Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. / Giordano, Antonio; Perugini, Jessica; Kristensen, David Møbjerg; Sartini, Loris; Frontini, Andrea; Kajimura, Shingo; Kristiansen, Karsten; Cinti, Saverio.

In: Journal of Cellular Physiology, Vol. 232, No. 11, 2017, p. 2923-2928.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Giordano, A, Perugini, J, Kristensen, DM, Sartini, L, Frontini, A, Kajimura, S, Kristiansen, K & Cinti, S 2017, 'Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice', Journal of Cellular Physiology, vol. 232, no. 11, pp. 2923-2928. https://doi.org/10.1002/jcp.25858

APA

Giordano, A., Perugini, J., Kristensen, D. M., Sartini, L., Frontini, A., Kajimura, S., Kristiansen, K., & Cinti, S. (2017). Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. Journal of Cellular Physiology, 232(11), 2923-2928. https://doi.org/10.1002/jcp.25858

Vancouver

Giordano A, Perugini J, Kristensen DM, Sartini L, Frontini A, Kajimura S et al. Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. Journal of Cellular Physiology. 2017;232(11):2923-2928. https://doi.org/10.1002/jcp.25858

Author

Giordano, Antonio ; Perugini, Jessica ; Kristensen, David Møbjerg ; Sartini, Loris ; Frontini, Andrea ; Kajimura, Shingo ; Kristiansen, Karsten ; Cinti, Saverio. / Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. In: Journal of Cellular Physiology. 2017 ; Vol. 232, No. 11. pp. 2923-2928.

Bibtex

@article{305fd6cf1c8d45809796aa36eea97b73,
title = "Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice",
abstract = "During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary glandtransdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate bytransmission electron microscopy that in the post-lactating mammary gland interscapularmultilocular adipocytes found close to the mammary alveoli contain milk protein granules. Useof the Cre-loxP recombination system allowed showing that the involuting mammary gland ofwhey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene duringpregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapularmultilocular adipocytes. These data suggest that during mammary gland involution some milk-secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brownadipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity",
keywords = "adipose organ, Cre-loxP recombination system, electron microscopy, mammary gland, pregnancy",
author = "Antonio Giordano and Jessica Perugini and Kristensen, {David M{\o}bjerg} and Loris Sartini and Andrea Frontini and Shingo Kajimura and Karsten Kristiansen and Saverio Cinti",
year = "2017",
doi = "10.1002/jcp.25858",
language = "English",
volume = "232",
pages = "2923--2928",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "JohnWiley & Sons, Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice

AU - Giordano, Antonio

AU - Perugini, Jessica

AU - Kristensen, David Møbjerg

AU - Sartini, Loris

AU - Frontini, Andrea

AU - Kajimura, Shingo

AU - Kristiansen, Karsten

AU - Cinti, Saverio

PY - 2017

Y1 - 2017

N2 - During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary glandtransdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate bytransmission electron microscopy that in the post-lactating mammary gland interscapularmultilocular adipocytes found close to the mammary alveoli contain milk protein granules. Useof the Cre-loxP recombination system allowed showing that the involuting mammary gland ofwhey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene duringpregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapularmultilocular adipocytes. These data suggest that during mammary gland involution some milk-secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brownadipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity

AB - During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary glandtransdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate bytransmission electron microscopy that in the post-lactating mammary gland interscapularmultilocular adipocytes found close to the mammary alveoli contain milk protein granules. Useof the Cre-loxP recombination system allowed showing that the involuting mammary gland ofwhey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene duringpregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapularmultilocular adipocytes. These data suggest that during mammary gland involution some milk-secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brownadipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity

KW - adipose organ

KW - Cre-loxP recombination system

KW - electron microscopy

KW - mammary gland

KW - pregnancy

U2 - 10.1002/jcp.25858

DO - 10.1002/jcp.25858

M3 - Journal article

C2 - 28191637

VL - 232

SP - 2923

EP - 2928

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

IS - 11

ER -

ID: 183637824