PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
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PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer. / Petersen, Rasmus Koefoed; Larsen, Signe Liv Benzon; Jensen, Ditte Marie; Christensen, Jane; Olsen, Anja; Loft, Steffen; Nellemann, Christine Lydia; Overvad, Kim; Kristiansen, Karsten; Tjønneland, Anne; Vogel, Ulla.
In: Cancer Letters, Vol. 315, No. 1, 2012, p. 59-68.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
AU - Petersen, Rasmus Koefoed
AU - Larsen, Signe Liv Benzon
AU - Jensen, Ditte Marie
AU - Christensen, Jane
AU - Olsen, Anja
AU - Loft, Steffen
AU - Nellemann, Christine Lydia
AU - Overvad, Kim
AU - Kristiansen, Karsten
AU - Tjønneland, Anne
AU - Vogel, Ulla
N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR¿ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR¿ and the PPAR¿-PGC-1a complex was inhibited by ethanol. PPAR¿ 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR¿ 12Pro-PGC-1a complex. Our results suggest that PPAR¿ and PGC-1a activity is an important determinant of alcohol related breast cancer.
AB - Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR¿ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR¿ and the PPAR¿-PGC-1a complex was inhibited by ethanol. PPAR¿ 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR¿ 12Pro-PGC-1a complex. Our results suggest that PPAR¿ and PGC-1a activity is an important determinant of alcohol related breast cancer.
U2 - 10.1016/j.canlet.2011.10.009
DO - 10.1016/j.canlet.2011.10.009
M3 - Journal article
C2 - 22050908
VL - 315
SP - 59
EP - 68
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -
ID: 35396657