PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

Research output: Contribution to journalJournal articlepeer-review

Standard

PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. / Petersen, Rasmus Koefoed; Larsen, Signe Liv Benzon; Jensen, Ditte Marie; Christensen, Jane; Olsen, Anja; Loft, Steffen; Nellemann, Christine Lydia; Overvad, Kim; Kristiansen, Karsten; Tjønneland, Anne; Vogel, Ulla.

In: Cancer Letters, Vol. 315, No. 1, 2012, p. 59-68.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Petersen, RK, Larsen, SLB, Jensen, DM, Christensen, J, Olsen, A, Loft, S, Nellemann, CL, Overvad, K, Kristiansen, K, Tjønneland, A & Vogel, U 2012, 'PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer', Cancer Letters, vol. 315, no. 1, pp. 59-68. https://doi.org/10.1016/j.canlet.2011.10.009

APA

Petersen, R. K., Larsen, S. L. B., Jensen, D. M., Christensen, J., Olsen, A., Loft, S., Nellemann, C. L., Overvad, K., Kristiansen, K., Tjønneland, A., & Vogel, U. (2012). PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Letters, 315(1), 59-68. https://doi.org/10.1016/j.canlet.2011.10.009

Vancouver

Petersen RK, Larsen SLB, Jensen DM, Christensen J, Olsen A, Loft S et al. PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. Cancer Letters. 2012;315(1):59-68. https://doi.org/10.1016/j.canlet.2011.10.009

Author

Petersen, Rasmus Koefoed ; Larsen, Signe Liv Benzon ; Jensen, Ditte Marie ; Christensen, Jane ; Olsen, Anja ; Loft, Steffen ; Nellemann, Christine Lydia ; Overvad, Kim ; Kristiansen, Karsten ; Tjønneland, Anne ; Vogel, Ulla. / PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. In: Cancer Letters. 2012 ; Vol. 315, No. 1. pp. 59-68.

Bibtex

@article{a3579a1fa4934dedb3c0fe2bc61d774e,
title = "PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer",
abstract = "Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR¿ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR¿ and the PPAR¿-PGC-1a complex was inhibited by ethanol. PPAR¿ 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR¿ 12Pro-PGC-1a complex. Our results suggest that PPAR¿ and PGC-1a activity is an important determinant of alcohol related breast cancer.",
author = "Petersen, {Rasmus Koefoed} and Larsen, {Signe Liv Benzon} and Jensen, {Ditte Marie} and Jane Christensen and Anja Olsen and Steffen Loft and Nellemann, {Christine Lydia} and Kim Overvad and Karsten Kristiansen and Anne Tj{\o}nneland and Ulla Vogel",
note = "Copyright {\textcopyright} 2011 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
doi = "10.1016/j.canlet.2011.10.009",
language = "English",
volume = "315",
pages = "59--68",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

AU - Petersen, Rasmus Koefoed

AU - Larsen, Signe Liv Benzon

AU - Jensen, Ditte Marie

AU - Christensen, Jane

AU - Olsen, Anja

AU - Loft, Steffen

AU - Nellemann, Christine Lydia

AU - Overvad, Kim

AU - Kristiansen, Karsten

AU - Tjønneland, Anne

AU - Vogel, Ulla

N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR¿ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR¿ and the PPAR¿-PGC-1a complex was inhibited by ethanol. PPAR¿ 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR¿ 12Pro-PGC-1a complex. Our results suggest that PPAR¿ and PGC-1a activity is an important determinant of alcohol related breast cancer.

AB - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR¿ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR¿ and the PPAR¿-PGC-1a complex was inhibited by ethanol. PPAR¿ 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR¿ 12Pro-PGC-1a complex. Our results suggest that PPAR¿ and PGC-1a activity is an important determinant of alcohol related breast cancer.

U2 - 10.1016/j.canlet.2011.10.009

DO - 10.1016/j.canlet.2011.10.009

M3 - Journal article

C2 - 22050908

VL - 315

SP - 59

EP - 68

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -

ID: 35396657