Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression. / Li, Zhiming; Lai, Jianbo; Zhang, Peifen; Ding, Jiahong; Jiang, Jiajun; Liu, Chuanfa; Huang, Huimin; Zhen, Hefu; Xi, Caixi; Sun, Yuzhe; Wu, Lingling; Wang, Lifang; Gao, Xingle; Li, Yan; Fu, Yaoyang; Jie, Zhuye; Li, Shenghui; Zhang, Danhua; Chen, Yiqing; Zhu, Yiyi; Lu, Shaojia; Lu, Jing; Wang, Dandan; Zhou, Hetong; Yuan, Xiuxia; Li, Xue; Pang, Lijuan; Huang, Manli; Yang, Huanming; Zhang, Wenwei; Brix, Susanne; Kristiansen, Karsten; Song, Xueqin; Nie, Chao; Hu, Shaohua.
In: Molecular Psychiatry, Vol. 27, No. 1, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression
AU - Li, Zhiming
AU - Lai, Jianbo
AU - Zhang, Peifen
AU - Ding, Jiahong
AU - Jiang, Jiajun
AU - Liu, Chuanfa
AU - Huang, Huimin
AU - Zhen, Hefu
AU - Xi, Caixi
AU - Sun, Yuzhe
AU - Wu, Lingling
AU - Wang, Lifang
AU - Gao, Xingle
AU - Li, Yan
AU - Fu, Yaoyang
AU - Jie, Zhuye
AU - Li, Shenghui
AU - Zhang, Danhua
AU - Chen, Yiqing
AU - Zhu, Yiyi
AU - Lu, Shaojia
AU - Lu, Jing
AU - Wang, Dandan
AU - Zhou, Hetong
AU - Yuan, Xiuxia
AU - Li, Xue
AU - Pang, Lijuan
AU - Huang, Manli
AU - Yang, Huanming
AU - Zhang, Wenwei
AU - Brix, Susanne
AU - Kristiansen, Karsten
AU - Song, Xueqin
AU - Nie, Chao
AU - Hu, Shaohua
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022
Y1 - 2022
N2 - The intricate processes of microbiota-gut-brain communication in modulating human cognition and emotion, especially in the context of mood disorders, have remained elusive. Here we performed faecal metagenomic, serum metabolomics and neuroimaging studies on a cohort of 109 unmedicated patients with depressed bipolar disorder (BD) patients and 40 healthy controls (HCs) to characterise the microbial-gut-brain axis in BD. Across over 12,000 measured metabolic features, we observed a large discrepancy (73.54%) in the serum metabolome between BD patients and HCs, spotting differentially abundant microbial-derived neuroactive metabolites including multiple B-vitamins, kynurenic acid, gamma-aminobutyric acid and short-chain fatty acids. These metabolites could be linked to the abundance of gut microbiota presented with corresponding biosynthetic potentials, including Akkermansia muciniphila, Citrobacter spp. (Citrobacter freundii and Citrobacter werkmanii), Phascolarctobacterium spp., Yersinia spp. (Yersinia frederiksenii and Yersinia aleksiciae), Enterobacter spp. (Enterobacter cloacae and Enterobacter kobei) and Flavobacterium spp. Based on functional neuroimaging, BD-related neuroactive microbes and metabolites were discovered as potential markers associated with BD-typical features of functional connectivity of brain networks, hinting at aberrant cognitive function, emotion regulation, and interoception. Our study combines gut microbiota and neuroactive metabolites with brain functional connectivity, thereby revealing potential signalling pathways from the microbiota to the gut and the brain, which may have a role in the pathophysiology of BD.
AB - The intricate processes of microbiota-gut-brain communication in modulating human cognition and emotion, especially in the context of mood disorders, have remained elusive. Here we performed faecal metagenomic, serum metabolomics and neuroimaging studies on a cohort of 109 unmedicated patients with depressed bipolar disorder (BD) patients and 40 healthy controls (HCs) to characterise the microbial-gut-brain axis in BD. Across over 12,000 measured metabolic features, we observed a large discrepancy (73.54%) in the serum metabolome between BD patients and HCs, spotting differentially abundant microbial-derived neuroactive metabolites including multiple B-vitamins, kynurenic acid, gamma-aminobutyric acid and short-chain fatty acids. These metabolites could be linked to the abundance of gut microbiota presented with corresponding biosynthetic potentials, including Akkermansia muciniphila, Citrobacter spp. (Citrobacter freundii and Citrobacter werkmanii), Phascolarctobacterium spp., Yersinia spp. (Yersinia frederiksenii and Yersinia aleksiciae), Enterobacter spp. (Enterobacter cloacae and Enterobacter kobei) and Flavobacterium spp. Based on functional neuroimaging, BD-related neuroactive microbes and metabolites were discovered as potential markers associated with BD-typical features of functional connectivity of brain networks, hinting at aberrant cognitive function, emotion regulation, and interoception. Our study combines gut microbiota and neuroactive metabolites with brain functional connectivity, thereby revealing potential signalling pathways from the microbiota to the gut and the brain, which may have a role in the pathophysiology of BD.
U2 - 10.1038/s41380-022-01569-9
DO - 10.1038/s41380-022-01569-9
M3 - Journal article
C2 - 35444255
AN - SCOPUS:85128463830
VL - 27
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
IS - 1
ER -
ID: 308896767