Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down

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Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down. / Dreisig, H; Andreasen, P H; Kristiansen, K.

In: European Journal of Biochemistry, Vol. 140, No. 3, 1984, p. 469-75.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Dreisig, H, Andreasen, PH & Kristiansen, K 1984, 'Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down', European Journal of Biochemistry, vol. 140, no. 3, pp. 469-75. https://doi.org/10.1111/j.1432-1033.1984.tb08126.x

APA

Dreisig, H., Andreasen, P. H., & Kristiansen, K. (1984). Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down. European Journal of Biochemistry, 140(3), 469-75. https://doi.org/10.1111/j.1432-1033.1984.tb08126.x

Vancouver

Dreisig H, Andreasen PH, Kristiansen K. Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down. European Journal of Biochemistry. 1984;140(3):469-75. https://doi.org/10.1111/j.1432-1033.1984.tb08126.x

Author

Dreisig, H ; Andreasen, P H ; Kristiansen, K. / Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down. In: European Journal of Biochemistry. 1984 ; Vol. 140, No. 3. pp. 469-75.

Bibtex

@article{e0127b5013cb11de8478000ea68e967b,
title = "Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down",
abstract = "When exponentially growing cells of Tetrahymena pyriformis are transferred to a non-nutrient medium the loss of whole cell RNA, 90% of which is ribosomal RNA, exhibits biphasic kinetics, whereas whole cell protein is lost at a constant rate. The ratio RNA/protein declines during the first 5 h of starvation and then remains constant during the subsequent period of starvation. The synthesis of the majority of the ribosomal proteins is coordinately regulated during a nutritional shift-down. Exponentially growing cells devote 17% of their capacity for protein synthesis to the production of ribosomal proteins. Upon starvation this proportion is rapidly reduced 3.5-fold. In long-time-starved cells the absolute rate of ribosomal protein synthesis is only about 4.5% of that of exponentially growing cells. The synthesis of ribosomal RNA and ribosomal proteins appears tightly coupled during the transition from growth to starvation. In long-time-starved cells the synthesis of ribosomal RNA and ribosomal proteins are stoichiometrically balanced with no significant degradation of de novo synthesized ribosomal proteins.",
author = "H Dreisig and Andreasen, {P H} and K Kristiansen",
note = "Keywords: Animals; Culture Media; Electrophoresis, Polyacrylamide Gel; Kinetics; Polyribosomes; RNA, Ribosomal; Ribosomal Proteins; Ribosomes; Tetrahymena pyriformis",
year = "1984",
doi = "10.1111/j.1432-1033.1984.tb08126.x",
language = "English",
volume = "140",
pages = "469--75",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Springer Verlag",
number = "3",

}

RIS

TY - JOUR

T1 - Regulation of ribosome synthesis in Tetrahymena pyriformis. 1. Coordination of synthesis of ribosomal proteins and ribosomal RNA during nutritional shift-down

AU - Dreisig, H

AU - Andreasen, P H

AU - Kristiansen, K

N1 - Keywords: Animals; Culture Media; Electrophoresis, Polyacrylamide Gel; Kinetics; Polyribosomes; RNA, Ribosomal; Ribosomal Proteins; Ribosomes; Tetrahymena pyriformis

PY - 1984

Y1 - 1984

N2 - When exponentially growing cells of Tetrahymena pyriformis are transferred to a non-nutrient medium the loss of whole cell RNA, 90% of which is ribosomal RNA, exhibits biphasic kinetics, whereas whole cell protein is lost at a constant rate. The ratio RNA/protein declines during the first 5 h of starvation and then remains constant during the subsequent period of starvation. The synthesis of the majority of the ribosomal proteins is coordinately regulated during a nutritional shift-down. Exponentially growing cells devote 17% of their capacity for protein synthesis to the production of ribosomal proteins. Upon starvation this proportion is rapidly reduced 3.5-fold. In long-time-starved cells the absolute rate of ribosomal protein synthesis is only about 4.5% of that of exponentially growing cells. The synthesis of ribosomal RNA and ribosomal proteins appears tightly coupled during the transition from growth to starvation. In long-time-starved cells the synthesis of ribosomal RNA and ribosomal proteins are stoichiometrically balanced with no significant degradation of de novo synthesized ribosomal proteins.

AB - When exponentially growing cells of Tetrahymena pyriformis are transferred to a non-nutrient medium the loss of whole cell RNA, 90% of which is ribosomal RNA, exhibits biphasic kinetics, whereas whole cell protein is lost at a constant rate. The ratio RNA/protein declines during the first 5 h of starvation and then remains constant during the subsequent period of starvation. The synthesis of the majority of the ribosomal proteins is coordinately regulated during a nutritional shift-down. Exponentially growing cells devote 17% of their capacity for protein synthesis to the production of ribosomal proteins. Upon starvation this proportion is rapidly reduced 3.5-fold. In long-time-starved cells the absolute rate of ribosomal protein synthesis is only about 4.5% of that of exponentially growing cells. The synthesis of ribosomal RNA and ribosomal proteins appears tightly coupled during the transition from growth to starvation. In long-time-starved cells the synthesis of ribosomal RNA and ribosomal proteins are stoichiometrically balanced with no significant degradation of de novo synthesized ribosomal proteins.

U2 - 10.1111/j.1432-1033.1984.tb08126.x

DO - 10.1111/j.1432-1033.1984.tb08126.x

M3 - Journal article

C2 - 6426953

VL - 140

SP - 469

EP - 475

JO - FEBS Journal

JF - FEBS Journal

SN - 1742-464X

IS - 3

ER -

ID: 11368503