Ribosome synthesis in Tetrahymena: a quantitative analysis

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Ribosome synthesis in Tetrahymena: a quantitative analysis. / Larsen, L K; Andreasen, P H; Kristiansen, K.

In: Cell Biology International, Vol. 23, No. 11, 1999, p. 729-38.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Larsen, LK, Andreasen, PH & Kristiansen, K 1999, 'Ribosome synthesis in Tetrahymena: a quantitative analysis', Cell Biology International, vol. 23, no. 11, pp. 729-38. https://doi.org/10.1006/cbir.1999.0376

APA

Larsen, L. K., Andreasen, P. H., & Kristiansen, K. (1999). Ribosome synthesis in Tetrahymena: a quantitative analysis. Cell Biology International, 23(11), 729-38. https://doi.org/10.1006/cbir.1999.0376

Vancouver

Larsen LK, Andreasen PH, Kristiansen K. Ribosome synthesis in Tetrahymena: a quantitative analysis. Cell Biology International. 1999;23(11):729-38. https://doi.org/10.1006/cbir.1999.0376

Author

Larsen, L K ; Andreasen, P H ; Kristiansen, K. / Ribosome synthesis in Tetrahymena: a quantitative analysis. In: Cell Biology International. 1999 ; Vol. 23, No. 11. pp. 729-38.

Bibtex

@article{bbe361d00fb211de8478000ea68e967b,
title = "Ribosome synthesis in Tetrahymena: a quantitative analysis",
abstract = "We have performed a detailed quantitative analysis of the transcription and accumulation of ribosomal RNA and ribosomal protein mRNA in the ciliated protozoan Tetrahymena thermophila during changes in growth conditions, and found that: (1) nutritional downshifts lead to a rapid decrease in transcriptional activity whereas nutritional upshifts lead to rapid restoration of transcriptional activity, (2) starvation leads to decreased translation of ribosomal protein mRNA and (3) the rate of ribosomal protein mRNA degradation decreases after a nutritional upshift. We present evidence that the proximal promoters of two ribosomal protein genes and the ribosomal RNA gene compete for binding of nuclear factor(s) in vitro, suggesting that the coordinated regulation of these genes may involve a common set of transcriptional regulators.",
author = "Larsen, {L K} and Andreasen, {P H} and K Kristiansen",
note = "Keywords: Animals; Cell Nucleus; Kinetics; RNA, Messenger; RNA, Ribosomal; Ribosomal Proteins; Ribosomes; Tetrahymena thermophila; Transcription, Genetic",
year = "1999",
doi = "10.1006/cbir.1999.0376",
language = "English",
volume = "23",
pages = "729--38",
journal = "Cell Biology International",
issn = "1065-6995",
publisher = "Academic Press",
number = "11",

}

RIS

TY - JOUR

T1 - Ribosome synthesis in Tetrahymena: a quantitative analysis

AU - Larsen, L K

AU - Andreasen, P H

AU - Kristiansen, K

N1 - Keywords: Animals; Cell Nucleus; Kinetics; RNA, Messenger; RNA, Ribosomal; Ribosomal Proteins; Ribosomes; Tetrahymena thermophila; Transcription, Genetic

PY - 1999

Y1 - 1999

N2 - We have performed a detailed quantitative analysis of the transcription and accumulation of ribosomal RNA and ribosomal protein mRNA in the ciliated protozoan Tetrahymena thermophila during changes in growth conditions, and found that: (1) nutritional downshifts lead to a rapid decrease in transcriptional activity whereas nutritional upshifts lead to rapid restoration of transcriptional activity, (2) starvation leads to decreased translation of ribosomal protein mRNA and (3) the rate of ribosomal protein mRNA degradation decreases after a nutritional upshift. We present evidence that the proximal promoters of two ribosomal protein genes and the ribosomal RNA gene compete for binding of nuclear factor(s) in vitro, suggesting that the coordinated regulation of these genes may involve a common set of transcriptional regulators.

AB - We have performed a detailed quantitative analysis of the transcription and accumulation of ribosomal RNA and ribosomal protein mRNA in the ciliated protozoan Tetrahymena thermophila during changes in growth conditions, and found that: (1) nutritional downshifts lead to a rapid decrease in transcriptional activity whereas nutritional upshifts lead to rapid restoration of transcriptional activity, (2) starvation leads to decreased translation of ribosomal protein mRNA and (3) the rate of ribosomal protein mRNA degradation decreases after a nutritional upshift. We present evidence that the proximal promoters of two ribosomal protein genes and the ribosomal RNA gene compete for binding of nuclear factor(s) in vitro, suggesting that the coordinated regulation of these genes may involve a common set of transcriptional regulators.

U2 - 10.1006/cbir.1999.0376

DO - 10.1006/cbir.1999.0376

M3 - Journal article

C2 - 10736197

VL - 23

SP - 729

EP - 738

JO - Cell Biology International

JF - Cell Biology International

SN - 1065-6995

IS - 11

ER -

ID: 11254307