Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle

Research output: Contribution to journalJournal articlepeer-review

Standard

Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. / Holst, Dorte; Luquet, Serge; Nogueira, Véronique; Kristiansen, Karsten; Leverve, Xavier; Grimaldi, Paul A.

In: BBA General Subjects, Vol. 1633, No. 1, 04.07.2003, p. 43-50.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Holst, D, Luquet, S, Nogueira, V, Kristiansen, K, Leverve, X & Grimaldi, PA 2003, 'Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle', BBA General Subjects, vol. 1633, no. 1, pp. 43-50.

APA

Holst, D., Luquet, S., Nogueira, V., Kristiansen, K., Leverve, X., & Grimaldi, P. A. (2003). Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. BBA General Subjects, 1633(1), 43-50.

Vancouver

Holst D, Luquet S, Nogueira V, Kristiansen K, Leverve X, Grimaldi PA. Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. BBA General Subjects. 2003 Jul 4;1633(1):43-50.

Author

Holst, Dorte ; Luquet, Serge ; Nogueira, Véronique ; Kristiansen, Karsten ; Leverve, Xavier ; Grimaldi, Paul A. / Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. In: BBA General Subjects. 2003 ; Vol. 1633, No. 1. pp. 43-50.

Bibtex

@article{b3e7b039c84141acb5228b756e3c1fc1,
title = "Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle",
abstract = "Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors primarily involved in lipid homeostasis. PPARdelta displays strong expression in tissues with high lipid metabolism, such as adipose, intestine and muscle. Its role in skeletal muscle remains largely unknown. After a 24-h starvation period, PPARdelta mRNA levels are dramatically up-regulated in gastrocnemius muscle of mice and restored to control level upon refeeding. The rise of PPARdelta is accompanied by parallel up-regulations of fatty acid translocase/CD36 (FAT/CD36) and heart fatty acid binding protein (H-FABP), while refeeding promotes down-regulation of both genes. To directly access the role of PPARdelta in muscle cells, we forced its expression and that of a dominant-negative PPARdelta mutant in C2C12 myogenic cells. Differentiated C2C12 cells responds to 2-bromopalmitate or synthetic PPARdelta agonist by induction of genes involved in lipid metabolism and increment of fatty acid oxidation. Overexpression of PPARdelta enhanced these cellular responses, whereas expression of the dominant-negative mutant exerts opposite effects. These data strongly support a role for PPARdelta in the regulation of fatty acid oxidation in skeletal muscle and in adaptive response of this tissue to lipid catabolism.",
keywords = "Animals, Carbon Radioisotopes, Cell Differentiation, Cell Line, Fatty Acids, Gene Expression Regulation, Kinetics, Male, Mice, Mice, Inbred C57BL, Muscle, Skeletal, Mutation, Nutritional Physiological Phenomena, Palmitates, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Transcriptional Activation",
author = "Dorte Holst and Serge Luquet and V{\'e}ronique Nogueira and Karsten Kristiansen and Xavier Leverve and Grimaldi, {Paul A}",
year = "2003",
month = jul,
day = "4",
language = "English",
volume = "1633",
pages = "43--50",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle

AU - Holst, Dorte

AU - Luquet, Serge

AU - Nogueira, Véronique

AU - Kristiansen, Karsten

AU - Leverve, Xavier

AU - Grimaldi, Paul A

PY - 2003/7/4

Y1 - 2003/7/4

N2 - Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors primarily involved in lipid homeostasis. PPARdelta displays strong expression in tissues with high lipid metabolism, such as adipose, intestine and muscle. Its role in skeletal muscle remains largely unknown. After a 24-h starvation period, PPARdelta mRNA levels are dramatically up-regulated in gastrocnemius muscle of mice and restored to control level upon refeeding. The rise of PPARdelta is accompanied by parallel up-regulations of fatty acid translocase/CD36 (FAT/CD36) and heart fatty acid binding protein (H-FABP), while refeeding promotes down-regulation of both genes. To directly access the role of PPARdelta in muscle cells, we forced its expression and that of a dominant-negative PPARdelta mutant in C2C12 myogenic cells. Differentiated C2C12 cells responds to 2-bromopalmitate or synthetic PPARdelta agonist by induction of genes involved in lipid metabolism and increment of fatty acid oxidation. Overexpression of PPARdelta enhanced these cellular responses, whereas expression of the dominant-negative mutant exerts opposite effects. These data strongly support a role for PPARdelta in the regulation of fatty acid oxidation in skeletal muscle and in adaptive response of this tissue to lipid catabolism.

AB - Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors primarily involved in lipid homeostasis. PPARdelta displays strong expression in tissues with high lipid metabolism, such as adipose, intestine and muscle. Its role in skeletal muscle remains largely unknown. After a 24-h starvation period, PPARdelta mRNA levels are dramatically up-regulated in gastrocnemius muscle of mice and restored to control level upon refeeding. The rise of PPARdelta is accompanied by parallel up-regulations of fatty acid translocase/CD36 (FAT/CD36) and heart fatty acid binding protein (H-FABP), while refeeding promotes down-regulation of both genes. To directly access the role of PPARdelta in muscle cells, we forced its expression and that of a dominant-negative PPARdelta mutant in C2C12 myogenic cells. Differentiated C2C12 cells responds to 2-bromopalmitate or synthetic PPARdelta agonist by induction of genes involved in lipid metabolism and increment of fatty acid oxidation. Overexpression of PPARdelta enhanced these cellular responses, whereas expression of the dominant-negative mutant exerts opposite effects. These data strongly support a role for PPARdelta in the regulation of fatty acid oxidation in skeletal muscle and in adaptive response of this tissue to lipid catabolism.

KW - Animals

KW - Carbon Radioisotopes

KW - Cell Differentiation

KW - Cell Line

KW - Fatty Acids

KW - Gene Expression Regulation

KW - Kinetics

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Muscle, Skeletal

KW - Mutation

KW - Nutritional Physiological Phenomena

KW - Palmitates

KW - RNA, Messenger

KW - Receptors, Cytoplasmic and Nuclear

KW - Transcription Factors

KW - Transcriptional Activation

M3 - Journal article

C2 - 12842194

VL - 1633

SP - 43

EP - 50

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 1

ER -

ID: 35457582