou, F, Chen, C, Zhu, J, Li, X, Jian, M, Zhou, L, Ye, R, Huang, P, Chen, J, Jiang, T, Liu, X, Wang, Y, Zou, J, Jiang, Z, Wu, R, Wu, S, Fan, F, Zhang, Z, Liu, L, Yang, R, Liu, X, Wu, H, Yin, W, Zhao, X, Liu, Y, Peng, H, Jiang, B, Feng, Q, Li, C, Xie, J, Lu, J
, Kristiansen, K, Li, Y, Zhang, X, Li, S, Wang, J, Yang, H, Cai, Z & Wang, J 2012, '
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma',
Nature Genetics, vol. 44, no. 1, pp. 17-19.
https://doi.org/10.1038/ng.1014APA
Guo, G., Gui, Y., Gao, S., Tang, A., Hu, X., Huang, Y., Jia, W., Li, Z., He, M., Sun, L., Song, P., Sun, X., Zhao, X., Yang, S., Liang, C., Wan, S., Zhou, F., Chen, C., Zhu, J., ... Wang, J. (2012).
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
Nature Genetics,
44(1), 17-19.
https://doi.org/10.1038/ng.1014Vancouver
Guo G, Gui Y, Gao S, Tang A, Hu X, Huang Y et al.
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
Nature Genetics. 2012;44(1):17-19.
https://doi.org/10.1038/ng.1014Author
Guo, Guangwu ; Gui, Yaoting ; Gao, Shengjie ; Tang, Aifa ; Hu, Xueda ; Huang, Yi ; Jia, Wenlong ; Li, Zesong ; He, Minghui ; Sun, Liang ; Song, Pengfei ; Sun, Xiaojuan ; Zhao, Xiaokun ; Yang, Sangming ; Liang, Chaozhao ; Wan, Shengqing ; Zhou, Fangjian ; Chen, Chao ; Zhu, Jialou ; Li, Xianxin ; Jian, Minghan ; Zhou, Liang ; Ye, Rui ; Huang, Peide ; Chen, Jing ; Jiang, Tao ; Liu, Xiao ; Wang, Yong ; Zou, Jing ; Jiang, Zhimao ; Wu, Renhua ; Wu, Song ; Fan, Fan ; Zhang, Zhongfu ; Liu, Lin ; Yang, Ruilin ; Liu, Xingwang ; Wu, Haibo ; Yin, Weihua ; Zhao, Xia ; Liu, Yuchen ; Peng, Huanhuan ; Jiang, Binghua ; Feng, Qingxin ; Li, Cailing ; Xie, Jun ; Lu, Jingxiao ; Kristiansen, Karsten ; Li, Yingrui ; Zhang, Xiuqing ; Li, Songgang ; Wang, Jian ; Yang, Huanming ; Cai, Zhiming ; Wang, Jun. / Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. In: Nature Genetics. 2012 ; Vol. 44, No. 1. pp. 17-19.
Bibtex
@article{0a61355031de4e5c8ce58361e66b68e2,
title = "Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma",
abstract = "We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1 alpha and HIF2 alpha in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.",
keywords = "SOMATIC MUTATIONS, CANCER, Genetics & Heredity",
author = "Guangwu Guo and Yaoting Gui and Shengjie Gao and Aifa Tang and Xueda Hu and Yi Huang and Wenlong Jia and Zesong Li and Minghui He and Liang Sun and Pengfei Song and Xiaojuan Sun and Xiaokun Zhao and Sangming Yang and Chaozhao Liang and Shengqing Wan and Fangjian Zhou and Chao Chen and Jialou Zhu and Xianxin Li and Minghan Jian and Liang Zhou and Rui Ye and Peide Huang and Jing Chen and Tao Jiang and Xiao Liu and Yong Wang and Jing Zou and Zhimao Jiang and Renhua Wu and Song Wu and Fan Fan and Zhongfu Zhang and Lin Liu and Ruilin Yang and Xingwang Liu and Haibo Wu and Weihua Yin and Xia Zhao and Yuchen Liu and Huanhuan Peng and Binghua Jiang and Qingxin Feng and Cailing Li and Jun Xie and Jingxiao Lu and Karsten Kristiansen and Yingrui Li and Xiuqing Zhang and Songgang Li and Jian Wang and Huanming Yang and Zhiming Cai and Jun Wang",
year = "2012",
doi = "10.1038/ng.1014",
language = "English",
volume = "44",
pages = "17--19",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
AU - Guo, Guangwu
AU - Gui, Yaoting
AU - Gao, Shengjie
AU - Tang, Aifa
AU - Hu, Xueda
AU - Huang, Yi
AU - Jia, Wenlong
AU - Li, Zesong
AU - He, Minghui
AU - Sun, Liang
AU - Song, Pengfei
AU - Sun, Xiaojuan
AU - Zhao, Xiaokun
AU - Yang, Sangming
AU - Liang, Chaozhao
AU - Wan, Shengqing
AU - Zhou, Fangjian
AU - Chen, Chao
AU - Zhu, Jialou
AU - Li, Xianxin
AU - Jian, Minghan
AU - Zhou, Liang
AU - Ye, Rui
AU - Huang, Peide
AU - Chen, Jing
AU - Jiang, Tao
AU - Liu, Xiao
AU - Wang, Yong
AU - Zou, Jing
AU - Jiang, Zhimao
AU - Wu, Renhua
AU - Wu, Song
AU - Fan, Fan
AU - Zhang, Zhongfu
AU - Liu, Lin
AU - Yang, Ruilin
AU - Liu, Xingwang
AU - Wu, Haibo
AU - Yin, Weihua
AU - Zhao, Xia
AU - Liu, Yuchen
AU - Peng, Huanhuan
AU - Jiang, Binghua
AU - Feng, Qingxin
AU - Li, Cailing
AU - Xie, Jun
AU - Lu, Jingxiao
AU - Kristiansen, Karsten
AU - Li, Yingrui
AU - Zhang, Xiuqing
AU - Li, Songgang
AU - Wang, Jian
AU - Yang, Huanming
AU - Cai, Zhiming
AU - Wang, Jun
PY - 2012
Y1 - 2012
N2 - We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1 alpha and HIF2 alpha in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.
AB - We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1 alpha and HIF2 alpha in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.
KW - SOMATIC MUTATIONS
KW - CANCER
KW - Genetics & Heredity
U2 - 10.1038/ng.1014
DO - 10.1038/ng.1014
M3 - Journal article
C2 - 22138691
VL - 44
SP - 17
EP - 19
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 1
ER -
