Molecular basis of potassium channels in pancreatic duct epithelial cells

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Molecular basis of potassium channels in pancreatic duct epithelial cells. / Hayashi, M.; Novak, Ivana.

In: Channels (Austin), Vol. 7, No. 6, 2013, p. 432-441.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hayashi, M & Novak, I 2013, 'Molecular basis of potassium channels in pancreatic duct epithelial cells', Channels (Austin), vol. 7, no. 6, pp. 432-441. https://doi.org/10.4161/chan.26100

APA

Hayashi, M., & Novak, I. (2013). Molecular basis of potassium channels in pancreatic duct epithelial cells. Channels (Austin), 7(6), 432-441. https://doi.org/10.4161/chan.26100

Vancouver

Hayashi M, Novak I. Molecular basis of potassium channels in pancreatic duct epithelial cells. Channels (Austin). 2013;7(6):432-441. https://doi.org/10.4161/chan.26100

Author

Hayashi, M. ; Novak, Ivana. / Molecular basis of potassium channels in pancreatic duct epithelial cells. In: Channels (Austin). 2013 ; Vol. 7, No. 6. pp. 432-441.

Bibtex

@article{eeb91ebaeada4f73af1610e071b72cc9,
title = "Molecular basis of potassium channels in pancreatic duct epithelial cells",
abstract = "Potassium channels regulate excitability, epithelial ion transport, proliferation, and apoptosis. In pancreatic ducts, K channels hyperpolarize the membrane potential and provide the driving force for anion secretion. This review focuses on the molecular candidates of functional K channels in pancreatic duct cells, including KCNN4 (K 3.1), KCNMA1 (K1.1), KCNQ1 (K7.1), KCNH2 (K11.1), KCNH5 (K10.2), KCNT1 (K4.1), KCNT2 (K4.2), and KCNK5 (K5.1). We will give an overview of K channels with respect to their electrophysiological and pharmacological characteristics and regulation, which we know from other cell types, preferably in epithelia, and, where known, their identification and functions in pancreatic ducts and in adenocarcinoma cells. We conclude by pointing out some outstanding questions and future directions in pancreatic K channel research with respect to the physiology of secretion and pancreatic pathologies, including pancreatitis, cystic fibrosis, and cancer, in which the dysregulation or altered expression of K channels may be of importance.",
author = "M. Hayashi and Ivana Novak",
year = "2013",
doi = "10.4161/chan.26100",
language = "English",
volume = "7",
pages = "432--441",
journal = "Channels",
issn = "1933-6950",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Molecular basis of potassium channels in pancreatic duct epithelial cells

AU - Hayashi, M.

AU - Novak, Ivana

PY - 2013

Y1 - 2013

N2 - Potassium channels regulate excitability, epithelial ion transport, proliferation, and apoptosis. In pancreatic ducts, K channels hyperpolarize the membrane potential and provide the driving force for anion secretion. This review focuses on the molecular candidates of functional K channels in pancreatic duct cells, including KCNN4 (K 3.1), KCNMA1 (K1.1), KCNQ1 (K7.1), KCNH2 (K11.1), KCNH5 (K10.2), KCNT1 (K4.1), KCNT2 (K4.2), and KCNK5 (K5.1). We will give an overview of K channels with respect to their electrophysiological and pharmacological characteristics and regulation, which we know from other cell types, preferably in epithelia, and, where known, their identification and functions in pancreatic ducts and in adenocarcinoma cells. We conclude by pointing out some outstanding questions and future directions in pancreatic K channel research with respect to the physiology of secretion and pancreatic pathologies, including pancreatitis, cystic fibrosis, and cancer, in which the dysregulation or altered expression of K channels may be of importance.

AB - Potassium channels regulate excitability, epithelial ion transport, proliferation, and apoptosis. In pancreatic ducts, K channels hyperpolarize the membrane potential and provide the driving force for anion secretion. This review focuses on the molecular candidates of functional K channels in pancreatic duct cells, including KCNN4 (K 3.1), KCNMA1 (K1.1), KCNQ1 (K7.1), KCNH2 (K11.1), KCNH5 (K10.2), KCNT1 (K4.1), KCNT2 (K4.2), and KCNK5 (K5.1). We will give an overview of K channels with respect to their electrophysiological and pharmacological characteristics and regulation, which we know from other cell types, preferably in epithelia, and, where known, their identification and functions in pancreatic ducts and in adenocarcinoma cells. We conclude by pointing out some outstanding questions and future directions in pancreatic K channel research with respect to the physiology of secretion and pancreatic pathologies, including pancreatitis, cystic fibrosis, and cancer, in which the dysregulation or altered expression of K channels may be of importance.

UR - http://www.scopus.com/inward/record.url?scp=84891679456&partnerID=8YFLogxK

U2 - 10.4161/chan.26100

DO - 10.4161/chan.26100

M3 - Journal article

C2 - 23962792

AN - SCOPUS:84891679456

VL - 7

SP - 432

EP - 441

JO - Channels

JF - Channels

SN - 1933-6950

IS - 6

ER -

ID: 99353466