Ion channels and transporters in the development of drug resistance in cancer cells
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Ion channels and transporters in the development of drug resistance in cancer cells. / Hoffmann, Else Kay; Lambert, Ian Henry.
In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 369, No. 1638, 2014.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ion channels and transporters in the development of drug resistance in cancer cells
AU - Hoffmann, Else Kay
AU - Lambert, Ian Henry
N1 - Theme Issue "Ion channels, transporters and cancer"
PY - 2014
Y1 - 2014
N2 - Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis.
AB - Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis.
UR - http://www.scopus.com/inward/record.url?scp=84893464588&partnerID=8YFLogxK
U2 - 10.1098/rstb.2013.0109
DO - 10.1098/rstb.2013.0109
M3 - Journal article
C2 - 24493757
AN - SCOPUS:84893464588
VL - 369
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0962-8436
IS - 1638
ER -
ID: 103647778