Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
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Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. / Liu, Ruixin; Hong, Jie; Xu, Xiaoqiang; Feng, Qiang; Zhang, Dongya; Gu, Yanyun; Shi, Juan; Zhao, Shaoqian; Liu, Wen; Wang, Xiaokai; Xia, Huihua; Liu, Zhipeng; Cui, Bin; Liang, Peiwen; Xi, Liuqing; Jin, Jiabin; Ying, Xiayang; Wang, Xiaolin; Zhao, Xinjie; Li, Wanyu; Jia, Huijue; Lan, Zhou; Li, Fengyu; Wang, Rui; Sun, Yingkai; Yang, Minglan; Shen, Yuxin; Jie, Zhuye; Li, Junhua; Chen, Xiaomin; Zhong, Huanzi; Xie, Hailiang; Zhang, Yifei; Gu, Weiqiong; Deng, Xiaxing; Shen, Baiyong; Xu, Xun; Yang, Huanming; Xu, Guowang; Bi, Yufang; Lai, Shenghan; Wang, Jian; Qi, Lu; Madsen, Lise; Wang, Jiqiu; Ning, Guang; Kristiansen, Karsten; Wang, Weiqing.
In: Nature Medicine, Vol. 23, No. 7, 07.2017, p. 859-868.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
AU - Liu, Ruixin
AU - Hong, Jie
AU - Xu, Xiaoqiang
AU - Feng, Qiang
AU - Zhang, Dongya
AU - Gu, Yanyun
AU - Shi, Juan
AU - Zhao, Shaoqian
AU - Liu, Wen
AU - Wang, Xiaokai
AU - Xia, Huihua
AU - Liu, Zhipeng
AU - Cui, Bin
AU - Liang, Peiwen
AU - Xi, Liuqing
AU - Jin, Jiabin
AU - Ying, Xiayang
AU - Wang, Xiaolin
AU - Zhao, Xinjie
AU - Li, Wanyu
AU - Jia, Huijue
AU - Lan, Zhou
AU - Li, Fengyu
AU - Wang, Rui
AU - Sun, Yingkai
AU - Yang, Minglan
AU - Shen, Yuxin
AU - Jie, Zhuye
AU - Li, Junhua
AU - Chen, Xiaomin
AU - Zhong, Huanzi
AU - Xie, Hailiang
AU - Zhang, Yifei
AU - Gu, Weiqiong
AU - Deng, Xiaxing
AU - Shen, Baiyong
AU - Xu, Xun
AU - Yang, Huanming
AU - Xu, Guowang
AU - Bi, Yufang
AU - Lai, Shenghan
AU - Wang, Jian
AU - Qi, Lu
AU - Madsen, Lise
AU - Wang, Jiqiu
AU - Ning, Guang
AU - Kristiansen, Karsten
AU - Wang, Weiqing
PY - 2017/7
Y1 - 2017/7
N2 - Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
AB - Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
UR - http://www.scopus.com/inward/record.url?scp=85023608430&partnerID=8YFLogxK
U2 - 10.1038/nm.4358
DO - 10.1038/nm.4358
M3 - Journal article
C2 - 28628112
AN - SCOPUS:85023608430
VL - 23
SP - 859
EP - 868
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 7
ER -
ID: 181412701