Genome organization and expression of the rat ACBP gene family
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Genome organization and expression of the rat ACBP gene family. / Mandrup, S; Andreasen, P H; Knudsen, J; Kristiansen, K.
In: Molecular and Cellular Biochemistry, Vol. 123, No. 1-2, 1993, p. 55-61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genome organization and expression of the rat ACBP gene family
AU - Mandrup, S
AU - Andreasen, P H
AU - Knudsen, J
AU - Kristiansen, K
N1 - Keywords: Acyl Coenzyme A; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA; Diazepam Binding Inhibitor; Gene Expression; Genome; Molecular Sequence Data; Multigene Family; Promoter Regions, Genetic; Pseudogenes; Rats; Rats, Sprague-Dawley; Sequence Alignment
PY - 1993
Y1 - 1993
N2 - Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.
AB - Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.
U2 - 10.1007/BF01076475
DO - 10.1007/BF01076475
M3 - Journal article
C2 - 8232269
VL - 123
SP - 55
EP - 61
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
SN - 0300-8177
IS - 1-2
ER -
ID: 11231213